| 1. |
- Islam, Md Mafijul, et al.
(författare)
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Towards benchmarking of functional safety in the automotive industry
- 2013
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Ingår i: Lecture Notes in Computr Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 9783642387883 ; , s. 111-125
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Konferensbidrag (refereegranskat)abstract
- Functional safety is becoming increasingly important in the automotive industry to deal with the growing reliance on the electrical and/or electronic (E/E) systems and the associated complexities. The introduction of ISO 26262, a new standard for functional safety in road vehicles, has made it even more important to adopt a systematic approach of evaluating functional safety. However, standard assessment methods of benchmarking functional safety of automotive systems are not available as of today. This is where the BeSafe (Benchmarking of Functional Safety) project comes into the picture. BeSafe project aims to lay the foundation for benchmarking functional safety of automotive E/E systems. In this paper, we present a brief overview of the project along with the benchmark targets that we have identified as relevant for the automotive industry, assuming three abstraction layers (model, software, hardware). We then define and discuss a set of benchmark measures. Next, we propose a benchmark framework encompassing fault/error models, methods and the required tool support. This paper primarily focuses on functional safety benchmarking from the Safety Element out of Context (SEooC) viewpoint. Finally, we present some preliminary results and highlight potential future works.
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| 2. |
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| 3. |
- Johansson, Henrik, et al.
(författare)
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Targeted resequencing of candidate genes using Selector Probes
- 2011
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 39:2, s. e8-
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Tidskriftsartikel (refereegranskat)abstract
- Targeted genome enrichment is a powerful tool for making use of the massive throughput of novel DNA-sequencing instruments. We herein present a simple and scalable protocol for multiplex amplification of target regions based on the Selector technique. The updated version exhibits improved coverage and compatibility with next-generation-sequencing (NGS) library-construction procedures for shotgun sequencing with NGS platforms. To demonstrate the performance of the technique, all 501 exons from 28 genes frequently involved in cancer were enriched for and sequenced in specimens derived from cell lines and tumor biopsies. DNA from both fresh frozen and formalin-fixed paraffin-embedded biopsies were analyzed and 94 specificity and 98 coverage of the targeted region was achieved. Reproducibility between replicates was high (R 2=0, 98) and readily enabled detection of copy-number variations. The procedure can be carried out in <24 h and does not require any dedicated instrumentation.
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| 4. |
- Planck, Maria, et al.
(författare)
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Genomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to EGFR and KRAS Mutation Status
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:10, s. e78614-
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: In lung adenocarcinoma, the mutational spectrum is dominated by EGFR and KRAS mutations. Improved knowledge about genomic and transcriptional alterations in and between mutation-defined subgroups may identify genes involved in disease development or progression. Methods: Genomic profiles from 457 adenocarcinomas, including 113 EGFR-mutated, 134 KRAS-mutated and 210 EGFR and KRAS-wild type tumors (EGFRwt/KRASwt), and gene expression profiles from 914 adenocarcinomas, including 309 EGFR-mutated, 192 KRAS-mutated, and 413 EGFRwt/KRASwt tumors, were assembled from different repositories. Genomic and transcriptional differences between the three mutational groups were analyzed by both supervised and unsupervised methods. Results: EGFR-mutated adenocarcinomas displayed a larger number of copy number alterations and recurrent amplifications, a higher fraction of total loss-of-heterozygosity, higher genomic complexity, and a more distinct expression pattern than EGFR-wild type adenocarcinomas. Several of these differences were also consistent when the three mutational groups were stratified by stage, gender and smoking status. Specific copy number alterations were associated with mutation status, predominantly including regions of gain with the highest frequency in EGFR-mutated tumors. Differential regions included both large and small regions of gain on 1p, 5q34-q35.3, 7p, 7q11.21, 12p12.1, 16p, and 21q, and losses on 6q16.3-q21, 8p, and 9p, with 20-40% frequency differences between the mutational groups. Supervised gene expression analyses identified 96 consistently differentially expressed genes between the mutational groups, and together with unsupervised analyses these analyses highlighted the difficulty in broadly resolving the three mutational groups into distinct transcriptional entities. Conclusions: We provide a comprehensive overview of the genomic and transcriptional landscape in lung adenocarcinoma stratified by EGFR and KRAS mutations. Our analyses suggest that the overall genomic and transcriptional landscape of lung adenocarcinoma is affected, but only to a minor extent, by EGFR and KRAS mutation status.
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| 5. |
- Staaf, Johan, et al.
(författare)
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Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma
- 2013
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 132:9, s. 2020-2031
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Tidskriftsartikel (refereegranskat)abstract
- Lung cancer is the worldwide leading cause of death from cancer and has been shown to be a heterogeneous disease at the genomic level. To delineate the genomic landscape of copy number alterations, amplifications, loss-of-heterozygosity (LOH), tumor ploidy and copy-neutral allelic imbalance in lung cancer, microarray-based genomic profiles from 2,141 tumors and cell lines including adenocarcinomas (AC, n = 1,206), squamous cell carcinomas (SqCC, n = 467), large cell carcinomas (n = 37) and small cell lung carcinomas (SCLC, n = 88) were assembled from different repositories. Copy number alteration differences between lung cancer histologies were confirmed in 285 unrelated tumors analyzed by BAC array comparative genomic hybridization. Tumor ploidy patterns were validated by DNA flow cytometry analysis of 129 unrelated cases. Eighty-nine recurrent copy number alterations (55 gains, 34 losses) were identified harboring genes with gene expression putatively driven by gene dosage through integration with gene expression data for 496 cases. Thirteen and 26 of identified regions discriminated AC/SqCC and AC/SqCC/SCLC, respectively, while 48 regions harbored recurrent (n > 15) high-level amplifications comprising established and putative oncogenes, differing in frequency and coamplification patterns between histologies. Lung cancer histologies displayed differences in patterns/frequency of copy number alterations, genomic architecture, LOH, copy-neutral allelic imbalance and tumor ploidy, with AC generally displaying less copy number alterations and allelic imbalance. Moreover, a strong association was demonstrated between different types of copy number alterations and allelic imbalances with tumor aneuploidy. In summary, these analyses provide a comprehensive overview of the landscape of genomic alterations in lung cancer, highlighting differences but also similarities between subgroups of the disease.
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| 6. |
- Adler, Jan-Olof, et al.
(författare)
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The upgraded photon tagging facility at the MAX IV Laboratory
- 2013
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 715, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- A description is given of the upgraded photon tagging facility at the MAX IV Laboratory. Two magnetic spectrometers are used to momentum analyze post-bremsstrahlung electrons. The tagged photon range extends from 10 to 180 MeV with an energy resolution of about 300 keV. The system has been operated at rates up to 4 x 10(6) photons s(-1) MeV (-1). Different diagnostic tools are described as well as the experimental program.
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| 7. |
- Anderud, Jonas, et al.
(författare)
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Guided bone augmentation using a ceramic space-maintaining device
- 2014
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Ingår i: Oral surgery, oral medicine, oral pathology and oral radiology. - : Elsevier. - 2212-4403 .- 2212-4411. ; 118:5, s. 532-538
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Tidskriftsartikel (refereegranskat)abstract
- Objective. The purpose of this study was to evaluate 3-dimensionally whether vertical bone augmentation can be achieved using a hollow hydroxyapatite space-maintaining device in a rabbit calvarial model. Furthermore, different inner surface topographies, different permeabilities, and different porosities of the ceramic were tested to determine the optimal conditions for bone regeneration.
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| 8. |
- Björkman, Mats P., et al.
(författare)
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Nitrate dry deposition in svalbard
- 2013
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Ingår i: Tellus. Series B, Chemical and physical meteorology. - : Stockholm University Press. - 0280-6509 .- 1600-0889. ; 65, s. 19071-
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Tidskriftsartikel (refereegranskat)abstract
- Arctic regions are generally nutrient limited, receiving an extensive part of their bio-available nitrogen from the deposition of atmospheric reactive nitrogen. Reactive nitrogen oxides, as nitric acid (HNO3) and nitrate aerosols (p-NO3), can either be washed out from the atmosphere by precipitation or dry deposited, dissolving to nitrate (NO3-). During winter, NO3- is accumulated in the snowpack and released as a pulse during spring melt. Quantification of NO3- deposition is essential to assess impacts on Arctic terrestrial ecology and for ice core interpretations. However, the individual importance of wet and dry deposition is poorly quantified in the high Arctic regions where in-situ measurements are demanding. In this study, three different methods are employed to quantify NO3- dry deposition around the atmospheric and ecosystem monitoring site, Ny-Alesund, Svalbard, for the winter season (September 2009 to May 2010): (1) A snow tray sampling approach indicates a dry deposition of -10.27 +/- 3.84 mg m(-2) (+/- S.E.); (2) A glacial sampling approach yielded somewhat higher values -30.68 +/- 12.00 mg m(-2); and (3) Dry deposition was also modelled for HNO3 and p-NO3 using atmospheric concentrations and stability observations, resulting in a total combined nitrate dry deposition of -10.76 +/- 1.26 mg m(-2). The model indicates that deposition primarily occurs via HNO3 with only a minor contribution by p-NO3. Modelled median deposition velocities largely explain this difference: 0.63 cm s(-1) for HNO3 while p-NO3 was 0.0025 and 0.16 cm s(-1) for particle sizes 0.7 and 7 mm, respectively. Overall, the three methods are within two standard errors agreement, attributing an average 14% (total range of 2-44%) of the total nitrate deposition to dry deposition. Dry deposition events were identified in association with elevated atmospheric concentrations, corroborating recent studies that identified episodes of rapid pollution transport and deposition to the Arctic.
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| 9. |
- Cheraghchi, M., et al.
(författare)
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Approximating Linear Threshold Predicates
- 2010
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Ingår i: Lecture Notes in Computer Science. 13th International Workshop on Approximation Algorithms for Combinatorial Optimization Problems, APPROX 2010 and 14th International Workshop on Randomization and Computation, RANDOM 2010, Barcelona, 1-3 September 2010. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 0302-9743 .- 1611-3349. - 9783642153686 ; 6302, s. 110-123
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Konferensbidrag (refereegranskat)abstract
- We study constraint satisfaction problems on the domain {-1,1}, where the given constraints are homogeneous linear threshold predicates. That is, predicates of the form sgn(w1 x1+⋯+wn x n ) for some positive integer weights w 1, ..., w n . Despite their simplicity, current techniques fall short of providing a classification of these predicates in terms of approximability. In fact, it is not easy to guess whether there exists a homogeneous linear threshold predicate that is approximation resistant or not. The focus of this paper is to identify and study the approximation curve of a class of threshold predicates that allow for non-trivial approximation. Arguably the simplest such predicate is the majority predicate sgn(x 1+⋯+xn ), for which we obtain an almost complete understanding of the asymptotic approximation curve, assuming the Unique Games Conjecture. Our techniques extend to a more general class of "majority-like" predicates and we obtain parallel results for them. In order to classify these predicates, we introduce the notion of Chow-robustness that might be of independent interest.
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| 10. |
- Cheraghchi, M., et al.
(författare)
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Approximating linear threshold predicates
- 2012
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Ingår i: ACM Transactions on Computation Theory. - : Association for Computing Machinery (ACM). - 1942-3454 .- 1942-3462. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- We study constraint satisfaction problems on the domain {-1, 1}, where the given constraints are homogeneous linear threshold predicates, that is, predicates of the form sgn(w 1 x 1 + · · · + w n x n ) for some positive integer weights w 1 , . . . , w n . Despite their simplicity, current techniques fall short of providing a classification of these predicates in terms of approximability. In fact, it is not easy to guess whether there exists a homogeneous linear threshold predicate that is approximation resistant or not. The focus of this article is to identify and study the approximation curve of a class of threshold predicates that allow for nontrivial approximation. Arguably the simplest such predicate is the majority predicate sgn(x 1 + · · · + x n ), for which we obtain an almost complete understanding of the asymptotic approximation curve, assuming the Unique Games Conjecture. Our techniques extend to a more general class of "majority-like" predicates and we obtain parallel results for them. In order to classify these predicates, we introduce the notion of Chow-robustness that might be of independent interest.
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