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- Brattström, Daniel, et al.
(författare)
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Serum VEGF and bFGF adds prognostic information in patients with normal platelet counts when sampled before, during and after treatment for locally advanced non-small cell lung cancer
- 2003
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Ingår i: Lung Cancer. - : Elsevier BV. - 0169-5002 .- 1872-8332. ; 43:1, s. 55-62
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Tidskriftsartikel (refereegranskat)abstract
- Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) have both been implicated to have roles in tumour angiogenesis. In the present retrospective study, serum VEGF and bFGF from patients with locally advanced non-small cell lung cancer (NSCLC) were analysed before, during and after treatment. Seventy-three patients and a total of 460 serum samples were analysed for VEGF and 443 serum samples were analysed for bFGF. Pre-treatment bFGF levels in patients with normal platelet counts, were correlated to poorer survival, P-value = 0.047. During chemotherapy, each rise of one unit bFGF corresponded to a hazard ratio of 4.06 (P=0.022). In patients with normal platelet counts, VEGF levels after radiotherapy significantly correlated to good prognosis (P=0.023), during radiotherapy VEGF levels indicated the same correlation (P=0.085). We conclude that serum VEGF and especially bFGF are of clinical interest as prognostic factors, especially in patients presenting with normal platelet counts.
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- Hesselius, Patrik
(författare)
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Does sick absence increase the risk of unemployment?
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The paper examines whether a worker's sick absence behaviour influences the risk of becoming unemployed. Swedish panel data are used to estimate the relationship between the incidence and duration of sick leave and subsequent unemployment. The results indicate that an increase in the number of sick leaves as well as an increase in the duration of sick spells is associated with higher risk of unemployment. Women have a significantly higher risk then men of unemployment associated with sick leave spells longer than 28 days. An implication of the results is that less absence-prone workers are more likely to remain employed in a recession. This in turn may in part explain the pro-cyclical pattern of aggregate Swedish sick absence rates.
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