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Deregulated Aurora-...
Deregulated Aurora-B induced tetraploidy promotes tumorigenesis
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- Nguyen, Hao G. (författare)
- Boston University School of Medicine
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Mäkitalo, Maria (författare)
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- Yang, Dan (författare)
- Boston University School of Medicine
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- Chinnappan, Dharmaraj (författare)
- Boston University School of Medicine
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- Hilaire, Cynthia St. (författare)
- Boston University School of Medicine
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- Ravid, Katya (författare)
- Boston University School of Medicine
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(creator_code:org_t)
- 2009-03-30
- 2009
- Engelska.
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Ingår i: The FASEB Journal. - : Wiley. - 0892-6638 .- 1530-6860. ; 23:8, s. 2741-2748
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- High expression of Aurora-B has been observed in various cancers, and inhibition of this kinase has been shown to halt cellular proliferation. However, the mechanism of effect of Aurora-B on cellular transformation has not been fully explored. Here, we show that overexpression of Aurora-B in murine epithelial cells promotes generation of tetraploids. In search of a related mechanism, spectral karyotyping was carried out, showing premature chromatid separation (PCS). Of interest, PCS is a hallmark of Robert's syndrome, which also involves cellular polyploidy and aneuploidy. Sorted tetraploid Aurora-B-overexpressing cells promoted significant mammary epithelial cancers when injected into nude mice, as compared to injection of nonfractionated cells, suggesting that tetraploidy is an important mediator of Aurora-B-induced tumorigenesis. Comparative chromosome hybridization performed on DNA derived from tetraploid cell-induced tumors indicates amplifications and deletions of regions throughout the genome, which include tumor-promoting or tumor-suppressing genes, respectively. Thus, sustained expression of Aurora-B induces tetraploidy, which, in turn, facilitates genomic instability and tumor development in a xenograft model
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Geokemi (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geochemistry (hsv//eng)
Nyckelord
- Applied Geology
- Tillämpad geologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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