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Search: WFRF:(Hofer S)

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1.
  • Ahmad, T., et al. (author)
  • Frequency and outcomes of undiagnosed diabetes mellitus in patients presenting with acute myocardial infarction
  • 2020
  • In: Medical Forum Monthly. - : Medical Forum Monthly. - 1029-385X. ; 31:12, s. 3-7
  • Journal article (peer-reviewed)abstract
    • Objective: To find out frequency and outcomes of undiagnosed diabetes mellitus in patients presenting with acute ST elevation myocardial infarction (STEMI). Study Design: Descriptive / Cross-Sectional Study Place and Duration of study: This study was conducted at the Cardiology Department, Lady Reading Hospital, Peshawar from November 2018 to May 2019. Materials and Methods: Patient of either gender having age ranging between 30-75 years old with acute STEMI who present within 12 hours of symptoms and with no past history of documented diabetes mellitus were included in the study. Venous blood samples for laboratory data, including random blood sugar, two fasting blood sugar and HBA1c using hitachi modular evo p800 machine was done. Results: A total of 158 patients having acute STEMI were studied. Males were 68.4% (n=108).The mean age was 59.65 ±10.80 years. Frequency of undiagnosed diabetes mellitus was 31.64 % (n = 50). In non-diabetics stress hyperglycemia was found in 51.85 % (n=56) patients. Among various types of STEMI, anterior STEMI was more common presentation 34.1 % (n=54. p= 0.85). Mean HBA1C was 6.19 ± 1.87%. Frequency of Ventricular tachycardia (VT) was 22.2 % in which undiagnosed diabetics were n=18 (p=0.004).Ventricular fibrillation was present in 13.3 % patients with undiagnosed diabetics were n=14 (p=0.001). Frequency of AF was 13.9% (n=22) with undiagnosed diabetics having AF in n=13 (p=0.003). SVT was present in 5.7% (n=9) patients with not significant difference between two groups (p=0.017). Among various mechanical complications VSR was present in 10 % (n=16) of patients (p=0.001), cardiogenic shock in 11.1 % (n=18) patients (p=0.004), acute LVF was present in 15.8 % patients (p=0.017). Conclusion: In our study we concluded that one third of patients having acute ST elevation myocardial infarction have undiagnosed diabetes mellitus (31.64 %, n = 50). The most common complication was ventricular tachycardia among electrical complication and LVF among mechanical complication.
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  • Ahmad, T, et al. (author)
  • Skeletal changes in type-2 diabetic Goto-Kakizaki rats.
  • 2003
  • In: The Journal of endocrinology. - : Bioscientifica. - 0022-0795 .- 1479-6805. ; 178:1, s. 111-6
  • Journal article (peer-reviewed)abstract
    • We characterized appendicular and axial bones in rats with type-2 diabetes in five female Goto-Kakizaki (GK) rats, a strain developed from the Wistar rat showing spontaneous type-2 diabetes, and five age- and sex-matched non-diabetic Wistar rats. The humerus, tibia, metatarsals and vertebral bodies were analysed by peripheral quantitative computerized tomography (pQCT). In diabetic rats, the height of the vertebral bodies and length of the humerus were decreased while the length of the metatarsals was increased. A decreased cross-sectional area was found in the vertebral end-plate region and the tibial metaphysis. Notably, the diaphysis in all long bones showed expansion of periosteal and endosteal circumference. In tibia this resulted in increased cortical thickness, whereas in humerus and metatarsal it was unchanged. Areal moment of inertia was increased in all diaphyses suggesting greater bending strength. The most conspicuous finding in diabetic rats pertained to trabecular osteopenia. Thus, trabecular bone mineral density was significantly reduced in all bones examined, by 33-53%. Our pQCT study of axial and appendicular bones suggests that the typical feature of diabetic osteopathy in the GK rat is loss of trabecular bone and expansion of the diaphysis. The loss of metaphyseal trabecular bone if also present in diabetic patients may prove to underlie the susceptibility to periarticular fracture and Charcot arthropathy. The findings suggest that the risk of fracture in diabetes varies according to the specific sub-regions of a bone. The approach described may prove to be useful in the early detection of osteopathy in diabetic patients who may be amenable to preventive treatment.
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4.
  • Schacter, Daniel L., et al. (author)
  • Endel Tulving (1927-2023) [Obituary]
  • 2023
  • In: Neuron. - : Elsevier. - 0896-6273 .- 1097-4199. ; 111:22, s. 3502-3504
  • Journal article (other academic/artistic)
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5.
  • Schad, A., et al. (author)
  • A UNIFIED APPROACH TO THE HELIOSEISMIC INVERSION PROBLEM OF THE SOLAR MERIDIONAL FLOW FROM GLOBAL OSCILLATIONS
  • 2011
  • In: Astrophysical Journal. - : University of Chicago Press. - 0004-637X .- 1538-4357. ; 734:2, s. 97-
  • Journal article (peer-reviewed)abstract
    • Measurements from tracers and local helioseismology indicate the existence of a meridional flow in the Sun with strength in the order of 15 m s(-1) near the solar surface. Different attempts were made to obtain information on the flow profile at depths up to 20 Mm below the solar surface. We propose a method using global helioseismic Doppler measurements with the prospect of inferring the meridional flow profile at greater depths. Our approach is based on the perturbation of the p-mode eigenfunctions of a solar model due to the presence of a flow. The distortion of the oscillation eigenfunctions is manifested in the mixing of p-modes, which may be measured from global solar oscillation time series. As a new helioseismic measurement quantity, we propose amplitude ratios between oscillations in the Fourier domain. We relate this quantity to the meridional flow and unify the concepts presented here for an inversion procedure to infer the meridional flow from global solar oscillations.
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6.
  • Cako, Stefan, 1994- (author)
  • The Challenges of Russian Militarization in Outer Space
  • 2020
  • In: Kungl Krigsvetenskapsakademiens Handlingar och Tidskrift. - 0023-5369. ; :3, s. 149-162
  • Journal article (other academic/artistic)abstract
    • Den ständigt växande användningen av satelliter från USA har även lett till ökat beroende avdem för viktiga områden som täcker militär underrättelsetjänst liksom allt fler civila områden.Detta har inte gått obemärkt förbi, då samarbetet mellan Ryssland och Kina intensifieras genomatt samla ihop resurser och vetenskaplig expertis för och kunna undergräva och utnyttjadessa tydliga sårbarheter i rymden. Samtidigt som de framgångsrikt för fram ett effektivt narrativom att stödja fred i rymden och icke-militarisering. Artikeln utvärderar det ryska hoteti rymden i skenet av den ökande användningen av ryska gråzonsoperationer och sårbarheterför amerikanska och andra aktörers satelliter. Således sårbarheten för just sådana aktivitetervilka inom en snar framtid kommer att omfattas av att allt fler diffusa aktörer kommer attnyttja rymden i samband med pågående kommersialisering av densamma.
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10.
  • Francén, Ragnar, 1977 (author)
  • Moral Disagreement and Practical Direction
  • 2022
  • In: Journal of Ethics and Social Philosophy. - : Journal of Ethics and Social Philosophy. - 1559-3061. ; 23:2, s. 273-303
  • Journal article (peer-reviewed)abstract
    • Whenever A judges that x-ing is morally wrong and B judges that x-ing is not morally wrong, we think that they disagree. The two standard types of accounts of such moral disagreements both presuppose that the class of moral wrong-judgments is uniform, though in different ways. According to the belief account, the disagreement is doxastic: A and B have beliefs with conflicting cognitive contents. This presupposes “belief-uniformity”: that the content of moral concepts is invariant in such a way that, whenever A believes that x-ing is morally wrong and B believes that x-ing is not morally wrong, their beliefs have mutually inconsistent contents. According to the attitude account, moral disagreements are non-doxastic: A and B have clashing practical attitudes. This presupposes “attitude-uniformity”: that moral judgments are always accompanied by, or consist of, desire-like attitudes. Consequently, neither account is available if both uniformity-claims are rejected – as e.g., various forms of content-relativism do. This paper presents a new non-doxastic account of deontic moral disagreement, consistent with the rejection of both uniformity-claims. I argue first, that even if deontic moral judgments are not desires, and are not always accompanied by desires, they have practical direction in the same sense as desires: they are attitudes that one can act in accordance or discordance with. Second: deontic moral disagreement can be understood as clashes in practical direction: roughly, A and B morally disagree if, and only if, some way of acting is in accordance with A’s judgment but in discordance with B’s.
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