| 1. |
- Capala, J, et al.
(författare)
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Boron neutron capture therapy for glioblastoma multiforme : Clinical studies in Sweden
- 2003
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Ingår i: Journal of Neuro-Oncology. - 1573-7373. ; 62:1, s. 135-144
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Tidskriftsartikel (refereegranskat)abstract
- A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/moderator configurations. One of the resulting neutron beams has been optimized for clinical irradiations with a filter/moderator system that allows easy variation of the neutron spectrum from the thermal to the epithermal energy range. The other beam has been designed to produce a large uniform field of thermal neutrons for radio-biological research. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with academia. The clinical Phase II trials for glioblastoma are sponsored by the Swedish National Neuro-Oncology Group and, presently, involve a protocol for BNCT treatment of glioblastoma patients who have not received any therapy other than surgery. In this protocol, p-boronophenylalanine (BPA), administered as a 6-h intravenous infusion, is used as the boron delivery agent. As of January 2002, 17 patients were treated. The 6-h infusion of 900 mg BPA/kg body weight was shown to be safe and resulted in the average blood-boron concentration of 24 μg/g (range: 15-32 μg/g) at the time of irradiation (approximately 2-3 h post-infusion). Peak and average weighted radiation doses to the brain were in the ranges of 8.0-15.5 Gy(W) and 3.3-6.1 Gy(W), respectively. So far, no severe BNCT-related acute toxicities have been observed. Due to the short follow-up time, it is too early to evaluate the efficacy of these studies.
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| 2. |
- Akin, Danny E., et al.
(författare)
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Progress in enzyme-retting of flax
- 2004
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Ingår i: Journal of Natural Fibers. - 1544-0478. ; 1:1, s. 21-47
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Tidskriftsartikel (refereegranskat)abstract
- New methods for retting flax are sought to overcome problems in the current method of dew-retting of flax. Published data are reviewed and new data presented on the development and testing of a method to ret flax using pectinase-rich enzyme mixtures plus chelators based on cost and fiber yield and properties. In spray enzyme retting (SER), flax stems are crimped to physically disrupt the plant's protective barrier and then sprayed until soaked with, or briefly immersed in, an enzyme/ chelator formulation. Flax is then incubated at temperatures optimal for enzyme activity, washed, and dried. Pilot scale tests, conducted with 10 kg samples of flax retted with a series of formulations, showed that this method effectively retted flax stems from a variety of sources, including fiber flax, mature fiber flax, and linseed straw. Fiber yield, strength, and fineness were significantly influenced by variations in enzyme-chelator amounts. Cellulases in pectinase mixtures appeared to preferentially attack dislocations in fibers and fiber bundles resulting in loss of fiber strength. Polygalacturonases alone effectively separated fiber from non-fiber components. The SER method proved to be an effective framework for further tests on enzyme-chelator formulations that now must be integrated with physical processing to optimize the extraction of flax fibers based on cost and fiber yield and properties.
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| 3. |
- Asplund, R, et al.
(författare)
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Nocturia and depression
- 2004
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Ingår i: BJU international. - 1464-4096. ; 93:9, s. 1253-1256
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Tidskriftsartikel (refereegranskat)
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| 4. |
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| 5. |
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| 6. |
- Frech, Wolfgang, et al.
(författare)
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Characterization of a pressurizable two-step atomizer for atomic absorption spectrometry
- 2000
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Ingår i: Spectrochimica Acta Part B: Atomic Spectroscopy. ; 55:5, s. 461-72
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Tidskriftsartikel (refereegranskat)abstract
- A two-step atomizer consisting of a transversely heated atomization tube with integrated contacts and a cup furnace for sample vaporization was constructed. The system could accommodate tubes of various lengths and it could be operated at selected pressures. There was no physical contact between the tube and the cup and mainly diffusion was responsible for the sample vapour transport from the cup to the tube. Under these conditions there was an unavoidable loss by 40% of the peak area signals due to the gap between the cup and the tube. For a 24-mm tube, characteristic masses were on the average three times lower than for the state of the art transverse heated graphite atomizers (THGA). By de-coupling the processes of analyte vaporization and atomization the dynamic working range could be increased by three to six times using conventional measurements by atomic absorption spectrometry (AAS). In this case the cup temperature and hence the rate of analyte transport from the cup to the tube was controlled such that atom density in the tube did not exceed the linear range of the absorbance measurement. Carrying out clean-out steps at reduced pressure decreased memory effects.
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| 7. |
- Gamble, G. R., et al.
(författare)
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Phenolic constituents in flax bast tissue and inhibition of cellulase and pectinase
- 2000
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Ingår i: Biotechnology letters. - 0141-5492 .- 1573-6776. ; 22:9, s. 741-746
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Tidskriftsartikel (refereegranskat)abstract
- Flax bast tissue was sequentially extracted using hexane, propanol, methanol and water as solvents and extracts were analyzed using reverse phase HPLC and C-13 NMR. Results indicated a large variety of aromatic constituents including flavonoids and hydroxy-methoxy cinnamic acids linked to oligosaccharides and hydroxy acids through glycosidic linkages. The extracts inhibited cellulase and pectinase activities and can thus influence retting.
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| 8. |
- Gorini, Giuseppe, et al.
(författare)
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Neutron Emission from Beam-Injected Fast Tritons in JET Plasmas with Reversed or Monotonic Magnetic Shear.
- 2004
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Ingår i: 31st EPS Conference on Plasma Physics. ; , s. 4-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The neutron emission from fast tritons in plasmas with different magnetic shearconfigurations has been investigated in a dedicated experiment on JET. Short pulses ofneutral beam injection were used to deposit fast tritons in deuterium plasmas. By comparingthe measured neutron yield with predictions based on DT reaction calculations, fast tritonlosses can be assessed. The latter are expected to be very low according to neoclassicalpredictions based on Fokker-Planck simulation [1]. Much larger “anomalous” beam-ionlosses (up to 40%) have been reported in TFTR experiments for plasma conditions withreversed magnetic shear [2]. The TFTR experiments indicated an excess DT rate in thesimulation and, to a lesser extent, in the DD rate and plasma stored energy. This wasinterpreted as anomalous beam-ion loss associated with reverse shear due to an unidentifiedloss mechanism. Evidence of a similar effect was searched for in the JET experimentsreported in this paper.
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