| 1. |
- Stattin, Pär, et al.
(författare)
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Outcomes in localized prostate cancer: National Prostate Cancer Register of Sweden follow-up study.
- 2010
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 102:13, s. 950-8
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Tidskriftsartikel (refereegranskat)abstract
- Treatment for localized prostate cancer remains controversial. To our knowledge, there are no outcome studies from contemporary population-based cohorts that include data on stage, Gleason score, and serum levels of prostate-specific antigen (PSA).
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| 2. |
- Holmberg, Jan, et al.
(författare)
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Damage Assessment of Objects of Art Correlated to Local Outdoor Climate During 300 Years
- 2011
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Ingår i: Developments in Climate Control of Historic Buildings. - 9783816786375 ; , s. 77-85
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Konferensbidrag (refereegranskat)abstract
- Skokloster castle, located north of Stockholm, has a rich collection of furnishing and decorative objects of various kinds dating back to the 17th century. The castle has no active climate control. The objective of this paper is to investigate the deterioration of selected objects correlated to outdoor climate over a 300 year period and to analyse the preservation strategy chosen at Skokloster. The results show that the selected object overall were in good condition, as the were selected to represent the whole collection this would indicate a major part of the collection has been relatively well preserved and that the strategy of “doing nothing” has been favourable.
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| 3. |
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| 4. |
- Sun, Chengjun, et al.
(författare)
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CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population
- 2012
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Ingår i: Human Immunology. - : Elsevier. - 0198-8859 .- 1879-1166. ; 73:7, s. 759-766
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.
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| 5. |
- Tilling, Kate, et al.
(författare)
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Development of a new method for monitoring prostate-specific antigen changes in men with localised prostate cancer : a comparison of observational cohorts
- 2010
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 57:3, s. 446-452
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Prostate-specific antigen (PSA) measurements are increasingly used to monitor men with localised prostate cancer (PCa), but there is little consensus about the method to use. OBJECTIVE: To apply age-specific predictions of PSA level (developed in men without cancer) to one cohort of men with clinically identified PCa and one cohort of men with PSA-detected PCa. We hypothesise that among men with clinically identified cancer, the annual increase in PSA level would be steeper than in men with PSA-detected cancer. DESIGN, SETTING, AND PARTICIPANTS: The Scandinavian Prostate Cancer Group 4 (SPCG-4) cohort consisted of 321 men assigned to the watchful waiting arm of the SPCG-4 trial. The UK cohort consisted of 320 men with PSA-detected PCa in the Prostate testing for cancer and Treatment (ProtecT) study who opted for monitoring. Multilevel models describing changes in PSA level were fitted to the two cohorts, and average PSA level at age 50, change in PSA level with age, and predicted PSA values were derived. MEASUREMENTS: PSA level. RESULTS AND LIMITATIONS: In the SPCG-4 cohort, mean PSA at age 50 was similar to the cancer-free cohort but with a steeper yearly increase in PSA level (16.4% vs 4.0%). In the UK cohort, mean PSA level was higher than that in the cancer-free cohort (due to a PSA biopsy threshold of 3.0 ng/ml) but with a similar yearly increase in PSA level (4.1%). Predictions were less accurate for the SPCG-4 cohort (median difference between observed and predicted PSA level: -2.0 ng/ml; interquartile range [IQR]: -7.6-0.7 ng/ml) than for the UK cohort (median difference between observed and predicted PSA level: -0.8 ng/ml; IQR: -2.1-0.1 ng/ml). CONCLUSIONS: In PSA-detected men, yearly change in PSA was similar to that in cancer-free men, whereas in men with symptomatic PCa, the yearly change in PSA level was considerably higher. Our method needs further evaluation but has promise for refining active monitoring protocols.
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| 7. |
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| 8. |
- Andersson, C., et al.
(författare)
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User-friendliness and transparency in PSA modelling
- 2010
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Ingår i: Proc. of PSAM 10 — International Probabilistic Safety Assessment & Management Conference, 7–11 June 2010, Seattle, Washington, USA, IAPSAM — International Association of Probabilistic Safety Assessment and Management.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Most of the probabilistic safety assessments (PSA) for Nuclear Power Plants were originally created to make conservative estimates of the core damage frequencies for internal events, which might occur during power operation. The PSA models have then been expanded to replace conservative estimates with more realistic assumptions and to include other types of initiating events, modes of operation and end states. The development has resulted in very large and detailed models, which are hard to understand completely, even for an experienced PSA engineer. Today, the trend to increase the level of detail and the scope of the PSA models continues as a consequence of regulatory requirements. Hence the Nordic PSA Group (NPSAG) has initiated a project with the aim of identifying methods to reduce the complexity of the PSA models. This paper presents and discusses the results of the first part of the project in which areas of importance for the user-friendliness and transparency of a PSA are identified.
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| 9. |
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| 10. |
- Bengtsson, Lisa, et al.
(författare)
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Probabilistic Safety Goals for Nuclear Power Plants; Phases 2-4 : Final Report
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Safety goals are defined in different ways in different countries and also used differently. Many countries are presently developing them in connection to the transfer to risk-informed regulation of both operating nuclear power plants (NPP) and new designs. However, it is far from self-evident how probabilistic safety criteria should be defined and used. On one hand, experience indicates that safety goals are valuable tools for the interpretation of results from a probabilistic safety assessment (PSA), and they tend to enhance the realism of a risk assessment. On the other hand, strict use of probabilistic criteria is usually avoided. A major problem is the large number of different uncertainties in a PSA model, which makes it difficult to demonstrate the compliance with a probabilistic criterion. Further, it has been seen that PSA results can change a lot over time due to scope extensions, revised operating experience data, method development, changes in system requirements, or increases of level of detail, mostly leading to an increase of the frequency of the calculated risk. This can cause a problem of consistency in the judgments.This report presents the results from the second, third and fourth phases of the project (2007–2009), which have dealt with providing guidance related to the resolution of some specific problems, such as the problem of consistency in judgement, comparability of safety goals used in different industries, the relationship between criteria on different levels, and relations between criteria for level 2 and 3 PSA. In parallel, additional context information has been provided. This was achieved by extending the international overview by contributing to and benefiting from a survey on PSA safety criteria which was initiated in 2006 within the OECD/NEA Working Group Risk.The results from the project can be used as a platform for discussions at the utilities on how to define and use quantitative safety goals. The results can also be used by safety authorities as a reference for risk-informed regulation. The outcome can have an impact on the requirements on PSA, e.g., regarding quality, scope, level of detail, and documen¬tation. Finally, the results can be expected to support on-going activities concerning risk-informed applications.The project provides a comprehensive state-of-the-art description and has contributed to clarifying the history of safety goals both nationally and internationally, the concepts involved in defining and applying probabilistic safety criteria, and the international status and trends in general. It has identified critical issues and the main problem areas. Finally, the project provides useful recommendations and guidance on the definition and application of criteria.Furthermore, the project makes it possible to define criteria stringently, improving the possibilities of argumentation on safety. Generally, this supports efficient use of criteria, yielding more useful PSA results. In this connection, the introduction of ALARP type criteria is judged to provide a very useful way of balancing stringency with the necessary flexibility. There is a possibility of making more active use of lower level criteria. This makes the connection to defence in depth more evident, and opens the perspective of increased control of defence in depth by use of probabilistic methods, including the use as design tools. There is an opportunity for comparison of risk of different NPPs, as well as of comparison of NPP risk with other risks in society. This is judged to provide an opportunity for improved communication on risks with non-PSA experts and with the public in general. However, a necessary condition for meaningful comparisons is to agree on the scope of PSA and methods applied.Obviously, there will also be challenges in the future definition and application of probabilistic safety criteria. These include very general aspects, such as the interpretation of the probability, quality aspects of PSA, and the definition of meaningful and consistent risk criteria for different usages. The need and usefulness of subsidiary criteria has been stressed in the project, but there is obviously also a challenge in defining a relevant set of criteria on different levels. Defining criteria for L(E)RF is complex, especially if release criteria are defined as subsidiary for societal and individual risk. Finally, it will be a challenge to develop coherent application procedures relative to the criteria defined.
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