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- Namkoong, H, et al.
(författare)
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DOCK2 is involved in the host genetics and biology of severe COVID-19
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 609:7928, s. 754-
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Tidskriftsartikel (refereegranskat)abstract
- Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1–5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.
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- Muscarella, Robert, et al.
(författare)
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The global abundance of tree palms
- 2020
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Ingår i: Global Ecology and Biogeography. - : Wiley. - 1466-822X .- 1466-8238. ; 29:9, s. 1495-1514
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Tidskriftsartikel (refereegranskat)abstract
- AimPalms are an iconic, diverse and often abundant component of tropical ecosystems that provide many ecosystem services. Being monocots, tree palms are evolutionarily, morphologically and physiologically distinct from other trees, and these differences have important consequences for ecosystem services (e.g., carbon sequestration and storage) and in terms of responses to climate change. We quantified global patterns of tree palm relative abundance to help improve understanding of tropical forests and reduce uncertainty about these ecosystems under climate change.LocationTropical and subtropical moist forests.Time periodCurrent.Major taxa studiedPalms (Arecaceae).MethodsWe assembled a pantropical dataset of 2,548 forest plots (covering 1,191 ha) and quantified tree palm (i.e., ≥10 cm diameter at breast height) abundance relative to co‐occurring non‐palm trees. We compared the relative abundance of tree palms across biogeographical realms and tested for associations with palaeoclimate stability, current climate, edaphic conditions and metrics of forest structure.ResultsOn average, the relative abundance of tree palms was more than five times larger between Neotropical locations and other biogeographical realms. Tree palms were absent in most locations outside the Neotropics but present in >80% of Neotropical locations. The relative abundance of tree palms was more strongly associated with local conditions (e.g., higher mean annual precipitation, lower soil fertility, shallower water table and lower plot mean wood density) than metrics of long‐term climate stability. Life‐form diversity also influenced the patterns; palm assemblages outside the Neotropics comprise many non‐tree (e.g., climbing) palms. Finally, we show that tree palms can influence estimates of above‐ground biomass, but the magnitude and direction of the effect require additional work.ConclusionsTree palms are not only quintessentially tropical, but they are also overwhelmingly Neotropical. Future work to understand the contributions of tree palms to biomass estimates and carbon cycling will be particularly crucial in Neotropical forests.
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- Amada, K., et al.
(författare)
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Discovery of SiO Masers in the "Water Fountain" Source IRAS 16552-3050
- 2022
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 1538-3881 .- 0004-6256. ; 163:2
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we report new detections of SiO v = 1 and v = 2 J = 1 -> 0 masers in the "water fountain" source IRAS 16552-3050, which was observed with the Nobeyama 45 m telescope during 2021 March-April. Water fountains are evolved stars whose H2O maser spectra trace high-velocity outflows of >100 km s(-1). This is the second known case of SiO masers in a water fountain, after their prototypical source, W 43A. These SiO masers should shed light on the evolutionary status of this category of evolved stars, which are likely to be at the end of the asymptotic giant branch phase, when the star exhibits the most copious stellar mass loss, followed by development of the complicated morphologies of planetary nebulae. The origin of a large (up to 25 km s(-1)) velocity offset of the SiO masers with respect to the systemic velocity derived from the spectrum of CO J = 2 -> 1 line is discussed here.
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| 9. |
- Amada, Kei, et al.
(författare)
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Discovery of SiO masers in the Water Fountain source, IRAS 16552-3050
- 2022
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 18, s. 359-361
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Konferensbidrag (refereegranskat)abstract
- We report new detections of SiO ν = 1 and ν = 2 J = 1 → 0 masers in the water fountain source IRAS 16552-3050, which was observed with the Nobeyama 45 m telescope from March 2021 to April 2023. Water fountains are evolved stars whose H2O maser spectra trace high-velocity outflows of >100 Km s-. This is the second known case of SiO masers in a water fountain, after their prototypical source, W 43A. The line-of-sight velocity of the SiO masers are blue-shifted by ∼25 km s-1 from the systemic velocity. This velocity offset imply that the SiO masers are associated with nozzle structure formed by a jet penetrating the circumstellar envelope, and that new gas blobs of the jet erupted recently. Thus, the SiO masers imply this star to be in a new evolutionary stage.
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