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Bone marrow-derived...
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
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- Nygren, Jens Martin, 1976- (författare)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine,Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Jovinge, Stefan (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Breitbach, Martin (författare)
- Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Säwén, Petter (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Röll, Wilhelm (författare)
- Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Hescheler, Jürgen (författare)
- Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Taneera, Jalal (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Fleischmann, Bernd K (författare)
- Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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- Jacobsen, Sten Eirik W (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
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(creator_code:org_t)
- 2004-04-25
- 2004
- Engelska.
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 10:5, s. 494-501
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Abstract
Ämnesord
Stäng
- Recent studies have suggested that bone marrow cells might possess a much broader differentiation potential than previously appreciated. In most cases, the reported efficiency of such plasticity has been rather low and, at least in some instances, is a consequence of cell fusion. After myocardial infarction, however, bone marrow cells have been suggested to extensively regenerate cardiomyocytes through transdifferentiation. Although bone marrow-derived cells are already being used in clinical trials, the exact identity, longevity and fate of these cells in infarcted myocardium have yet to be investigated in detail. Here we use various approaches to induce acute myocardial injury and deliver transgenically marked bone marrow cells to the injured myocardium. We show that unfractionated bone marrow cells and a purified population of hematopoietic stem and progenitor cells efficiently engraft within the infarcted myocardium. Engraftment was transient, however, and hematopoietic in nature. In contrast, bone marrow-derived cardiomyocytes were observed outside the infarcted myocardium at a low frequency and were derived exclusively through cell fusion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Animals
- Cell Differentiation
- Cell Fusion
- Cell Movement
- Graft Survival
- Green Fluorescent Proteins
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Lac Operon
- Luminescent Proteins
- Mice
- Mice
- Inbred C57BL
- Mice
- Transgenic
- Myocardial Infarction
- Myocytes
- Cardiac
- Recombinant Proteins
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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