Sökning: WFRF:(Hori Masatsugu)
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Dabigatran Versus W...
Dabigatran Versus Warfarin Effects on Ischemic and Hemorrhagic Strokes and Bleeding in Asians and Non-Asians With Atrial Fibrillation
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Hori, Masatsugu (författare)
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Connolly, Stuart J. (författare)
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Zhu, Jun (författare)
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Liu, Li Sheng (författare)
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Lau, Chu-Pak (författare)
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Pais, Prem (författare)
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Xavier, Denis (författare)
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Kim, Sung Soon (författare)
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Omar, Razali (författare)
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Dans, Antonio L. (författare)
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Tan, Ru San (författare)
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Chen, Jyh-Hong (författare)
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Tanomsup, Supachai (författare)
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Watanabe, Mitsunori (författare)
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Koyanagi, Masahide (författare)
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Ezekowitz, Michael D. (författare)
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Reilly, Paul A. (författare)
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- Wallentin, Lars (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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Yusuf, Salim (författare)
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(creator_code:org_t)
- 2013
- 2013
- Engelska.
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Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 44:7, s. 1891-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Purpose-Intracranial hemorrhage rates are higher in Asians than non-Asians, especially in patients receiving warfarin. This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries. Methods-There were 2782 patients (15%) from 10 Asian countries and 15 331 patients from 34 non-Asian countries. A Cox regression model, with terms for treatment, region, and their interaction was used. Results-Rates of stroke or systemic embolism in Asians were 3.06% per year on warfarin, 2.50% per year on DE 110 mg BID (DE 110), and 1.39% per year on DE 150 mg BID (DE 150); in non-Asians, the rates were 1.48%, 1.37%, and 1.06% per year with no significant treatment-by-region interactions. Hemorrhagic stroke on warfarin occurred more often in Asians than non-Asians (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.3-4.7; P=0.007), with significant reductions for DE compared with warfarin in both Asian (DE 110 versus warfarin HR, 0.15; 95% CI, 0.03-0.66 and DE 150 versus warfarin HR, 0.22; 95% CI, 0.06-0.77) and non-Asian (DE 110 versus warfarin HR, 0.37; 95% CI, 0.19-0.72 and DE 150 versus warfarin HR, 0.28; 95% CI, 0.13-0.58) patients. Major bleeding rates in Asians were significantly lower on DE (both doses) than warfarin (warfarin 3.82% per year, DE 110 2.22% per year, and DE 150 2.17% per year). Conclusions-Hemorrhagic stroke rates were higher on warfarin in Asians versus non-Asians, despite similar blood pressure, younger age, and lower international normalized ratio values. Hemorrhagic strokes were significantly reduced by DE in both Asians and non-Asians. DE benefits were consistent across Asian and non-Asian subgroups.
Nyckelord
- Asia
- atrial fibrillation
- bleeding
- dabigatran
- intracranial hemorrhage
- RE-LY
- warfarin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Stroke
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Hori, Masatsugu
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Connolly, Stuart ...
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Zhu, Jun
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Liu, Li Sheng
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Lau, Chu-Pak
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Pais, Prem
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visa fler...
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Xavier, Denis
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Kim, Sung Soon
-
Omar, Razali
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Dans, Antonio L.
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Tan, Ru San
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Chen, Jyh-Hong
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Tanomsup, Supach ...
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Watanabe, Mitsun ...
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Koyanagi, Masahi ...
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Ezekowitz, Micha ...
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Reilly, Paul A.
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Wallentin, Lars
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Yusuf, Salim
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visa färre...
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Stroke
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Uppsala universitet