| 1. |
- Ahola, Virpi, et al.
(författare)
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The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera
- 2014
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 4737-
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have reported that chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we report the genome (393 Mb) of the Glanville fritillary butterfly (Melitaea cinxia; Nymphalidae), a widely recognized model species in metapopulation biology and eco-evolutionary research, which has the putative ancestral karyotype of n = 31. Using a phylogenetic analyses of Nymphalidae and of other Lepidoptera, combined with orthologue-level comparisons of chromosomes, we conclude that the ancestral lepidopteran karyotype has been n = 31 for at least 140 My. We show that fusion chromosomes have retained the ancestral chromosome segments and very few rearrangements have occurred across the fusion sites. The same, shortest ancestral chromosomes have independently participated in fusion events in species with smaller karyotypes. The short chromosomes have higher rearrangement rate than long ones. These characteristics highlight distinctive features of the evolutionary dynamics of butterflies and moths.
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| 2. |
- Deiaco, Enrico, et al.
(författare)
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Universities as Strategic Actors in the Knowlege Economy
- 2012
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Ingår i: Cambridge Journal of Economics. - 1464-3545 .- 0309-166X. ; 36:3, s. 525-541
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Tidskriftsartikel (refereegranskat)abstract
- The university plays a particular role in the global knowledge economy, as provider of both public and private goods related to education, research, and societal impacts. At the same time, universities in the plural play many different roles, and exhibit a rich experimentation in organizational forms and knowledge foci, adapting to local and global conditions. There is also an aspect of uneven regional development and agglomeration of competencies, as the individuals and organizations must also balance local interests and stakeholders with global networks in science, technology and innovation. Thus, we can identify empirically that universities are changing their strategies, organizational structures and competencies, in order to respond to new external demands and internal management practices (Bonaccorsi and Daraio 2007). The question is how to explain this theoretically and identify empirical trends and pathways. Little previous research has focused upon how universities are learning to compete and why they try to act strategically. This article, as well as the selected articles in the special issue, focus upon how and why this transition is occurring as well as the impacts for understanding universities as strategic actors in the knowledge economy. Section 2 provides an overview. It introduces the three themes and articles collected in this special issue, providing a summary of the main contributions. Section 3 then provides our perspective on how to analyze and understand universities as strategic actors. It discusses relevant literature, as a way of beginning to provide our perspective of the necessity, and elements involved, in a more united theoretical and empirical understanding. This includes statement of predictions, as well as empirical evidence that these trends are occurring. Section 4 concludes with relevant research themes for the future
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| 3. |
- O'Seaghdha, Conall M., et al.
(författare)
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Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
- 2013
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 9:9, s. e1003796-
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Tidskriftsartikel (refereegranskat)abstract
- Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
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