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| 2. |
- Klug, Stefanie J, et al.
(författare)
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TP53 codon 72 polymorphism and cervical cancer : a pooled analysis of individual data from 49 studies
- 2009
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Ingår i: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 10:8, s. 772-784
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cervical cancer is caused primarily by human papillomaviruses (HPV). The polymorphism rs1042522 at codon 72 of the TP53 tumour-suppressor gene has been investigated as a genetic cofactor. More than 80 studies were done between 1998 and 2006, after it was initially reported that women who are homozygous for the arginine allele had a risk for cervical cancer seven times higher than women who were heterozygous for the allele. However, results have been inconsistent. Here we analyse pooled data from 49 studies to determine whether there is an association between TP53 codon 72 polymorphism and cervical cancer. METHODS: Individual data on 7946 cases and 7888 controls from 49 different studies worldwide were reanalysed. Odds ratios (OR) were estimated using logistic regression, stratifying by study and ethnic origin. Subgroup analyses were done for infection with HPV, ethnic origin, Hardy-Weinberg equilibrium, study quality, and the material used to determine TP53 genotype. FINDINGS: The pooled estimates (OR) for invasive cervical cancer were 1.22 (95% CI 1.08-1.39) for arginine homozygotes compared with heterozygotes, and 1.13 (0.94-1.35) for arginine homozygotes versus proline homozygotes. Subgroup analyses showed significant excess risks only in studies where controls were not in Hardy-Weinberg equilibrium (1.71 [1.21-2.42] for arginine homozygotes compared with heterozygotes), in non-epidemiological studies (1.35 [1.15-1.58] for arginine homozygotes compared with heterozygotes), and in studies where TP53 genotype was determined from tumour tissue (1.39 [1.13-1.73] for arginine homozygotes compared with heterozygotes). Null results were noted in studies with sound epidemiological design and conduct (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes), and studies in which TP53 genotype was determined from white blood cells (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes). INTERPRETATION: Subgroup analyses indicated that excess risks were most likely not due to clinical or biological factors, but to errors in study methods. No association was found between cervical cancer and TP53 codon 72 polymorphism when the analysis was restricted to methodologically sound studies.
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| 3. |
- Ideguchi, E., et al.
(författare)
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Study of high-spin states in 48Ca region induced by secondary fusion reactions
- 2005
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Konferensbidrag (refereegranskat)abstract
- A new method of in-beam gamma-ray spectroscopy induced by secondary fusion reactions, 37P+9Be and 46Ar+9Be is presented. Low-energy secondary beams of 37P and 46Ar ions of ∼5 MeV/A were developed in order to induce fusion evaporation reactions. Excited states of nuclei in the vicinity of 48Ca, 49-52Ti and 46Ca, were studied by the method as well as β decay of the secondary beam 46Ar. Gamma-gamma coincidence and excitation function analysis were performed to study high-spin states of Ti isotopes.
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| 4. |
- Ideguchi, E, et al.
(författare)
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Study of high-spin states in the Ca-48 region by using secondary fusion reactions
- 2005
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 25, s. 429-430
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Tidskriftsartikel (refereegranskat)abstract
- An in-beam gamma-ray spectroscopy study, following a fusion reaction induced by a neutronrich secondary beam, Ar-46 + Be-9, is presented. A low-energy secondary beam of Ar-46 at similar to 5 MeV/A was developed in order to induce fusion reactions. Gamma-gamma coincidence and excitation function analysis was performed to study high-spin states in the vicinity of Ca-48, Ti49-52.
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| 5. |
- Kobayashi, M., et al.
(författare)
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Hybridization between the conduction band and 3d orbitals in the oxide-based diluted magnetic semiconductor In2-xVxO3
- 2009
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 79:20, s. 205203-
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Tidskriftsartikel (refereegranskat)abstract
- The electronic structure of In2-xVxO3 (x=0.08) has been investigated by photoemission spectroscopy and x-ray absorption spectroscopy (XAS). The V 2p core-level photoemission and XAS spectra revealed that the V ion is in the trivalent state, which is the same valence state as that of In in In2O3. The V 3d partial density of states obtained by the resonant photoemission technique showed a sharp peak above the O 2p band. While the O 1s XAS spectrum of In2-xVxO3 was similar to that of In2O3, there were differences in the In 3p and 3d XAS spectra between the V-doped and pure In2O3. The observations give clear evidence for hybridization between the In-derived conduction band and the V 3d orbitals in In2-xVxO3.
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