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- Chebaeva, Natalia, et al.
(författare)
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Dealing with the eco-design paradox in research and development projects : The concept of sustainability assessment levels
- 2021
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 281
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Tidskriftsartikel (refereegranskat)abstract
- Although plenty of research has been carried out to develop a multitude of sustainability assessment methods, few guidelines and criteria have been established to help practitioners and researchers find the most appropriate method for a specific case. Studies have shown the importance of integrating sustainability assessments when conducting research and development activities, but have not provided direct links to available sustainability assessment methods. To address the so-called "eco-design paradox", this paper describes a systematic classification system for the available sustainability assessment methods. To support the early integration of sustainability assessments in research and development, we inductively derived the concept of sustainability assessment levels from the well-known concept of technology readiness level. In total, 33 sustainability assessment methods were considered. We performed an expert-based correspondence analysis based on the availability of information to perform these methods and the demand for specific information at respective technology readiness level. Thereafter, a cluster analysis was performed, creating four distinct clusters which were finally interpreted as sustainability assessment levels. The provided concept supports interdisciplinary research projects in that it provides an overview of and guideline for possible sustainability assessment methods that match the respective technology readiness level. This enables researchers to integrate sustainability assessment into respective research and development projects and further modify and develop the theoretically synthetized concept based on empirical case studies.
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| 3. |
- Noc, Marko, et al.
(författare)
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A multicentre, prospective, randomised controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction : The COOL AMI EU Pivotal Trial
- 2021
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Ingår i: EuroIntervention. - 1774-024X. ; 17:6, s. 466-473
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Tidskriftsartikel (refereegranskat)abstract
- Background: Despite primary PCI (PPCI), ST-elevation myocardial infarction (STEMI) can still result in large infarct size (IS). New technology with rapid intravascular cooling showed positive signals for reduction in IS in anterior STEMI. Aims: We investigated the effectiveness and safety of rapid systemic intravascular hypothermia as an adjunct to PPCI in conscious patients, with anterior STEMI, without cardiac arrest. Methods: Hypothermia was induced using the ZOLL® Proteus™ intravascular cooling system. After randomisation of 111 patients, 58 to hypothermia and 53 to control groups, the study was prematurely discontinued by the sponsor due to inconsistent patient logistics between the groups resulting in significantly longer total ischaemic delay in the hypothermia group (232 vs 188 minutes; p<0.001). Results: There were no differences in angiographic features and PPCI result between the groups. Intravascular temperature at wire crossing was 33.3+0.9°C. Infarct size/left ventricular (IS/LV) mass by cardiac magnetic resonance (CMR) at day 4-6 was 21.3% in the hypothermia group and 20.0% in the control group (p=0.540). Major adverse cardiac events at 30 days increased non-significantly in the hypothermia group (8.6% vs 1.9%; p=0.117) while cardiogenic shock (10.3% vs 0%; p=0.028) and paroxysmal atrial fibrillation (43.1% vs 3.8%; p<0.001) were significantly more frequent in the hypothermia group. Conclusions: The ZOLL Proteus intravascular cooling system reduced temperature to 33.3°C before PPCI in patients with anterior STEMI. Due to inconsistent patient logistics between the groups, this hypothermia protocol resulted in a longer ischaemic delay, did not reduce IS/LV mass and was associated with increased adverse events.
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