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Träfflista för sökning "WFRF:(Jacobson S. A.) srt2:(1996-1999)"

Sökning: WFRF:(Jacobson S. A.) > (1996-1999)

  • Resultat 1-7 av 7
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  • Frey, Sharon, et al. (författare)
  • Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine
  • 1999
  • Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 180:6, s. 2018-2022
  • Tidskriftsartikel (refereegranskat)abstract
    • A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.
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  • Jacobson, S G, et al. (författare)
  • Digenic inheritance of a ROM1 gene mutation with a peripherin/RDS or rhodopsin mutation in families with retinitis pigmentosa
  • 1999
  • Ingår i: Digital Journal of Ophthalmology. - 1542-8958. ; 5:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Two families with retinitis pigmentosa showed inheritance of an Arg-16-His ROM1 gene mutation with either an Arg-13-Trp RDS mutation or an Arg-135-Trp RHO mutation. The phenotypes of double and single heterozygotes were determined to examine the hypothesis that digenic inheritance may increase disease expression. In the family with ROM1 and RDS mutations, single heterozygotes were normal but one double heterozygote showed severe RP. Two other double heterozygotes, however, were normal by clinical and retinal function tests. In the family with ROM1 and RHO mutations, single heterozygotes with the RHO mutation all manifested RP, while a single heterozygote for the ROM1 mutation was normal. Disease severity was comparable in double heterozygotes and single heterozygotes HAVING the RHO mutation. We conclude that the Arg-16-His ROM1 gene mutation is non-pathogenic in the single heterozygous state, and there is no consistent evidence of digenic augmentation of pathogenicity in double heterozygotes carrying the Arg-16-His ROM1 mutation with either the benign Arg-13-Trp RDS mutation or the disease-causing Arg-135-Trp RHO mutation.
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  • Gahlin, R, et al. (författare)
  • The effects of compressive stresses on the abrasion of diamond coatings
  • 1996
  • Ingår i: WEAR. - : ELSEVIER SCIENCE SA LAUSANNE. - 0043-1648. ; 196:1-2, s. 226-233
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The effects of high biaxial compressive stresses on the abrasion of diamond coatings by diamond particles were evaluated using an atomic force microscope (AFM). The specimens subjected to testing were diamond coatings deposited on cemented carbide substra
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  • Resultat 1-7 av 7

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