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Träfflista för sökning "WFRF:(Hwang Michael) srt2:(2006-2009)"

Sökning: WFRF:(Hwang Michael) > (2006-2009)

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1.
  • Chuang, Susan S., et al. (författare)
  • Personality development from childhood to adolescence: A longitudinal study of ego-control and ego-resiliency in Sweden
  • 2006
  • Ingår i: INTERNATIONAL JOURNAL OF BEHAVIORAL DEVELOPMENT. - : SAGE Publications. - 0165-0254 .- 1464-0651. ; 30:4, s. 338-343
  • Tidskriftsartikel (refereegranskat)abstract
    • We investigated the development of ego-control (EC) and ego-resiliency (ER) over a 13-year period in a cohort of Swedish children first assessed at 2 years of age. Children became more ego-controlled over time although individual differences in EC remained stable. Children’s levels of resiliency increased from 2 to 3 years of age and then declined when they were 7 and 8 years of age. Boys continued to become less resilient in adolescence whereas girls became more resilient. Individual differences in boys’ resiliency levels were more stable over the 13-year span than girls’. The inter-correlations between EC and ER were only significant for boys at 2 and 15 years of age. The external validity of EC and ER was demonstrated by significant associations with ratings of the children’s adaptation to school as well as with their measures of their internalizing and externalizing behavior problems.
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2.
  • Grim, Jonathan E., et al. (författare)
  • Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase
  • 2008
  • Ingår i: Journal of Cell Biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 181:6, s. 913-920
  • Tidskriftsartikel (refereegranskat)abstract
    • The SCF(FBW7) ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that each has unique functions. We used gene targeting to create isoform-specific Fbw7-null mutations in human cells and found that the nucleoplasmic Fbw7alpha isoform accounts for almost all Fbw7 activity toward cyclin E, c-Myc, and sterol regulatory element binding protein 1. Cyclin E sensitivity to Fbw7 varies during the cell cycle, and this correlates with changes in cyclin E-cyclin-dependent kinase 2 (CDK2)-specific activity, cyclin E autophosphorylation, and CDK2 inhibitory phosphorylation. These data suggest that oscillations in cyclin E-CDK2-specific activity during the cell cycle regulate the timing of cyclin E degradation. Moreover, they highlight the utility of adeno-associated virus-mediated gene targeting in functional analyses of complex loci.
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