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Time course changes...
Time course changes to structural, mechanical and material properties of bone in rats after complete spinal cord injury
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- Williams, Jonathan A. (författare)
- University of Strathclyde
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- Huesa, Carmen (författare)
- University of the West of Scotland
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- Turunen, Mikael J. (författare)
- University of Eastern Finland
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- Oo, James A. (författare)
- Goethe University
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- Radzins, Oskars (författare)
- University of Glasgow
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- Gardner, Wilf (författare)
- University of Glasgow
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- Windmill, James F.C. (författare)
- University of Strathclyde
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- Isaksson, Hanna (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LTH profilområde: Teknik för hälsa,Other operations, LTH,Faculty of Engineering, LTH,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,Faculty of Engineering, LTH
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- Tanner, K. Elizabeth (författare)
- Lund University,Lunds universitet,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Glasgow
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- Riddell, John S. (författare)
- University of Glasgow
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- Coupaud, Sylvie (författare)
- University of Strathclyde
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(creator_code:org_t)
- 2022
- 2022
- Engelska 23 s.
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Ingår i: Journal of Musculoskeletal Neuronal Interactions. - 1108-7161. ; 22:2, s. 212-234
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- Objective: Characterise the spatiotemporal trabecular and cortical bone responses to complete spinal cord injury (SCI) in young rats. Methods: 8-week-old male Wistar rats received T9-transection SCI and were euthanised 2-, 6-, 10-or 16-weeks post-surgery. Outcome measures were assessed using micro-computed tomography, mechanical testing, serum markers and Fourier-transform infrared spectroscopy. Results: The trabecular and cortical bone responses to SCI are site-specific. Metaphyseal trabecular BV/TV was 59% lower, characterised by fewer and thinner trabeculae at 2-weeks post-SCI, while epiphyseal BV/TV was 23% lower with maintained connectivity. At later-time points, metaphyseal BV/TV remained unchanged, while epiphyseal BV/TV increased. The total area of metaphyseal and mid-diaphyseal cortical bone were lower from 2-weeks and between 6-and 10-weeks post-SCI, respectively. This suggested that SCI-induced bone changes observed in the rat model were not solely attributable to bone loss, but also to suppressed bone growth. No tissue mineral density differences were observed at any time-point, suggesting that decreased whole-bone mechanical properties were primarily the result of changes to the spatial distribution of bone. Conclusion: Young SCI rat trabecular bone changes resemble those observed clinically in adult and paediatric SCI, while cortical bone changes resemble paediatric SCI only.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Bone Mechanical Properties
- Fourier-transform Infrared Spectroscopy
- microCT
- Osteoporosis
- Spinal Cord Transection
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Till lärosätets databas
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Williams, Jonath ...
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Huesa, Carmen
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Turunen, Mikael ...
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Oo, James A.
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Radzins, Oskars
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Gardner, Wilf
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visa fler...
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Windmill, James ...
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Isaksson, Hanna
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Tanner, K. Eliza ...
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Riddell, John S.
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Coupaud, Sylvie
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Journal of Muscu ...
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Lunds universitet