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Träfflista för sökning "WFRF:(Hofheinz M.) srt2:(2020-2022)"

Sökning: WFRF:(Hofheinz M.) > (2020-2022)

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  • Peugeot, A., et al. (författare)
  • Generating Two Continuous Entangled Microwave Beams Using a dc-Biased Josephson Junction
  • 2021
  • Ingår i: Physical Review X. - 2160-3308. ; 11:3
  • Tidskriftsartikel (refereegranskat)abstract
    • We show experimentally that a dc-biased Josephson junction in series with two microwave resonators emits entangled beams of microwaves leaking out of the resonators. In the absence of a stationary phase reference for characterizing the entanglement of the outgoing beams, we measure second-order coherence functions to prove the entanglement. The experimental results are found in quantitative agreement with theory, proving that the low-frequency noise of the dc bias is the main limitation for the coherence time of the entangled beams. This agreement allows us to evaluate the entropy of entanglement of the resonators, estimate the entanglement flux at their output, and to identify the improvements that could bring this device closer to a useful bright source of entangled microwaves for quantum-technological applications.
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  • Schindler, L, et al. (författare)
  • Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors
  • 2022
  • Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:19
  • Tidskriftsartikel (refereegranskat)abstract
    • Overexpression of the neurotensin receptor type 1 (NTS1R), a peptide receptor located at the plasma membrane, has been reported for a variety of malignant tumors. Thus, targeting the NTS1R with 18F- or 68Ga-labeled ligands is considered a straightforward approach towards in vivo imaging of NTS1R-expressing tumors via positron emission tomography (PET). The development of suitable peptidic NTS1R PET ligands derived from neurotensin is challenging due to proteolytic degradation. In this study, we prepared a series of NTS1R PET ligands based on the C-terminal fragment of neurotensin (NT(8–13), Arg8-Arg9-Pro10-Tyr11-Ile12-Leu13) by attachment of the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) via an Nω-carbamoylated arginine side chain. Insertion of Ga3+ in the DOTA chelator gave potential PET ligands that were evaluated concerning NTS1R affinity (range of Ki values: 1.2–21 nM) and plasma stability. Four candidates were labeled with 68Ga3+ and used for biodistribution studies in HT-29 tumor-bearing mice. [68Ga]UR-LS130 ([68Ga]56), containing an N-terminal methyl group and a β,β-dimethylated tyrosine instead of Tyr11, showed the highest in vivo stability and afforded a tumor-to-muscle ratio of 16 at 45 min p.i. Likewise, dynamic PET scans enabled a clear tumor visualization. The accumulation of [68Ga]56 in the tumor was NTS1R-mediated, as proven by blocking studies.
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