| 1. |
- Fava, Cristiano, et al.
(författare)
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Novel mutations in the SLC12A3 gene causing Gitelman's syndrome in Swedes
- 2007
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Ingår i: DNA Sequence. - : Informa UK Limited. - 1029-2365 .- 1042-5179. ; 18:5, s. 395-399
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Gitelman's syndrome (GS) is an inherited autosomal recessive disorder due to loss of function mutations in the SLC12A3 gene encoding the Na-Cl co-transporter (NCCT), the target of thiazide diuretics. The defective function of the NCCT, which normally is expressed in the apical membrane of the distal convolute tubule in the kidney, leads to mild hypotension, hypokalemia, hyperreninemic hyperaldosteronism, mild metabolic alkalosis, hypomagnesemia and hypocalciuria. Up to now, more than 100 mutations of the SLC12A3 gene have been described in GS patients. METHODS: We have collected 30 patients from Sweden with a clinical diagnosis of GS and undertaken a mutation screening by SSCP and successive sequencing of the 26 exons and intronic boundaries. Both mutations were identified in most (n = 28, 93%) and at least one mutation was identified in all patients. RESULTS: We found 22 different mutations evenly distributed throughout the gene, 11 of which have not been described previously. The new variants include 8 missense mutations (Glu68Lys, His69Asn, Argl45His, Vall53Met, Gly230Asp, Gly342Ala, Val677Leu and Gly867Ser), 1 insertion (c.834_835insG on exon 6) and 2 splice-site mutations (c.2667 + lT>G substitution in splicing donor site after exon 22, c.1569-1G>A substitution in the splicing acceptor site before exon 13). CONCLUSION: In Swedish patients with the clinical features of GS, disease-causing mutations in the SLC12A3 gene were identified in most patients. The spectrum of GS mutations is wide making full mutation screening of the SLC12A3 gene necessary to confirm the diagnosis.
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| 2. |
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| 3. |
- Andersson, M, et al.
(författare)
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Adequate iodine nutrition in Sweden: a cross-sectional national study of urinary iodine concentration in school-age children.
- 2009
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Ingår i: European journal of clinical nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 63:7, s. 828-34
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Tidskriftsartikel (refereegranskat)abstract
- Background/Objectives:Sweden has a long-standing salt iodization program; however, its effects on iodine intake have never been monitored on a national level. The objective of this study was to evaluate iodine nutrition in the Swedish population by measuring the urinary iodine concentration (UIC) in a national sample of Swedish school-age (6-12 years of age) children.Subjects/Methods:A stratified probability proportionate to size cluster sampling method was used to obtain a representative national sample of school-age children from 30 clusters. Spot urine samples were collected for UIC analysis using a modified Sandell-Kolthoff method.Results:The median UIC of the children (n=857) was 125 mug/l (range 11-757 mug/l). The proportion of children with a UIC <100 mug/l was 30.0% and the proportion of children with a UIC <50 and >300 mug/l was 5.5 and 3.0%, respectively.Conclusions:The iodine nutritional status of the Swedish population is adequate. Iodized table salt remains the main dietary source of iodine in Swedish diet. Recommendations to reduce total salt intake in the population urge increased use of iodized salt in the production of processed foods. Pregnant and lactating women with high iodine requirements may still be at risk for low iodine intake. This study will serve as the basis for future monitoring of iodine nutritional status in Sweden.European Journal of Clinical Nutrition advance online publication, 10 September 2008; doi:10.1038/ejcn.2008.46.
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| 4. |
- Arvidsson, Daniel, 1974, et al.
(författare)
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Energy Cost in Children Assessed by Multisensor Activity Monitors
- 2009
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Ingår i: Medicine & Science in Sports & Exercise. - : American College of Sports Medicine. - 0195-9131 .- 1530-0315. ; 41:3, s. 603-611
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The SenseWear Pro2 Armband (SWA; BodyMedia, Inc., Pittsburg, PA), the Intelligent Device for Energy Expenditure and Activity (IDEEA; Minisun LLC, Fresno, CA), and the ActiReg (AR; PreMed AS, Oslo, Norway) were compared with indirect calorimetry to determine the ability of these devices to assess energy cost in children during resting and different physical activities. Methods: Fourteen children, 11–13 yr old, wore the SWA, the IDEEA, and the AR during resting, sitting, stationary bicycling, jumping on a trampoline, playing basketball, stair walking, and walking/running along a 50-m track. The Oxycon Mobile portable metabolic system (VIASYS Healthcare, Conshohocken, PA) was used as the criterion method for energy cost. Results: For resting and sitting, the three activity monitors showed comparable results, but none of them accurately assessed energy cost for stationary bicycling, jumping on a trampoline, or playing basketball. The IDEEA was the only activity monitor that accurately assessed energy cost for stair walking. Also, the IDEEA showed a close estimate of energy cost across the walking and the running intensities, whereas the SWA accurately assessed energy cost for slow to normal walking but showed increased underestimation of energy cost with increasing speed. The AR overestimated energy cost during walking and during slow running but did not respond to increasing running speed. Conclusions: To be able to capture children’s physical activity, all three activity monitors need to be further developed. Overall, the IDEEA showed the highest ability to assess energy cost in this study, but SWA may be more feasible for use in children under free-living conditions.
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| 5. |
- Arvidsson, Daniel, 1974, et al.
(författare)
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Energy cost of physical activities in children : Validation of SenseWear Armband
- 2007
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Ingår i: Medicine & Science in Sports & Exercise. - : American College of Sports Medicine. - 0195-9131 .- 1530-0315. ; 39:11, s. 2076-2084
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To examine the validity of SenseWear Pro2 Armband in assessing energy cost of physical activities in children, and to contribute with values of energy costs in an overview of physical activities in children. METHODS: Energy cost was assessed by SenseWear Pro2 Armband in 20 healthy children, 11-13 yr, while lying down resting, sitting playing games on mobile phone, stepping up and down on a step board, bicycling on a stationary bike, jumping on a trampoline, playing basketball, and walking/running on a treadmill at the speeds 2, 3, 4, 5, 6, 7, 8, and 10 km x h(-1). During these activities, energy cost was also assessed from VO2 and VCO2 measured by Oxycon Mobile portable metabolic system, which was used as criterion method. RESULTS: The difference in energy cost between SenseWear Pro2 Armband and Oxycon Mobile was -0.7 (0.5) (P < 0.001) for resting, -2.0 (0.9) (P < 0.001) for playing games on mobile phone, -6.6 (2.3) (P < 0.001) for stepping on the step board, -12.0 (3.7) (P < 0.001) for bicycling, -2.7 (11.9) (P = 0.34) for jumping on the trampoline, and -14.8 (6.4) kJ x min(-1) (P < 0.001) for playing basketball. The difference in energy cost between SenseWear Pro2 Armband and Oxycon Mobile for increasing treadmill speed was 1.3 (3.1) (P = 0.048), 0.1 (2.9) (P = 0.82), -1.2 (2.6) (P = 0.049), -1.6 (3.2) (P = 0.044), -3.1 (3.7) (P = 0.0013), -4.9 (3.7) (P < 0.001), -5.3 (3.7) (P < 0.001), and -11.1 (3.5) kJ x min(-1) (P < 0.001). CONCLUSIONS: SenseWear Pro2 Armband underestimated energy cost of most activities in this study, an underestimation that increased with increased physical activity intensity. A table of energy costs (MET values) of physical activities in children measured by indirect calorimetry is presented as an initiation of the creation of a compendium of physical activities in children
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| 6. |
- Arvidsson, Daniel, 1974, et al.
(författare)
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Free-living energy expenditure in children using multi-sensor activity monitors.
- 2009
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Ingår i: Clinical nutrition (Edinburgh, Scotland). - : Elsevier BV. - 1532-1983 .- 0261-5614. ; 28:3, s. 305-12
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: To improve the energy expenditure algorithm of the activity monitor ActiReg, and to validate ActiReg and the activity monitor SenseWear in free-living children. METHODS: The development of the ActiReg algorithm was performed in 20 healthy 11-13 years old children on treadmill walking and running with indirect calorimetry as reference. The original and new ActiReg algorithms and SenseWear using software versions InnerView 5.1 and 6.1 were validated in 20 healthy 14-15 years old children against doubly labelled water. RESULTS: The new ActiReg algorithm improved the assessment of energy expenditure during walking and running, but the response from the monitor levelled off after 7 km h(-1). The new algorithm and InnerView 6.1 decreased the mean (sd) difference to doubly labelled water from 11 (25) (P<0.05) to 0 (22) kJ kg(-1) d(-1) for ActiReg, and from 17 (20) (P<0.01) to -10 (21) (P<0.05) kJ kg(-1) d(-1) for SenseWear. However, the correlations between energy expenditure and the individual error for the new ActiReg algorithm and InnerView 6.1 were r= -0.50 (P<0.05) and r= -0.73 (P<0.01). CONCLUSIONS: The new ActiReg algorithm and InnerView 6.1 improved the activity monitors at group level, but the error was dependent on physical activity level. Both activity monitors need further developments for use in children.
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| 7. |
- Arvidsson, Daniel, 1974, et al.
(författare)
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Physical activity questionnaire for adolescents validated against doubly labelled water
- 2005
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Ingår i: Eur J Clin Nutr. ; 59:3, s. 376-83
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To validate a physical activity questionnaire for adolescents (PAQA) adapted from the International Physical Activity Questionnaire (IPAQ). DESIGN: Energy expenditure was measured during a 14-day period with doubly labelled water (DLW). PAQA was administered as an interview at the end of the period, asking for physical activity in school, during transportation and leisure-time, during a habitual week. Energy expenditure (EE(PAQA)) was calculated as the product of total physical activity + sleep and predicted resting metabolic rate, and was compared to energy expenditure from DLW (EE(DLW)), thermic effect of feeding excluded. SETTING: Participants were recruited from grade 9 in a compulsory school in Goteborg, Sweden. All data were collected at school, and distribution of DLW and measuring of resting metabolic rate were performed at Sahlgrenska University Hospital. SUBJECTS: A total of 33 adolescents (16 girls, 17 boys) 15.7 (0.4) y performed all measurements. RESULTS:: For the whole group, PAQA underestimated energy expenditure by 3.8 (1.7) MJ (P<0.001). There was a strong correlation (r = 0.62, P<0.001) between EE(PAQA) and EE(DLW), but not for boys (r = 0.42, P = 0.090) and girls (r = 0.33, P = 0.22) separately. CONCLUSIONS: PAQA is not able to predict energy expenditure in Swedish adolescents, largely explained by the amount of unreported time. The ability to rank adolescents energy expenditure is questioned because of the gender effect, although we found a strong correlation for the whole group.
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| 8. |
- Arvidsson, Daniel, 1974, et al.
(författare)
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Physical activity, sports participation and aerobic fitness in children who have undergone surgery for congenital heart defects.
- 2009
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 1651-2227 .- 0803-5253. ; 98:9, s. 1475-82
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To investigate physical activity, sports participation and aerobic fitness in children who have undergone surgery for congenital heart defects. SUBJECTS AND METHODS: Children who had undergone surgery for congenital heart defects and healthy controls in the Gothenburg area were invited to participate in the study. All participants were aged 9-11 or 14-16 years. The activity monitor ActiReg was used to assess physical activity. Participants were interviewed about their participation in sports and performed a maximal exercise test on a bicycle with measured oxygen uptake. RESULTS: A total of 32 and 25 patients, and 61 and 45 controls, in the two age-groups were included, respectively. The patients had a wide range of severity of congenital heart defects. The physical activity level was similar in the patients and the controls. The rate of sports participation was high for both patients and controls; 80-94% of all participants took part in sports at least once a week. The majority of the patients were considered to have at least a moderate level of aerobic fitness. CONCLUSIONS: Although children who have undergone surgery for congenital heart defects have a similar level of physical activity compared with that of healthy children, some of them may require support to participate in exercise and vigorous physical activity.
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| 9. |
- Arvidsson, Daniel, 1974, et al.
(författare)
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Validity of the ActiReg system in assessing energy requirement in chronic obstructive pulmonary disease patients
- 2006
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Ingår i: Clin Nutr. ; 25:1, s. 68-74
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Malnutrition and weight loss are common in patients with chronic obstructive pulmonary disease (COPD) and effective nutritional support relies on accurate assessment of energy requirement. This could only be performed by measuring energy expenditure using objective methods. The aim of this study was to examine the validity of the ActiReg system in assessing energy requirement in non-hospitalized patients with severe COPD, using doubly labelled water (DLW) as criterion method. METHODS: Total energy expenditure (TEE) was assessed from 14 days DLW analysis in 13 patients. During the first 7 days TEE was simultaneously assessed using the ActiReg system, combining measured resting energy expenditure (REE) with physical activity monitoring. RESULTS: A difference of -88 (782) kJ d(-1) (P = 0.69) was observed between the ActiReg system and DLW. REE explained 52% of the variation in TEE from DLW. Adding physical activity energy expenditure from the ActiReg system (PAEE(AR) = TEE(AR)-REE) increased the explained variation in TEE from DLW with 16%. CONCLUSIONS: The ActiReg system is valid in assessing energy requirement in non-hospitalized patients with severe COPD. The unique feature of being able to discriminate within both the low intensity activity range and moderate-to-high intensity activity range makes the ActiReg system a valuable tool in clinical nutritional support.
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| 10. |
- Cederholm, Tommy, et al.
(författare)
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Forskaren, samhället och jäv
- 2008
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Ingår i: Läkartidningen. - 0023-7205. ; 105:16, s. 7-1206
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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