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Sökning: WFRF:(Horsnell J) > (2022) > Parental TB associa...

Parental TB associated with offspring asthma and rhinitis

Lopez-Cervantes, J. P. (författare)
Univ Bergen, Norway; Haukeland Hosp, Norway
Shigdel, R. (författare)
Univ Bergen, Norway
Accordini, S. (författare)
Univ Verona, Italy
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Mustafa, T. (författare)
Univ Bergen, Norway
Bertelsen, R. J. (författare)
Univ Bergen, Norway
Makvandi-Nejad, S. (författare)
Univ Bergen, Norway; Haukeland Hosp, Norway
Lerm, Maria, Professor, 1973- (författare)
Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
Horsnell, W. (författare)
Univ Cape Town, South Africa; Univ Birmingham, England
Svanes, C. (författare)
Univ Bergen, Norway; Haukeland Hosp, Norway
visa färre...
 (creator_code:org_t)
Paris, France : International Union Against Tuberculosis and Lung Disease, 2022
2022
Engelska.
Ingår i: The International Journal of Tuberculosis and Lung Disease. - Paris, France : International Union Against Tuberculosis and Lung Disease. - 1027-3719 .- 1815-7920. ; 26:6, s. 544-549
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Infections in early life are associated with asthma and allergies in one-generation settings; however, the link between parental infection and offspring phenotype is rarely investigated. We aim to study the association of parental TB before conception of the offspring with offspring asthma and rhinitis.METHODS: We included 2,965 offspring born in 1985- 2004 and registered in the Norwegian prescription database to 1,790 parents born after 1960 with a history of TB, and included in the Norwegian TB registry. Offspring asthma (n = 582) and rhinitis (n = 929) were defined based on diagnosis, type of medication and prescribed medication >1 year. Associations of parental TB ,8 years, >8 years but before offsprings birth year and after birth (reference category) with offspring asthma and rhinitis were analysed using logistic regression.RESULTS: Asthma risk was higher in persons with parental TB in childhood (OR 1.73, 95% CI 1.20- 2.50) or later preconception (OR 1.38, 95% CI 1.00- 1.91) than in persons with parental TB after offsprings birth; this was significant only in the maternal line (childhood: OR 1.95, 95% CI 1.13-3.37; later precon-ception: OR 1.74, 95% CI 1.08-2.80). Associations with rhinitis were not identified.CONCLUSIONS: Parental childhood TB was associated with higher asthma risk in future offspring. We speculate that TB impacts maternal immunity , dysregulates the offsprings type 2 immunity , that TB-induced epigenetic reprograming of immune defences are trans-ferred to the offspring.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

infections; preconception; intergenera-tional; NCDs

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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