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Birth order and chi...
Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies
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- Cardwell, Chris R (author)
- Queens University Belfast
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- Stene, Lars C (author)
- Norwegian Institute Public Health
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- Joner, Geir (author)
- University of Oslo
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- Bulsara, Max K (author)
- University of Western Australia
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- Cinek, Ondrej (author)
- Charles University Prague
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- Rosenbauer, Joachim (author)
- University of Dusseldorf
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- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Svensson, Jannet (author)
- Glostrup University Hospital
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- Goldacre, Michael J (author)
- University of Oxford
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- Waldhoer, Thomas (author)
- Medical University of Vienna
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- Jarosz-Chobot, Przemyslawa (author)
- Medical University of Silesia
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- Gimeno, Suely G A (author)
- University Fed Sao Paulo
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- Chuang, Lee-Ming (author)
- National Taiwan University Hospital
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- Roberts, Christine L (author)
- University of Sydney
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- Parslow, Roger C (author)
- University of Leeds
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- Wadsworth, Emma J K (author)
- Cardiff University
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- Chetwynd, Amanda (author)
- University of Lancaster
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- Brigis, Girts (author)
- Riga Stradins University
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- Urbonaite, Brone (author)
- Kaunas University Medical
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- Sipetic, Sandra (author)
- University of Belgrade
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- Schober, Edith (author)
- Medical University of Vienna
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- Devoti, Gabriele (author)
- University of Lecce
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- Ionescu-Tirgoviste, Constantin (author)
- N Paulescu Institute Diabet, Nutr and Metab Disease Clin
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- de Beaufort, Carine E (author)
- Pediat Clin, Luxembourg
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- Stoyanov, Denka (author)
- Childrens Diabet Centre, Sofia
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- Buschard, Karsten (author)
- Rigshosp, Copenhagen
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- Radon, Katja (author)
- Hospital LMU Munich
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- Glatthaar, Christopher (author)
- Sir Charles Gairdner Hospital
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- Patterson, Chris C (author)
- Centre for Public Health, Queen’s University Belfast, Belfast, UK
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(creator_code:org_t)
- 2010-12-10
- 2011
- English.
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In: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. - : OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND. - 0300-5771 .- 1464-3685. ; 40:2, s. 363-374
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies. Methods Relevant studies published before January 2010 were identified from MEDLINE, Web of Science and EMBASE. Authors of studies provided individual patient data or conducted pre-specified analyses. Meta-analysis techniques were used to derive combined odds ratios (ORs), before and after adjustment for confounders, and investigate heterogeneity. Results Data were available for 6 cohort and 25 case-control studies, including 11 955 cases of type 1 diabetes. Overall, there was no evidence of an association prior to adjustment for confounders. After adjustment for maternal age at birth and other confounders, a reduction in the risk of diabetes in second- or later born children became apparent [fully adjusted OR = 0.90 95% confidence interval (CI) 0.83-0.98; P = 0.02] but this association varied markedly between studies (I-2 = 67%). An a priori subgroup analysis showed that the association was stronger and more consistent in children andlt; 5 years of age (n = 25 studies, maternal age adjusted OR = 0.84 95% CI 0.75, 0.93; I-2 = 23%). Conclusion Although the association varied between studies, there was some evidence of a lower risk of childhood onset type 1 diabetes with increasing birth order, particularly in children aged andlt; 5 years. This finding could reflect increased exposure to infections in early life in later born children.
Keyword
- Diabetes mellitus
- type 1
- epidemiology
- birth order
- meta-analysis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cardwell, Chris ...
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Stene, Lars C
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Joner, Geir
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Bulsara, Max K
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Cinek, Ondrej
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Rosenbauer, Joac ...
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show more...
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Ludvigsson, John ...
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Svensson, Jannet
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Goldacre, Michae ...
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Waldhoer, Thomas
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Jarosz-Chobot, P ...
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Gimeno, Suely G ...
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Chuang, Lee-Ming
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Roberts, Christi ...
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Parslow, Roger C
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Wadsworth, Emma ...
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Chetwynd, Amanda
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Brigis, Girts
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Urbonaite, Brone
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Sipetic, Sandra
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Schober, Edith
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Devoti, Gabriele
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Ionescu-Tirgovis ...
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de Beaufort, Car ...
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Stoyanov, Denka
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Buschard, Karste ...
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Radon, Katja
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Glatthaar, Chris ...
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Patterson, Chris ...
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INTERNATIONAL JO ...
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Linköping University