| 1. |
|
|
| 2. |
|
|
| 3. |
- Abdellah, Tebani, et al.
(författare)
-
Integration of molecular profiles in a longitudinal wellness profiling cohort.
- 2020
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies andimmune cell profiling, complementedwith gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
|
|
| 4. |
- Andrén, Kerstin, 1980, et al.
(författare)
-
Survival in treated idiopathic normal pressure hydrocephalus
- 2020
-
Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 267, s. 640-648
-
Tidskriftsartikel (refereegranskat)abstract
- Objective To describe survival and causes of death in 979 treated iNPH patients from the Swedish Hydrocephalus Quality Registry (SHQR), and to examine the influence of comorbidities, symptom severity and postoperative outcome. Methods All 979 patients operated for iNPH 2004-2011 and registered in the SHQR were included. A matched control group of 4890 persons from the general population was selected by Statistics Sweden. Data from the Swedish Cause of Death Registry was obtained for patients and controls. Results At a median 5.9 (IQR 4.2-8.1) year follow-up, 37% of the iNPH patients and 23% of the controls had died. Mortality was increased in iNPH patients by a hazard ratio of 1.81, 95% CI 1.61-2.04, p < 0.001. More pronounced symptoms in the preoperative ordinal gait scale and the Mini-mental State Examination were the most important independent predictors of mortality along with the prevalence of heart disease. Patients who improved in both the gait scale and in the modified Rankin Scale postoperatively (n = 144) had a similar survival as the general population (p = 0.391). Deaths due to cerebrovascular disease or dementia were more common in iNPH patients, while more controls died because of neoplasms or disorders of the circulatory system. Conclusions Mortality in operated iNPH patients is 1.8 times increased compared to the general population, a lower figure than previously reported. The survival of iNPH patients who improve in gait and functional independence is similar to that of the general population, indicating that shunt surgery for iNPH, besides improving symptoms and signs, can normalize survival.
|
|
| 5. |
- Bergman, Torbjörn, 1957-, et al.
(författare)
-
Appendix : On definition and measurement
- 2021
-
Ingår i: Coalition governance in Western Europe. - Oxford : Oxford University Press. - 9780198868484 ; , s. 727-748
-
Bokkapitel (refereegranskat)abstract
- The appendix introduces our empirical study of the coalition life cycle. The structure of each country chapter is based on six core tables, each one capturing a major stage in the coalition life cycle. In the book chapters, the tables help structure the analysis and provide wealth of information and details of the coalition cycle. Nevertheless, the book chapters and this appendix only present a sample of the data and information that we have collected for this research project. For reasons of space, we have had to limit the presentation in the book chapters in terms of time-periods and variables. This appendix presents many more details that are important for readers who are not familiar with the definitions used in coalition research or interested in how particular variables where measured. In addition to the definitions and measurements presented in this appendix, all the data and all the variables are presented in an on-line data appendix at www.erdda.org.
|
|
| 6. |
- Bergman, Torbjörn, 1957-, et al.
(författare)
-
Coalition governance in Western Europe
- 2021
-
Ingår i: Coalition governance in Western Europe. - Oxford : Oxford University Press. - 9780198868484 ; , s. 1-14
-
Bokkapitel (refereegranskat)abstract
- This chapter describes the ambitions with the volume. First, we build on the lessons from earlier studies of governments in Western and Central Eastern Europe to deepen our understanding of the coalition life cycle, covering the three stages of a government's "life", beginning with the formation process, then turning to the governance stage, and lastly turning to the final phase when governments eventually terminate. Second, we seek to capture how recent changes in the Western European party systems, which are also described here, influence the various stages of the coalition life cycle. Third, we are in particular interested in how coalition partners cooperate and make policy once a government has formed, aiming to contribute to the growing literature on the topic of coalition governance. The chapter ends with a description of the content of the volume.
|
|
| 7. |
- Bergman, Torbjörn, 1957-, et al.
(författare)
-
Coalition governance patterns across Western Europe
- 2021
-
Ingår i: Coalition governance in Western Europe. - Oxford : Oxford University Press. - 9780198868484 ; , s. 680-726
-
Bokkapitel (refereegranskat)abstract
- We here summarize and compares the empirical results found by our country authors, focusing on the coalition life cycle in 17 countries. The chapter starts with a description of the changes that have occurred during the past decades in the party systems of Western Europe, and some institutional rules surrounding government formation and duration. We then turn to the comparing patterns of government formation across countries, showing that coalitions constitute almost 70 percent of the cabinets in Western Europe, and that the Scandinavian countries have been dominated by minority cabinets. Focusing on the coalition governance stage, we analyse the variation in the use of various control mechanisms across countries, for example showing that many coalition governments draft extensive contracts to control their partners in cabinet. The comparative data we present also shows that such agreements have become longer over time. Focusing on the last stage of the life cycle, we show that in a majority of countries, it is more common that a cabinet terminates early than serves the full term. There has also been a clear trend towards more government instability, even though the variation in cabinet duration across countries is large. We conclude this chapter by returning to the three coalition governance models described earlier in this volume, classifying the countries as being closer to one of the three models, based on a number of indicators and the information provided by our country experts.
|
|
| 8. |
- Bergman, Torbjörn, 1957-, et al.
(författare)
-
The three stages of the coalition life cycle
- 2021
-
Ingår i: Coalition governance in Western Europe. - Oxford : Oxford University Press. - 9780198868484 ; , s. 15-40
-
Bokkapitel (refereegranskat)abstract
- This chapter focuses on presenting the main research questions and answers provided in the literature on the different stages of the coalition life cycle. For example, focusing on the first stage, the formation stage, several researchers have tried to explain why specific types of governments form. Other scholars have asked why it take longer to form governments in some contexts. Other scholars have tried to explain how parties distribute ministerial and policy payoffs when forming a cabinet. Focusing on the second stage of the coalition life cycle, we review the growing literature on coalition governance, concentrating on three coalition governance models; the ministerial autonomy model, the coalition compromise model, and the PM dominated model – three models which make different assumptions about the actors that dominate the governance process in coalition governments. Focusing on the last phase of the coalition life cycle, the termination of governments, scholars have long aimed to explain the duration of cabinets, asking why some cabinets last longer than others. At the end of this chapter, we present some expectations about changes to the coalition life cycle which we are likely to observe considering the party system change we have seen in many Western European countries.
|
|
| 9. |
- Bronge, Mattias, et al.
(författare)
-
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
- 2022
-
Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 8:17
-
Tidskriftsartikel (refereegranskat)abstract
- Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharacterized. Using a novel in vitro antigen delivery method combined with the Human Protein Atlas library, we screened for T cell autoreactivity against 63 CNS-expressed proteins. We identified four previously unreported autoantigens in MS: fatty acid-binding protein 7, prokineticin-2, reticulon-3, and synaptosomal-associated protein 91, which were verified to induce interferon-gamma responses in MS in two cohorts. Autoreactive profiles were heterogeneous, and reactivity to several autoantigens was MS-selective. Autoreactive T cells were predominantly CD4(+) and human leukocyte antigen-DR restricted. Mouse immunization induced antigen-specific responses and CNS leukocyte infiltration. This represents one of the largest systematic efforts to date in the search for MS autoantigens, demonstrates the heterogeneity of autoreactive profiles, and highlights promising targets for future diagnostic tools and immunomodulatory therapies in MS.
|
|
| 10. |
|
|
