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- Sandström, Malin, et al.
(författare)
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The impact of the distribution of isoforms on CaMKII activation
- 2006
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Ingår i: Neurocomputing. - : Elsevier BV. - 0925-2312. ; 69:10-12, s. 1010-1013
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Tidskriftsartikel (refereegranskat)abstract
- We have developed a computational model of the regulation of alpha- and beta-CaMKII activity, in order to examine (i) the importance of neighbour subunit interactions and (ii) the effect the higher CaMCa4 affinity of beta-CaMKII has on the holoenzyme activity in different configurations with the same alpha: beta ratio. The model consists of a deterministic biochemical network coupled to stochastic activation of CaMKII The results suggest that CaMKII holoenzyme activity is non-linear and dependent on the holoenzyme configuration of isoforms. This is especially pronounced in situations with a high-dephosphorylation rate of CaMKII.
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