Search: WFRF:(Hughes Alan)
> (2004) >
Transcobalamin poly...
Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
-
McCaddon, Andrew (author)
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
-
Hudson, Peter (author)
-
show more...
-
Hughes, Alan (author)
-
Barber, Joan (author)
-
Gray, Rob (author)
-
Davies, Gareth (author)
-
Williams, John H.H. (author)
-
Duguid, Jennifer (author)
-
Lloyd, Alwyn (author)
-
Tandy, Steve (author)
-
Everall, Marge (author)
-
Cattell, Howard (author)
-
McCaddon, Anne (author)
-
Ellis, Dick (author)
-
- Palmér, Mona, 2000 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
-
- Bogdanovic, Nenad (author)
- Karolinska Institutet
-
- Gottfries, Carl-Gerhard, 1928 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
-
- Rymo, Lars, 1940 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
-
- Regland, Björn, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
-
show less...
-
(creator_code:org_t)
- 2004-03-17
- 2004
- English.
-
In: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 17:3, s. 215-221
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Isoforms of the vitamin B<sub>12</sub> carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer’s disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox’s F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox’s F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- methylenetetrahydrofolate reductase
- risk factor
- codon-259 polymorphism
- genetic-polymorphism
- plasma homocysteine
- common mutation
- ii isoproteins
- dementia
- vitamin-b12
- deficiency
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
McCaddon, Andrew
-
Blennow, Kaj, 19 ...
-
Hudson, Peter
-
Hughes, Alan
-
Barber, Joan
-
Gray, Rob
-
show more...
-
Davies, Gareth
-
Williams, John H ...
-
Duguid, Jennifer
-
Lloyd, Alwyn
-
Tandy, Steve
-
Everall, Marge
-
Cattell, Howard
-
McCaddon, Anne
-
Ellis, Dick
-
Palmér, Mona, 20 ...
-
Bogdanovic, Nena ...
-
Gottfries, Carl- ...
-
Zetterberg, Henr ...
-
Rymo, Lars, 1940
-
Regland, Björn, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Geriatrics
- Articles in the publication
-
Dementia and Ger ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet