Search: WFRF:(Iliff Jeffrey J.)
> (2018) >
Aquaporin-4-depende...
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
-
- Mestre, Humberto (author)
- University of Rochester
-
- Hablitz, Lauren M. (author)
- University of Rochester
-
- Xavier, Anna Lr (author)
- University of Copenhagen
-
show more...
-
- Feng, Weixi (author)
- Nanjing Medical University
-
- Zou, Wenyan (author)
- Nanjing Medical University
-
- Pu, Tinglin (author)
- Nanjing Medical University
-
- Monai, Hiromu (author)
- RIKEN Center for Brain Science,Ochanomizu University
-
- Murlidharan, Giridhar (author)
- University of North Carolina
-
- Castellanos Rivera, Ruth M. (author)
- University of North Carolina
-
- Simon, Matthew J. (author)
- Oregon Health & Science University
-
- Pike, Martin M. (author)
- Oregon Health & Science University
-
- Plá, Virginia (author)
- University of Rochester
-
- Du, Ting (author)
- University of Rochester
-
- Kress, Benjamin T. (author)
- University of Rochester
-
- Wang, Xiaowen (author)
- RIKEN Center for Brain Science
-
- Plog, Benjamin A. (author)
- University of Rochester
-
- Thrane, Alexander S. (author)
- University of Copenhagen,Haukeland University Hospital
-
- Lundgaard, Iben (author)
- Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Rochester
-
- Abe, Yoichiro (author)
- Keio University
-
- Yasui, Masato (author)
- Keio University
-
- Thomas, John H. (author)
- University of Rochester
-
- Xiao, Ming (author)
- Nanjing Medical University
-
- Hirase, Hajime (author)
- Saitama University,RIKEN Center for Brain Science
-
- Asokan, Aravind (author)
- University of North Carolina,Duke University
-
- Iliff, Jeffrey J. (author)
- Oregon Health & Science University
-
- Nedergaard, Maiken (author)
- University of Rochester,University of Copenhagen
-
show less...
-
(creator_code:org_t)
- 2018
- 2018
- English.
-
In: eLife. - 2050-084X. ; 7
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.7...
-
show less...
Abstract
Subject headings
Close
- The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). Prompted by a recent failure to find an effect of Aqp4 knock-out (KO) on CSF and interstitial fluid (ISF) tracer transport, five groups re-examined the importance of AQP4 in glymphatic transport. We concur that CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO). Meta-analysis of all studies demonstrated a significant decrease in tracer transport in KO mice and rats compared to controls. Meta-regression indicated that anesthesia, age, and tracer delivery explain the opposing results. We also report that intrastriatal injections suppress glymphatic function. This validates the role of AQP4 and shows that glymphatic studies must avoid the use of invasive procedures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- aquaporin-4
- cerebrospinal fluid
- glymphatic
- meta-analysis
- mouse
- neuroscience
- replication study
- solute transport
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
eLife
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Mestre, Humberto
-
Hablitz, Lauren ...
-
Xavier, Anna Lr
-
Feng, Weixi
-
Zou, Wenyan
-
Pu, Tinglin
-
show more...
-
Monai, Hiromu
-
Murlidharan, Gir ...
-
Castellanos Rive ...
-
Simon, Matthew J ...
-
Pike, Martin M.
-
Plá, Virginia
-
Du, Ting
-
Kress, Benjamin ...
-
Wang, Xiaowen
-
Plog, Benjamin A ...
-
Thrane, Alexande ...
-
Lundgaard, Iben
-
Abe, Yoichiro
-
Yasui, Masato
-
Thomas, John H.
-
Xiao, Ming
-
Hirase, Hajime
-
Asokan, Aravind
-
Iliff, Jeffrey J ...
-
Nedergaard, Maik ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
eLife
- By the university
-
Lund University