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Genomic epidemiolog...
Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014
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- Demczuk, Walter (författare)
- Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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- Martin, Irene (författare)
- Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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- Peterson, Shelley (författare)
- Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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- Bharat, Amrita (författare)
- Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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- Van Domselaar, Gary (författare)
- Science Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
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- Graham, Morag (författare)
- Science Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
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- Lefebvre, Brigitte (författare)
- Laboratoire de Santé Publique du Québec, Ste-Anne-de-Bellevue QC, Canada
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- Allen, Vanessa (författare)
- Public Health Ontario Laboratories, Toronto ON, Canada
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- Hoang, Linda (författare)
- British Columbia Centres for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver BC, Canada
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- Tyrrell, Greg (författare)
- Provincial Laboratory for Public Health, Edmonton, Canada
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- Horsman, Greg (författare)
- Saskatchewan Disease Control Laboratory, Regina, Canada
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- Wylie, John (författare)
- Cadham Provincial Laboratory, Winnipeg, Canada
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- Haldane, David (författare)
- Queen Elizabeth II Health Sciences Centre, Halifax, Canada
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- Archibald, Chris (författare)
- Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Canada
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- Wong, Tom (författare)
- First Nations and Inuit Health Branch, Health Canada, Ottawa, Canada
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- Unemo, Magnus, 1970- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Mulvey, Michael R (författare)
- Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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(creator_code:org_t)
- Washington, USA : American Society for Microbiology, 2016
- 2016
- Engelska.
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Ingår i: Journal of Clinical Microbiology. - Washington, USA : American Society for Microbiology. - 0095-1137 .- 1098-660X. ; 54:5, s. 1304-1313
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The emergence of Neisseria gonorrhoeae with decreased susceptibility to cephalosporins and azithromycin resistance (AZM-R) represent a public health threat of untreatable gonorrhoea infections. Genomic epidemiology through whole genome sequencing was used to describe the emergence, dissemination, and spread of AZM-R strains. The genomes of 213 AZM-R and 23 AZM-susceptible N. gonorrhoeae isolates collected in Canada from 1989 to 2014 were sequenced. Core single nucleotide polymorphism (SNP) phylogenomic analysis resolved 246 isolates into 13 lineages. High-level AZM-R (minimum inhibitory concentration ≥256 μg/ml) was found in 5 phylogenetically diverse isolates, all of which possessed the A2059G mutation (Escherichia coli numbering) in all four 23S rRNA alleles. One high-level AZM-R isolate collected in 2009 concurrently had decreased susceptibility to ceftriaxone (MIC=0.125 μg/ml). An increase in the number of 23S rRNA alleles with the C2611T mutations (E. coli numbering) conferred low to moderate AZM-R (2 to 4 and 8 to 32 μg/mL, respectively). Low level AZM-R was also associated with mtrR promoter mutations including -35A deletion and the presence of N. meningitidis-like sequences. Geographic and temporal phylogenetic clustering indicate emergent AZM-R strains arise independently and can then rapidly expand clonally in a region through local sexual networks.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Microbiology
- Mikrobiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Demczuk, Walter
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Martin, Irene
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Peterson, Shelle ...
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Bharat, Amrita
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Van Domselaar, G ...
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Graham, Morag
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Lefebvre, Brigit ...
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Allen, Vanessa
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Hoang, Linda
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Tyrrell, Greg
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Horsman, Greg
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Wylie, John
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Haldane, David
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Archibald, Chris
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Wong, Tom
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Unemo, Magnus, 1 ...
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Mulvey, Michael ...
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- NATURVETENSKAP
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NATURVETENSKAP
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Journal of Clini ...
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Örebro universitet