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Personalized intervention based on early detection of atherosclerosis : JACC state-of-the-art review

Nielsen, Rikke V. (author)
Department of Medical Science, Novo Nordisk Foundation, Hellerup, Denmark; Department of Cardiothoracic Anesthesiology, Rigshospitalet University Hospital Copenhagen, Copenhagen, Denmark
Fuster, Valentin (author)
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Mount Sinai Fuster Heart Hospital, NY, New York, United States
Bundgaard, Henning (author)
Department of Cardiology, Rigshospitalet University Hospital Copenhagen, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Fuster, Jose J. (author)
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; , CIBER en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain
Johri, Amer M. (author)
Department of Medicine Queen's University, ON, Kingston, Canada
Kofoed, Klaus F. (author)
Department of Cardiology, Rigshospitalet University Hospital Copenhagen, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Radiology, Rigshospitalet University Hospital Copenhagen, Copenhagen, Denmark
Douglas, Pamela S. (author)
Duke University School of Medicine, Duke Clinical Research Institute, NC, Durham, United States
Diederichsen, Axel (author)
Department of Cardiology, Odense University Hospital, Odense, Denmark
Shapiro, Michael D. (author)
Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Disease, Wake Forest University School of Medicine, NC, Winston-Salem, United States
Nicholls, Stephen J. (author)
Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia
Nordestgaard, Børge G. (author)
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry and The Copenhagen General Population Study, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark
Lindholt, Jes S. (author)
Department of Cardiothoracic and Vascular Surgery, Elite Research Centre of Individualised Treatment of Arterial Disease (CIMA), Odense University Hospital, University of Southern Denmark, Odense, Denmark
MacRae, Calum (author)
Harvard Medical School, Department of Medicine, MA, Boston, United States
Yuan, Chun (author)
Department of Radiology and Imaging Sciences, Spencer Fox Eccles School of Medicine, University of Utah, UT, Salt Lake City, United States
Newby, David E. (author)
Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
Urbina, Elaine M. (author)
Preventive Cardiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, OH, Cincinnati, United States
Bergström, Göran (author)
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden
Ridderstråle, Martin (author)
Department of Medical Science, Novo Nordisk Foundation, Hellerup, Denmark
Budoff, Matthew J. (author)
Department of Medicine, Lundquist Institute at Harbor-UCLA, CA, Torrance, United States
Bøttcher, Morten (author)
University Clinic for Cardiovascular Research, Department of Cardiology, Aarhus University/Gødstrup Hospital, Aarhus, Denmark
Raitakari, Olli T. (author)
Centre for Population Health Research, Research Centre of Applied and Preventive Cardiovascular Medicine, InFLAMES Research Flagship, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
Hansen, Thomas H. (author)
Department of Cardiology, Rigshospitalet University Hospital Copenhagen, Copenhagen, Denmark
Näslund, Ulf (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Sillesen, Henrik (author)
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Eldrup, Nikolaj (author)
Department of Vascular Surgery, Rigshospitalet University Hospital Copenhagen, Copenhagen, Denmark
Ibanez, Borja (author)
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; , CIBER en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Cardiology Department, IIS-Fundación Jiménez Díaz University Hospital, Madrid, Spain
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 (creator_code:org_t)
Elsevier, 2024
2024
English.
In: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 83:21, s. 2112-2127
  • Research review (peer-reviewed)
Abstract Subject headings
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  • Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide and challenges the capacity of health care systems globally. Atherosclerosis is the underlying pathophysiological entity in two-thirds of patients with CVD. When considering that atherosclerosis develops over decades, there is potentially great opportunity for prevention of associated events such as myocardial infarction and stroke. Subclinical atherosclerosis has been identified in its early stages in young individuals; however, there is no consensus on how to prevent progression to symptomatic disease. Given the growing burden of CVD, a paradigm shift is required—moving from late management of atherosclerotic CVD to earlier detection during the subclinical phase with the goal of potential cure or prevention of events. Studies must focus on how precision medicine using imaging and circulating biomarkers may identify atherosclerosis earlier and determine whether such a paradigm shift would lead to overall cost savings for global health.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

atherosclerosis
cardiovascular disease
imaging
precision medicine
primary prevention

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