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- Bergfors, Elisabet, 1945, et al.
(författare)
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Patch testing children with aluminium chloride hexahydrate in petrolatum: A review and a recommendation
- 2019
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Ingår i: Contact Dermatitis. - : WILEY. - 0105-1873 .- 1600-0536. ; 81:2, s. 81-88
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Forskningsöversikt (refereegranskat)abstract
- Background: According to studies on adults, patch testing with aluminium chloride hexahydrate 2% pet. is insufficient to detect aluminium allergy, and a 10% preparation is recommended. Other studies suggest that a 2% preparation is sufficient for testing children. Objectives: To review three previously published Swedish studies on patch testing children with aluminium chloride hexahydrate 2% pet. Patients/Methods: Altogether, 601 children with persistent itching subcutaneous nodules (granulomas) induced by aluminium-adsorbed vaccines were patch tested with aluminium chloride hexahydrate 2% pet. and metallic aluminium in (a) a pertussis vaccine trial, (b) clinical practice, and (ca) prospective study. Results: Overall, 459 children had positive reactions to the 2% pet. preparation. Another 10 reacted positively only to metallic aluminium. An extreme positive reaction (+++) was seen in 65% of children aged 1 to 2 years as compared with 22% of children aged 7 years. From 8 years onwards, extreme positive reactions were scarce. Conclusions: Aluminium chloride hexahydrate 2% pet. is sufficient to trace aluminium allergy in children. Small children are at risk of extreme reactions. We thus suggest that aluminium chloride hexahydrate 10% pet. should not be used routinely in children before the age of 7 to 8 years.
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| 3. |
- Gente-Lidholm, Anette, et al.
(författare)
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Comparison of reactivity to a metallic disc and 2% aluminium salt in 366 children, and reproducibility over time for 241 young adults with childhood vaccine-related aluminium contact allergy
- 2018
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 79:1, s. 26-30
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Tidskriftsartikel (refereegranskat)abstract
- Background: An aluminium hydroxide-adsorbed pertussis toxoid vaccine was studied in 76 000 children in the 1990s in Gothenburg, Sweden. Long-lasting itchy subcutaneous nodules at the vaccination site were seen in 745 participants. Of 495 children with itchy nodules who were patch tested for aluminium allergy, 377 were positive. In 2007-2008, 241 of the positive children were retested. Only in one third were earlier positive results reproduced. Objectives: To further describe patch test reactions to different aluminium compounds in children with vaccine-induced aluminium allergy. Patients/Methods: Positive patch test results for metallic aluminium (empty Finn Chamber) and aluminium chloride hexahydrate 2% petrolatum (pet.) were analysed in 366 children with vaccine-induced persistent itching nodules tested in 1998-2002. Of those, 241 were tested a second time (2007-2008), and the patch test results of the two aluminium preparations were analysed. Results: Patch testing with aluminium chloride hexahydrate 2% pet. is a more sensitive way to diagnose aluminium contact allergy than patch testing with metallic aluminium. A general decrease in the strength of reactions to both aluminium preparations in 241 children tested twice was observed. Conclusions: Aluminium contact allergy can be diagnosed by patch testing without using metallic aluminium.
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| 4. |
- Inerot, Annica, 1949
(författare)
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Lymfom i huden
- 2018
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Ingår i: Svensk Geriatrik. ; :3, s. 12-17
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Beskrivning och handläggning av personer med misstänkt hudlymfom. Artikeln är riktad till kollegor inom geriatrik och primärvård.
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| 5. |
- Inerot, Annica, 1949, et al.
(författare)
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Unusual presentation and progression of CD30 positive anaplastic large cell lymphoma
- 2015
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Ingår i: In a memory stick, given to all attendeces of this conference.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction and Objectives: Unexpected pathology in a skin lesion on one finger growing during one year, preliminary dermatology diagnosis were among others mycobacterium marinum and leishmaniasis. Materials and methods: A 69 year old male was referred to our dermatology clinic because of a slowly growing mass on one of his fingers. He was otherwise healthy. He has lived in Sweden for many years, but was born in southwest Asia, last visit there was in 2012. He had an aquarium at home. Results: At first visit he had a big mass on his left forth finger but no other skin lesions and his general health was good. The preliminary dermatology diagnosis was mycobacterium marinum infection and he was put on antibiotics and a skin biopsy was taken. Three weeks later there were no signs of improvement. A second diagnosis was considered, leishmaniasis. Histopathology showed normal epidermis. In the dermis there was very dense pleomorphic large cell infiltrates with blastlike morphology. Immunohistochemistry revealed these cells to be Tlymphocytes with CD30 +, CD2 +, CD3 +, CD4 +, CD5 +. ALK and EMA were negative as well as test for Mycobacteria and leishmaniasis. Radiation therapy was started. He received 40 Gy with good regression of the tumour mass. Only few weeks later numerous skin tumours developed over the body, mostly arms and legs. Methotrexate was given, 15-20 mg per week, initially a tendency to response but after 6 months several tumours were dramatically enlarged with ulcerations progressing into oozing, eruptive and bad smelling wounds. General health was still good but he suffered from skin tumor pain. He was hospitalized for further evaluation and to alleviate the pain. Blood test now showed some anemia, but no other significant alterations. CTscan showed enlarged lymph nodes in the groin area, but not accessible for punction or excision. In one of the nose cavities a tumour mass gave him problems with nasal congestion. Tissue sample from this nasal tumor showed high malignant Tcell lymphoma. Treatment with CHOP was given for six sessions during 2 months. He had a complication with septicemia after the first session but could continue the treatment and already after the third session the skin tumours started to regress. After completion of the CHOP a new CTscan revealed also regress of the lymph nodes in the groin, from 18 to 11 mm and a total regress of the mass in the nose cavity. The patient is at home with his family and will have future checkups in the hospital. Conclusion: Anaplastic large cell lymphoma (CD30+) is considered indolent and sometimes selfhealing. This case illustrates both an unusual presenting symptom and shortly thereafter widespread tumours, not selfhealing and without response to methotrexate. With help from colleagues in haematology the patient got treatment with CHOP with good response. Follow up time is only 4 months.
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| 6. |
- Nyman, Gunnar, 1954, et al.
(författare)
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Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis
- 2019
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 81:2, s. 110-116
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Tidskriftsartikel (refereegranskat)abstract
- Background: Beeswax, both white and yellow, has many uses, such as in lip balm. This material can cause contact allergy, although not many cases have been described. Methods: Ninety-five patients with contact cheilitis, facial eczema or a suspicion of contact allergy to beeswax were patch tested with yellow and white beeswax and with propolis, in addition to the Swedish baseline series. Patients who reacted positively to beeswax were additionally tested with caffeic acid, and two derivatives thereof that are believed to be important haptens in propolis. Results: Seventeen patients had positive reactions to beeswax. Fourteen of these patients had been tested with both yellow and white beeswax. Among those 14, eight had positive reactions to both types of wax, five only to yellow wax, and one only to white wax. Of the 10 wax-positive patients tested with caffeic acid derivatives, three reacted positively. Fourteen beeswax-positive patients also had positive reactions to propolis. Conclusion: Patch testing cheilitis patients is important, as contact allergy is common. Our suggestion is to patch test, apart from the baseline series and the patient's own products, also with beeswax and propolis. Many beeswax-allergic cheilitis patients would not have been diagnosed with a relevant contact allergy if only the Swedish baseline series had been used.
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