High throughput separation of bacteria from blood for sepsis diagnostics using extended elasto-inertial microfluidics

• Separation of bacteria from blood for sepsis diagnostics has received substantial interest due to lack of high throughput alternatives. Here, we introduce extended elasto-inertial microfluidics based high throughput (1 mL/min) separation of bacteria from whole blood. We demonstrate separation of E.coli from 1 mL of whole blood in 40 min using a single spiral chip with 90% separation efficiency. This opens up opportunities by aiding for downstream analysis, by reducing the time of sample preparation for sepsis diagnosis.

Ämnesord

NATURVETENSKAP  -- Kemi -- Analytisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Analytical Chemistry (hsv//eng)

Nyckelord

Bacteria

Blood

Elasto-inertial microfluidics

High throughput

Microfluidics

Sepsis

Separation

Inertial microfluidics

Sample preparation

Separation efficiency

Whole blood

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