| 1. |
- Harcourt, R., et al.
(författare)
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Animal-borne telemetry: An integral component of the ocean observing toolkit
- 2019
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Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745. ; 6:JUN
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Tidskriftsartikel (refereegranskat)abstract
- Animal telemetry is a powerful tool for observing marine animals and the physical environments that they inhabit, from coastal and continental shelf ecosystems to polar seas and open oceans. Satellite-linked biologgers and networks of acoustic receivers allow animals to be reliably monitored over scales of tens of meters to thousands of kilometers, giving insight into their habitat use, home range size, the phenology of migratory patterns and the biotic and abiotic factors that drive their distributions. Furthermore, physical environmental variables can be collected using animals as autonomous sampling platforms, increasing spatial and temporal coverage of global oceanographic observation systems. The use of animal telemetry, therefore, has the capacity to provide measures from a suite of essential ocean variables (EOVs) for improved monitoring of Earth's oceans. Here we outline the design features of animal telemetry systems, describe current applications and their benefits and challenges, and discuss future directions. We describe new analytical techniques that improve our ability to not only quantify animal movements but to also provide a powerful framework for comparative studies across taxa. We discuss the application of animal telemetry and its capacity to collect biotic and abiotic data, how the data collected can be incorporated into ocean observing systems, and the role these data can play in improved ocean management. © 2019 Harcourt, Sequeira, Zhang, Roquet, Komatsu, Heupel, McMahon, Whoriskey, Meekan, Carroll, Brodie, Simpfendorfer, Hindell, Jonsen, Costa, Block, Muelbert, Woodward, Weise, Aarestrup, Biuw, Boehme, Bograd, Cazau, Charrassin, Cooke, Cowley, de Bruyn, Jeanniard du Dot, Duarte, Eguíluz, Ferreira, Fernández-Gracia, Goetz, Goto, Guinet, Hammill, Hays, Hazen, Hückstädt, Huveneers, Iverson, Jaaman, Kittiwattanawong, Kovacs, Lydersen, Moltmann, Naruoka, Phillips, Picard, Queiroz, Reverdin, Sato, Sims, Thorstad, Thums, Treasure, Trites, Williams, Yonehara and Fedak.
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| 2. |
- McLoughlin, M. R., et al.
(författare)
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TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
- 2019
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 116:23, s. 11408-11417
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Tidskriftsartikel (refereegranskat)abstract
- Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-driven antioxidant systems form an integrated network that combats potentially carcinogenic oxidative damage yet also protects cancer cells from oxidative death. Here we show that although unchallenged wild-type (WT), TrxR1-null, or Gsr-null mouse livers exhibited similarly low DNA damage indices, these were 100-fold higher in unchallenged TrxR1/Gsr-double-null livers. Notwithstanding, spontaneous cancer rates remained surprisingly low in TrxR1/Gsr-null livers. All genotypes, including TrxR1/Gsr-null, were susceptible to N-diethylnitrosamine (DEN)-induced liver cancer, indicating that loss of these antioxidant systems did not prevent cancer cell survival. Interestingly, however, following DEN treatment, TrxR1-null livers developed threefold fewer tumors compared with WT livers. Disruption of TrxR1 in a marked subset of DEN-initiated cancer cells had no effect on their subsequent contributions to tumors, suggesting that TrxR1-disruption does not affect cancer progression under normal care, but does decrease the frequency of DEN-induced cancer initiation. Consistent with this idea, TrxR1-null livers showed altered basal and DEN-exposed metabolomic profiles compared with WT livers. To examine how oxidative stress influenced cancer progression, we compared DEN-induced cancer malignancy under chronically low oxidative stress (TrxR1-null, standard care) vs. elevated oxidative stress (TrxR1/Gsr-null livers, standard care or phenobarbital-exposed TrxR1-null livers). In both cases, elevated oxidative stress was correlated with significantly increased malignancy. Finally, although TrxR1-null and TrxR1/Gsr-null livers showed strong Nrf2 activity in noncancerous hepatocytes, there was no correlation between malignancy and Nrf2 expression within tumors across genotypes. We conclude that TrxR1, Gsr, Nrf2, and oxidative stress are major determinants of liver cancer but in a complex, context-dependent manner.
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| 4. |
- McCracken, R. G., et al.
(författare)
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Origin of the active drumlin field at Mulajokull, Iceland: New insights from till shear and consolidation patterns
- 2016
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791. ; 148, s. 243-260
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Tidskriftsartikel (refereegranskat)abstract
- Stratigraphic and morphologic data previously collected from the forefleld of Millajokull, Iceland, suggest that its recent surge cycles are responsible for the formation of drumlins there and that their relief reflects both deposition on drumlins and erosion between them. We have tested these ideas and aspects of leading models of drumlin formation by studying past patterns of bed deformation and effective stress in basal tills of the glacier's forefield. Patterns of till strain indicated by the anisotropy of magnetic susceptibility (AMS) of similar to 2300 intact till samples indicate that till was deposited during shear deformation, with shearing azimuths and planes that conform to the drumlin morphology. Thus, till deposition occurred as drumlins grew, in agreement with LiDAR data indicating that the degree of aggradation of the glacier forefleld is largest in areas subjected to the most surges. Previously described unconformities on the drumlin flanks, however, indicate that drumlin relief at Mulajokull has resulted, in part, from erosion. Given that the last surge deposited a till layer both on and between drumlins, a reasonable hypothesis is that erosion between drumlins occurred during normal (quiescent) flow of the glacier between surges. Densities of till samples, analyzed in conjunction with laboratory consolidation tests, indicate that effective stresses on the bed during such periods were on the order of 100 kPa larger between drumlins than within them, an observation consistent with subglacial channels at low water pressure occupying interdrumlin areas. Transport of sediment by turbulent flow in these channels or high effective stress adjacent to them causing enhanced till entrainment in ice or increased depths of bed deformation would promote the sediment flux divergence necessary to erode areas between drumlins. The observation that effective stresses were higher between drumlins than within them is the opposite of that presumed in leading models of drumlin formation. Moreover, the lack of AMS-fabric evidence of longitudinal compression in drumlin tills does not support some models of drumlin formation that invoke negative till-flux gradients in a deforming bed.
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