| 1. |
- Tuskan, G A, et al.
(författare)
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The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 313:5793, s. 1596-604
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Tidskriftsartikel (refereegranskat)abstract
- We report the draft genome of the black cottonwood tree, Populus trichocarpa. Integration of shotgun sequence assembly with genetic mapping enabled chromosome-scale reconstruction of the genome. More than 45,000 putative protein-coding genes were identified. Analysis of the assembled genome revealed a whole-genome duplication event; about 8000 pairs of duplicated genes from that event survived in the Populus genome. A second, older duplication event is indistinguishably coincident with the divergence of the Populus and Arabidopsis lineages. Nucleotide substitution, tandem gene duplication, and gross chromosomal rearrangement appear to proceed substantially more slowly in Populus than in Arabidopsis. Populus has more protein-coding genes than Arabidopsis, ranging on average from 1.4 to 1.6 putative Populus homologs for each Arabidopsis gene. However, the relative frequency of protein domains in the two genomes is similar. Overrepresented exceptions in Populus include genes associated with lignocellulosic wall biosynthesis, meristem development, disease resistance, and metabolite transport.
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| 2. |
- Hellsten, Torbjörn, et al.
(författare)
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Fast wave current drive in JET ITB-plasma
- 2005
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Ingår i: AIP Conference Proceedings. - : AIP. - 0094-243X. ; , s. 273-278
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Konferensbidrag (refereegranskat)abstract
- Fast wave current drive has been performed in JET plasmas with internal transport barriers, ITBs, and strongly reversed magnetic shear. Although the current drive efficiency of the power absorbed on the electrons is fairly high, only small effects are seen in the central current density. The main reasons are the parasitic absorption of RF power, the strongly inductive nature of the plasma and the interplay between the fast wave driven current and bootstrap current. The direct electron heating in the FWCD experiments is found to be strongly degraded compared to that with the dipole phasing.
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| 3. |
- Mantsinen, M. J., et al.
(författare)
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Fast ion distributions driven by polychromatic ICRF waves on JET
- 2005
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 47:9, s. 1439-1457
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Tidskriftsartikel (refereegranskat)abstract
- Experiments have been carried out on the JET tokamak to investigate fast He-3 and hydrogen minority ion populations accelerated by ion cyclotron range of frequencies (ICRF) waves launched with multiple frequencies (i.e. up to four frequencies separated by up to approximate to 15%). This 'polychromatic' heating is compared with single-frequency, 'monochromatic', ICRF heating of reference discharges with similar power levels. Information on the fast ion populations is provided by two-dimensional gamma-ray emission tomography and the measurements are compared with numerical modelling. Polychromatic heating with resonances in the plasma centre (R-res approximate to R-0) and on the low magnetic-field side (LFS) (R-res > R-0) is found to produce predominantly high-energy standard trapped ions, while resonances on the high magnetic-field side (R-res < R-0) increase the fraction of high-energy passing ions. Monochromatic heating with a central resonance produces stronger gamma-ray emission with the maximum emission in the midplane close to, and on the LFS of, the resonance, in agreement with the calculated radial distribution of fast ion orbits. Both the fast ion tail temperature and energy content are found to be lower with polychromatic waves. Polychromatic ICRF heating has the advantage of producing smaller-amplitude and shorter-period sawteeth, consistent with a lower fast ion pressure inside the q = 1 surface, and higher ion to electron temperature ratios.
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| 4. |
- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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| 5. |
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| 6. |
- Lamalle, P. U., et al.
(författare)
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Expanding the operating space of ICRF on JET with a view to ITER
- 2006
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 46:2, s. 391-400
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports on ITER-relevant ion cyclotron resonance frequency (ICRF) physics investigated on JET in 2003 and early 2004. Minority heating of helium three in hydrogen plasmas-(He-3)H-was systematically explored by varying the 3 He concentration and the toroidal phasing of the antenna arrays. The best heating performance (a maximum electron temperature of 6.2 keV with 5 MW of ICRF power) was obtained with a preferential wave launch in the direction of the plasma current. A clear experimental demonstration was made of the sharp and reproducible transition to the mode conversion heating regime when the 3 He concentration increased above similar to 2%. In the latter regime the best heating performance (a maximum electron temperature of 8 keV with 5 MW of ICRF power) was achieved with dipole array phasing, i.e. a symmetric antenna power spectrum. Minority heating of deuterium in hydrogen plasmas-(D)H-was also investigated but was found inaccessible because this scenario is too sensitive to impurity ions with Z/A = 1/2 such as C6+, small amounts of which directly lead into the mode conversion regime. Minority heating of up to 3% of tritium in deuterium plasmas was systematically investigated during the JET trace tritium experimental campaign (TTE). This required operating JET at its highest possible magnetic field (3.9 to 4 T) and the ICRF system at its lowest frequency (23 MHz). The interest of this scenario for ICRF heating at these low concentrations and its efficiency at boosting the suprathermal neutron yield were confirmed, and the measured neutron and gammay ray spectra permit interesting comparisons with advanced ICRF code simulations. Investigations of finite Larmor radius effects on the RF-induced high-energy tails during second harmonic (omega = 2 omega(c)) heating of a hydrogen minority in D plasmas clearly demonstrated a strong decrease in the RF diffusion coefficient at proton energies similar to 1 MeV in agreement with theoretical expectations. Fast wave heating and current drive experiments in deuterium plasmas showed effective direct electron heating with dipole phasing of the antennas, but only small changes of the central plasma current density were observed with the directive phasings, in particular at low single pass damping. New investigations of the heating efficiency of ICRF antennas confirmed its strong dependence on the parallel wavenumber spectrum. Advances in topics of a more technological nature are also summarized: ELM studies using fast RF measurements, the successful experimental demonstration of a new ELM-tolerant antenna matching scheme and technical enhancements planned on the JET ICRF system for 2006, they being equally strongly driven by the preparation for ITER.
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| 7. |
- Mantsinen, M. J., et al.
(författare)
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Modification of sawtooth oscillations with ICRF waves in the JET tokamak
- 2007
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Ingår i: RADIO FREQUENCY POWER IN PLASMAS. - : AIP. - 9780735404441 ; , s. 35-42
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Konferensbidrag (refereegranskat)abstract
- Methods of modifying sawtooth oscillations using waves in the ion cyclotron range of frequencies (ICRF) in the JET tokamak are presented. Examples of sawtooth stabilization by ICRF-accelerated high-energy ions are shown, including experiments with ICRF-acceleration of 4He-beam ions to simulate the effects of fusion born alpha particles. With high power ICRF heating in low-density plasmas, fast ion stabilization of sawteeth is lost and a new type of small-period and small-amplitude sawteeth appears. ICRF-induced radial pinch with toroidally asymmetric waves is found to be useful in affecting the radial profile of the ICRF-driven fast ion populations and thereby their influence on sawteeth. Ion cyclotron current drive (ICCD) applied close to the sawtooth inversion radius is effective in modifying the sawtooth period. The latest achievements include the successful application of ICCD to shorten the fast-ion-induced long-period sawteeth and thereby avoid triggering of neoclassical tearing modes (NTMs).
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| 8. |
- Bishop, Kevin, et al.
(författare)
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The Effects of Forestry on Hg Bioaccumulation in Nemoral/Boreal Waters and Recommendations for Good Silvicultural Practice
- 2009
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Ingår i: Ambio. - : Royal Swedish Academy of Sciences. - 0044-7447 .- 1654-7209. ; 38:7, s. 373-380
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Tidskriftsartikel (refereegranskat)abstract
- Mercury (Hg) levels are alarmingly high in fish from lakes across Fennoscandia and northern North America. The few published studies on the ways in which silviculture practices influence this problem indicate that forest operations increase Hg in downstream aquatic ecosystems. From these studies, we estimate that between one-tenth and one-quarter of the Hg in the fish of high-latitude, managed forest landscapes can be attributed to harvesting. Forestry, however, did not create the elevated Hg levels in the soils, and waterborne Hg/MeHg concentrations downstream from harvested areas are similar to those from wetlands. Given the current understanding of the way in which silviculture impacts Hg cycling, most of the recommendations for good forest practice in Sweden appear to be appropriate for high-latitude regions, e.g., leaving riparian buffer zones, as well as reducing disturbance at stream crossings and in moist areas. The recommendation to restore wetlands and reduce drainage, however, will likely increase Hg/MeHg loadings to aquatic ecosystems
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| 9. |
- Ongena, J., et al.
(författare)
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Overview of recent results on Heating and Current Drive in JET
- 2007
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Ingår i: RADIO FREQUENCY POWER IN PLASMAS. - : AIP. ; , s. 249-256
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Konferensbidrag (refereegranskat)abstract
- Recent progress on heating and current drive on JET is reported. Topics discussed are: high power coupling of ICRF/LH at ITER relevant antenna/launcher-separatrix distances, succesfull demonstration of 3 dB couplers for ELM tolerance of the ICRF system, influence of ICRF on LH operation, rotation studies in plasma without external momentum with standard and enhanced JET toriodal field ripple, studies of different ICRF heating schemes and of NTM avoidance schemes using Ion Cyclotron Current Drive. A brief outlook on future plans for experiments at JET is given.
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| 10. |
- Simpson, David, 1961, et al.
(författare)
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Comparison of modelled and monitored deposition fluxes of sulphur and nitrogen to ICP-forest sites in Europe
- 2006
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Ingår i: Biogeosciences. - 1726-4170 .- 1726-4189. ; 3:3, s. 337-355
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Tidskriftsartikel (refereegranskat)abstract
- The EMEP MSC-W Eulerian chemical transport model, and its predictions of deposition of acidifying and eutrophying pollutants over Europe, play a key role in the development of emission control strategies for Europe. It is important that this model is tested against observational data. Here we compare the results of the EMEP model with measured data from 160 sites of the European Union/ICP Forest (Level II) monitoring network, for the years 1997 and 2000. This comparison comprises: (a) Precipitation amount, (b) Total deposition of SO42- to coniferous and deciduous forests, (c) Wet deposition of SO42-, NO3- and NH4+ in open field sites, and (d) Concentrations of SO42-, NO3- and NH4+ in precipitation. Concerning precipitation, the EMEP model and ICP network showed very similar overall levels (within 4% for 1997 and 11% for 2000). The correlation was, however, poor (r2=0.15-0.23). This can be attributed largely to the influence of a few outliers, combined with a small range of rainfall amounts for most points. Correlations between modelled and observed deposition values in this study were rather high (r2 values between 0.4-0.8 for most components and years), with mean values across all sites being within 30%. The EMEP model tends to give somewhat lower values for SO42-, NO3- and NH4+ wet deposition to ICP, but differences in mean values were within 20% in 1997 and 30% in 2000. Modelled and observed concentrations of SO 42-, NO3- and NH4+ in precipitation are very similar on average (differences of 0-14%), with good correlation between modelled and observed data (r 2=0.50-0.78). Differences between the EMEP model and ICP measurements are thought to arise from a mixture of problems with both the observations and model. However, the overall conclusion is that the EMEP model performs rather well in reproducing patterns of S and N deposition to European forests.
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