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The growing world o...
The growing world of small heat shock proteins : from structure to functions
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- Carra, Serena (författare)
- University of Modena and Reggio Emilia
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- Alberti, Simon (författare)
- Max Planck Institute of Molecular Cell Biology and Genetics
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- Arrigo, Patrick A. (författare)
- Claude Bernard University Lyon 1
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- Benesch, Justin L. (författare)
- University of Oxford
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- Benjamin, Ivor J. (författare)
- University of Utah
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- Boelens, Wilbert C. (författare)
- Radboud University Nijmegen
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- Bartelt-Kirbach, Britta (författare)
- University of Ulm
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- Brundel, Bianca J. J. M. (författare)
- University of Groningen,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Buchner, Johannes (författare)
- Technical University of Munich
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- Bukau, Bernd (författare)
- Heidelberg University,German Cancer Research Centre
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- Carver, John A. (författare)
- Australian National University
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- Ecroyd, Heath (författare)
- University of Wollongong
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- Emanuelsson, Cecilia (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Finet, Stephanie (författare)
- Paris-Sorbonne University
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- Golenhofen, Nikola (författare)
- University of Ulm
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- Goloubinoff, Pierre (författare)
- University of Lausanne
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- Gusev, Nikolai (författare)
- Lomonosov Moscow State University
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- Haslbeck, Martin (författare)
- Technical University of Munich
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- Hightower, Lawrence E. (författare)
- University of Connecticut
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- Kampinga, Harm H. (författare)
- University of Groningen
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- Klevit, Rachel E. (författare)
- University of Washington
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- Liberek, Krzysztof (författare)
- Medical University of Gdansk
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- Mchaourab, Hassane S. (författare)
- Vanderbilt University
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- McMenimen, Kathryn A. (författare)
- University of Michigan
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- Poletti, Angelo (författare)
- University of Milan
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- Quinlan, Roy (författare)
- Durham University
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- Strelkov, Sergei V. (författare)
- Catholic University of Leuven
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- Toth, Melinda E. (författare)
- Hungarian Academy of Sciences
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- Vierling, Elizabeth (författare)
- University of Massachusetts,University of Arizona
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- Tanguay, Robert M. (författare)
- Laval University
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(creator_code:org_t)
- 2017-03-31
- 2017
- Engelska.
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Ingår i: Cell Stress and Chaperones. - : Springer Science and Business Media LLC. - 1355-8145 .- 1466-1268. ; 22:4, s. 601-611
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability, from bacteria to plants to humans. sHSPs have the ability to bind to a large subset of substrates and to maintain them in a state competent for refolding or clearance with the assistance of the HSP70 machinery. sHSPs participate in a number of biological processes, from the cell cycle, to cell differentiation, from adaptation to stressful conditions, to apoptosis, and, even, to the transformation of a cell into a malignant state. As a consequence, sHSP malfunction has been implicated in abnormal placental development and preterm deliveries, in the prognosis of several types of cancer, and in the development of neurological diseases. Moreover, mutations in the genes encoding several mammalian sHSPs result in neurological, muscular, or cardiac age-related diseases in humans. Loss of protein homeostasis due to protein aggregation is typical of many age-related neurodegenerative and neuromuscular diseases. In light of the role of sHSPs in the clearance of un/misfolded aggregation-prone substrates, pharmacological modulation of sHSP expression or function and rescue of defective sHSPs represent possible routes to alleviate or cure protein conformation diseases. Here, we report the latest news and views on sHSPs discussed by many of the world’s experts in the sHSP field during a dedicated workshop organized in Italy (Bertinoro, CEUB, October 12–15, 2016).
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Hsp27
- Neurological diseases
- Protein aggregates
- Protein conformation
- Protein homeostasis
- Small heat shock proteins
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- art (ämneskategori)
- ref (ämneskategori)
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Carra, Serena
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Alberti, Simon
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Arrigo, Patrick ...
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Benesch, Justin ...
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Benjamin, Ivor J ...
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Boelens, Wilbert ...
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visa fler...
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Bartelt-Kirbach, ...
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Brundel, Bianca ...
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Buchner, Johanne ...
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Bukau, Bernd
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Carver, John A.
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Ecroyd, Heath
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Emanuelsson, Cec ...
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Finet, Stephanie
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Golenhofen, Niko ...
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Goloubinoff, Pie ...
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Gusev, Nikolai
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Haslbeck, Martin
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Hightower, Lawre ...
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Kampinga, Harm H ...
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Klevit, Rachel E ...
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Liberek, Krzyszt ...
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Mchaourab, Hassa ...
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McMenimen, Kathr ...
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Poletti, Angelo
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Quinlan, Roy
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Strelkov, Sergei ...
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Toth, Melinda E.
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Vierling, Elizab ...
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Tanguay, Robert ...
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- NATURVETENSKAP
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och Cellbiologi
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Cell Stress and ...
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