| 1. |
- Andersson, Eva, et al.
(författare)
-
Evaluation of OAE-recording as a complementary test method for adults with moderate to profound mental retardation
- 2000
-
Ingår i: Scandinavian Audiology. - : Taylor & Francis. - 0105-0397 .- 1940-2872. ; 29:2, s. 120-126
-
Tidskriftsartikel (refereegranskat)abstract
- The recording of otoacoustic emissions (OAE) was evaluated as a complementary test method for adults with moderate to profound mental retardation (MR). A portable apparatus, ILO 288 Echoport linked to a Compaq LTE 5100 notebook with software ILO 88 V 4.2, was used. Otoscopy and tympanometry were also performed. Criteria for emissions were S/N 3 dB or more and reproducibility 60% or more for at least three frequency-bands. The criteria for partial emissions were the same, but for only one or two frequencies. Two examiners were needed: one to keep the tested person calm and quiet and the other to handle the keyboard. Thirty-eight people with different degrees of MR in connection with other disabilities were included. They had all exhibited incomplete results in a previous hearing screening of more than 1000 adults with MR. Reproducible transiently evoked OAEs (TEOAE) were recorded from II ears (7 people), partial TEOAEs from 6 ears (4 people) and no emissions from 15 ears (10 people). Registration from 24 ears (13 people) could not be evaluated because of too much external and internal noise. Eight people rejected the examination. Only four people showed emissions in both ears. Accordingly, 34 people (89.5%) had to be re-tested or referred for further investigation, 21 of them (55%) because of noisy recordings or no co-operation. It is concluded that the TEOAE-test in its present form cannot fulfil the demands for a functioning test method for this population. In single cases, however, TEOAE-recording can complement other audiological tests.
|
|
| 2. |
|
|
| 3. |
- Jacobsson, Eva, 1957-
(författare)
-
Till eget gagn - till andras nytta : en komparativ studie av allmännyttigt byggande i Stockholm fram till år 1940
- 2000
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation consists of three main parts. The first part describes the theoretical background and gives further details about the different approaches to the housing and construction markets that have been brought forward by various scholars. Five chapters examine three alternative strategies when it came to overcoming the problems of the free market. In this case, it is about the philanthropic and cooperative housing solutions and about the business owners' construction of company-owned housing for their employees. Two comparative chapters conclude this section. The first chapter examines the social structure in various company-owned housing complexes, and cooperatives in Stockholm. An answer of the question on how to proceed was Belizeved to lie in a thorough reform of the housing market. Whereas the earlier chapters deal with the question of reducing the problems through the creation of a different type of housing construction, a municipal construction project where the profit-motives are lessened, the focus now changes. There arose an explicit desire to create other market rules. At the same time, influential politicians sought to develop a large-scale cooperative housing initiative with popular support. The last chapter describes the initial phase of this era, during the 1930s.Key words: the counter-cyclic theory, rent-driven construction, cost-steered construction, freedom-of-choice paradox, boom economies, depression, joint-stock housing companies, directive measures, cooperative-housing-society movement, SKB, HSB, the limited patriarchal system, the modern insurance model, the board and lodgings system, old age insurance, birth control, democratic pride, educational program, directive or general measures, the modern housing question, "cheap-housing politics".
|
|
| 4. |
- Jacobsson, F., et al.
(författare)
-
Safety profile and tolerability of intravenous AR-C69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction
- 2002
-
Ingår i: Clinical Therapeutics. - 0149-2918 .- 1879-114X. ; 24:5, s. 752-765
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Thrombin generation and platelet aggregation in the disrupted atherosclerotic plaque are the major reasons for thrombus formation associated with acute coronary events. AR-C69931MX is a new agent that inhibits adenosine diphosphate-induced platelet aggregation by antagonism of the P2T purinoceptor. Objective: This study assessed the safety profile, tolerability, and plasma concentrations at steady state of intravenous AR-C69931MX in patients with unstable angina pectoris or non-Q-wave myocardial infarction (MI). Methods: This was a Phase II, multicenter, double-blind, randomized, placebo-controlled trial. Patients with unstable angina or non-Q-wave MI were randomized to a 72-hour infusion of AR-C69931MX or placebo as adjunctive therapy to aspirin and low-molecular-weight heparin. Other treatment was at the discretion of the local investigator. Outcomes were assessed at 30 days. Results: Ninety-four patients were randomized and 91 received treatment (45 AR-C69931MX, 46 placebo). Plasma concentrations of AR-C69931MX were within the expected range, there were no signs of accumulation, and interindividual variability in clearance was low. Four patients receiving AR-C69931MX discontinued treatment due to minor bleeding events, and 5 patients receiving placebo discontinued treatment due to other adverse events or deterioration in their condition. No serious bleeding events were seen during treatment. The incidence of =1 episode of minor bleeding was slightly higher in patients receiving AR-C69931MX compared with those receiving placebo (38% vs 26%, respectively). The drug was well tolerated hemodynamically, and there were no significant changes in other laboratory values between groups. Conclusions: As adjunctive therapy to aspirin and low-molecular-weight heparin in patients with unstable angina or non-Q-wave MI, intravenous AR-C69931MX was well tolerated, with no difference in the incidence of serious adverse events compared with placebo.
|
|
| 5. |
|
|
| 6. |
- Jacobsson, Micael, et al.
(författare)
-
Improving structure-based virtual screening by multivariate analysis of scoring data
- 2003
-
Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 46:26, s. 5781-5789
-
Tidskriftsartikel (refereegranskat)abstract
- hree different multivariate statistical methods, PLS discriminant analysis, rule-based methods, and Bayesian classification, have been applied to multidimensional scoring data from four different target proteins: estrogen receptor alpha (ERalpha), matrix metalloprotease 3 (MMP3), factor Xa (fXa), and acetylcholine esterase (AChE). The purpose was to build classifiers able to discriminate between active and inactive compounds, given a structure-based virtual screen. Seven different scoring functions were used to generate the scoring matrices. The classifiers were compared to classical consensus scoring and single scoring functions. The classifiers show a superior performance, with rule-based methods being most effective. The precision of correctly predicting an active compound is about 90% for three of the targets and about 25% for acetylcholine esterase. On the basis of these results, a new two-stage approach is suggested for structure-based virtual screening where limited activity information is available.
|
|
| 7. |
|
|
