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Träfflista för sökning "WFRF:(Holland C) srt2:(2000-2004)"

Sökning: WFRF:(Holland C) > (2000-2004)

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  • Fieschi, C, et al. (författare)
  • High levels of interferon gamma in the plasma of children with complete interferon gamma receptor deficiency
  • 2001
  • Ingår i: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 107:4, s. art. no.-e48
  • Tidskriftsartikel (refereegranskat)abstract
    • We have found that children with complete interferon gamma (IFNγ) receptor deficiency, unlike patients with other genetic defects predisposing them to mycobacterial diseases, have very high levels of IFNγ in their plasma. This unexpected observation provides a simple and accurate diagnostic method for complete IFNγ receptor deficiency in children with clinical disease caused by bacille Calmette-Guérin vaccines or environmental nontuberculous mycobacteria.
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  • Uhrbom, Lene, et al. (författare)
  • Somatic cell gene transfer
  • 2004
  • Ingår i: Mouse Models Of Human Cancer. - : Wiley-Liss, Inc., Hoboken, New Jersey. - 047144460X ; , s. 474-
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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  • Wolf, Rebecca M., et al. (författare)
  • p190RhoGAP can act to inhibit PDGF-induced gliomas in mice : a putative tumor suppressor encoded on human chromosome 19q13.3.
  • 2003
  • Ingår i: Development, Genes and Evolution. - : Cold Spring Harbor Laboratory. - 0949-944X .- 1432-041X. ; 17:4, s. 476-487
  • Tidskriftsartikel (refereegranskat)abstract
    • p190RhoGAP and Rho are key regulators of oligodendrocyte differentiation. The gene encoding p190RhoGAP is located at 19q13.3 of the human chromosome, a locus that is deleted in 50%-80% of oligodendrogliomas. Here we provide evidence that p190RhoGAP may suppress gliomagenesis by inducing a differentiated glial phenotype. Using a cell culture model of autocrine loop PDGF stimulation, we show that reduced Rho activity via p190RhoGAP overexpression or Rho kinase inhibition induced cellular process extension, a block in proliferation, and reduced expression of the neural precursor marker nestin. In vivo infection of mice with retrovirus expressing PDGF and the p190 GAP domain caused a decreased incidence of oligodendrogliomas compared with that observed with PDGF alone. Independent experiments revealed that the retroviral vector insertion site in 3 of 50 PDGF-induced gliomas was within the p190RhoGAP gene. This evidence strongly suggests that p190 regulates critical components of PDGF oncogenesis and can act as a tumor suppressor in PDGF-induced gliomas by down-regulating Rho activity.
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  • Resultat 1-9 av 9

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