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- Fatemi, Shahab, et al.
(författare)
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Solar wind plasma interaction with Gerasimovich lunar magnetic anomaly
- 2015
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 120:6, s. 4719-4735
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of the first local hybrid simulations (particle ions and fluid electrons) for the solar wind plasma interaction with realistic lunar crustal fields. We use a three-dimensional hybrid model of plasma and an empirical model of the Gerasimovich magnetic anomaly based on Lunar Prospector observations. We examine the effects of low and high solar wind dynamic pressures on this interaction when the Gerasimovich magnetic anomaly is located at nearly 20 degrees solar zenith angle. We find that for low solar wind dynamic pressure, the crustal fields mostly deflect the solar wind plasma, form a plasma void at very close distances to the Moon (below 20km above the surface), and reflect nearly 5% of the solar wind in charged form. In contrast, during high solar wind dynamic pressure, the crustal fields are more compressed, the solar wind is less deflected, and the lunar surface is less shielded from impinging solar wind flux, but the solar wind ion reflection is more locally intensified (up to 25%) compared to low dynamic pressures. The difference is associated with an electrostatic potential that forms over the Gerasimovich magnetic anomaly as well as the effects of solar wind plasma on the crustal fields during low and high dynamic pressures. Finally, we show that an antimoonward Hall electric field is the dominant electric field for similar to 3km altitude and higher, and an ambipolar electric field has a noticeable contribution to the electric field at close distances (<3km) to the Moon.
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| 2. |
- Lipsker, Camilla Wiwe, et al.
(författare)
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Prevalence of autism traits and attention-deficit hyperactivity disorder symptoms in a clinical sample of children and adolescents with chronic pain
- 2018
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Ingår i: Journal of Pain Research. - 1178-7090. ; 11, s. 2827-2836
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Recent research has suggested that autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) may be comorbid to pediatric chronic pain, but the empirical support is yet scarce. Therefore, the current study aimed to investigate the occurrence of traits and symptoms consistent with clinically significant ASD and ADHD in a group of children and adolescents with chronic debilitating pain and examine potential differences in pain and demographic variables between children with and without clinically significant traits and symptoms of ASD and ADHD. Patients and methods: This cross-sectional study included 146 parent-child dyads (102 girls, 111 mothers, children 8-17 years) consecutively referred to a tertiary pain clinic. Parents completed the Social Responsiveness Scale to assess autistic traits, and Conners-3 to measure symptoms of ADHD in their children. Children completed the Liibeck Pain Questionnaire to evaluate experienced pain. Results: Among children, 20 (13.7%) received scores consistent with clinically significant ASD and 29 (19.9%) received scores consistent with clinically significant ADHD, with a combined prevalence of clinically significant ASD/ADHD traits and symptoms of 26% of the total sample. Only 4.8% of children were previously diagnosed with either disorder. Among children with clinically significant ASD traits, girls were more prevalent, parents reported lower health, and the pain was more likely triggered by being in school. Among children with clinically significant ADHD symptoms, there were no gender differences and pain was more likely triggered by the family situation and new situations. No differences regarding pain intensity, duration, or frequency were found between children with and without clinically significant ASD traits or ADHD symptoms. Conclusion: Children with debilitating chronic pain, particularly girls, may present with an elevated risk of having a comorbid, possibly high-functioning, neurodevelopmental disorder. Results suggest that clinical assessment of pediatric chronic pain should include screening for neurodevelopmental disorders.
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| 4. |
- Tiklova, Katarina, et al.
(författare)
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Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development
- 2019
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Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Midbrain dopamine (mDA) neurons constitute a heterogenous group of cells that have been intensely studied, not least because their degeneration causes major symptoms in Parkinson's disease. Understanding the diversity of mDA neurons - previously well characterized anatomically - requires a systematic molecular classification at the genome-wide gene expression level. Here, we use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3, a marker for mDA neurons. Analyses include cells isolated during development up until adulthood and the results are validated by histological characterization of newly identified markers. This identifies seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons. Five of them express dopaminergic markers, while two express glutamatergic and GABAergic markers, respectively. Analysis also indicate evolutionary conservation of diversity in humans. This comprehensive molecular characterization will provide a valuable resource for elucidating mDA neuron subgroup development and function in the mammalian brain.
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