| 1. |
- Aliu, E., et al.
(författare)
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Long Term Observations of B2 1215+30 with VERITAS
- 2013
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 779:2
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Tidskriftsartikel (refereegranskat)abstract
- We report on VERITAS observations of the BL Lac object B2 1215+30 between 2008 and 2012. During this period, the source was detected at very high energies (VHEs; E > 100 GeV) by VERITAS with a significance of 8.9s and showed clear variability on timescales larger than months. In 2011, the source was found to be in a relatively bright state and a power-law fit to the differential photon spectrum yields a spectral index of 3.6 +/- 0.4(stat) +/- 0.3(syst) withan integral flux above 200 GeV of (8.0 +/- 0.9(stat) +/- 3.2(syst)) x 10(-12) cm(-2) s(-1). No short term variability could be detected during the bright state in 2011. Multi-wavelength data were obtained contemporaneously with the VERITAS observations in 2011 and cover optical (Super-LOTIS, MDM, Swift/UVOT), X-ray (Swift/XRT), and gamma-ray (Fermi-LAT) frequencies. These were used to construct the spectral energy distribution (SED) of B2 1215+30. A one-zone leptonic model is used to model the blazar emission and the results are compared to those of MAGIC from early 2011 and other VERITAS-detected blazars. The SED can be reproduced well with model parameters typical for VHE-detected BL Lac objects.
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| 2. |
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| 3. |
- Singh, Purnima, et al.
(författare)
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High-spin spectroscopy of I-122
- 2012
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 85:5
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in I-122 have been investigated using the Cd-116(B-11,5n)I-122 reaction at a beam energy of 65 MeV and gamma-ray coincidence events were recorded with the INGA spectrometer. The level scheme of I-122 has been extended up to spin I = 30. Experimental features, such as band-crossing frequencies, aligned angular momenta, signature splitting, and B(M1)/B(E2) ratios have been used for configuration assignments to low-energy band structures. Maximally aligned states involving all eight particles outside the Sn-114 core and states with one particle antialigned have been identified. Cranked Nilsson-Strutinsky calculations have been used to interpret high-spin structures.
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| 4. |
- Harreither, E., et al.
(författare)
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Characterization of a novel cell penetrating peptide derived from human Oct4
- 2014
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Ingår i: Cell Regeneration. - : Springer Science and Business Media LLC. - 2045-9769. ; 3:2, s. 2-3:2
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Tidskriftsartikel (refereegranskat)abstract
- Oct4 is a transcription factor that plays a major role for the preservation of the pluripotent state in embryonic stem cells as well as for efficient reprogramming of somatic cells to induced pluripotent stem cells (iPSC) or other progenitors. Protein-based reprogramming methods mainly rely on the addition of a fused cell penetrating peptide. This study describes that Oct4 inherently carries a protein transduction domain, which can translocate into human and mouse cells.A 16 amino acid peptide representing the third helix of the human Oct4 homeodomain, referred to as Oct4 protein transduction domain (Oct4-PTD), can internalize in mammalian cells upon conjugation to a fluorescence moiety thereby acting as a cell penetrating peptide (CPP). The cellular distribution of Oct4-PTD shows diffuse cytosolic and nuclear staining, whereas penetratin is strictly localized to a punctuate pattern in the cytoplasm. By using a Cre/loxP-based reporter system, we show that this peptide also drives translocation of a functionally active Oct4-PTD-Cre-fusion protein. We further provide evidence for translocation of full length Oct4 into human and mouse cell lines without the addition of any kind of cationic fusion tag. Finally, physico-chemical properties of the novel CPP are characterized, showing that in contrast to penetratin a helical structure of Oct4-PTD is only observed if the FITC label is present on the N-terminus of the peptide.Oct4 is a key transcription factor in stem cell research and cellular reprogramming. Since it has been shown that recombinant Oct4 fused to a cationic fusion tag can drive generation of iPSCs, our finding might contribute to further development of protein-based methods to generate iPSCs.Moreover, our data support the idea that transcription factors might be part of an alternative paracrine signalling pathway, where the proteins are transferred to neighbouring cells thereby actively changing the behaviour of the recipient cell.
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| 5. |
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| 6. |
- Jadhav, S, et al.
(författare)
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Studies on colloidal stability of PVP-coated LSMO nanoparticles for magnetic fluid hyperthermia
- 2013
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Ingår i: New Journal of Chemistry. - : Royal Society of Chemistry. - 1144-0546 .- 1369-9261. ; 37, s. 3121-3130
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Tidskriftsartikel (refereegranskat)abstract
- La0.7Sr0.3MnO3 (LSMO) nanoparticles with a size of ∼23 nm have been prepared by a combustion method and functionalized with polyvinylpyrrolidone (PVP) for their possible application in magnetic fluid hyperthermia (MFH). Uncoated and PVP-coated samples were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, high resolution transmission electron microscopy and vibrating sample magnetometer studies. Magnetic measurements of both coated and uncoated particles reveal the superparamagnetic nature at room temperature. Colloidal stability has been measured in terms of zeta potential. The resulting PVP-coated particles form a stable suspension in phosphate buffer saline (PBS) and double distilled water (DDW) and possess a narrow hydrodynamic size distribution. The induction heating studies of these nanoparticles at different alternating magnetic fields (167.6, 251.4 and 335.2 Oe) were carried out by dispersing nanoparticles in DDW and PBS. These PVP-coated LSMO NPs exhibit a higher specific absorption rate in PBS than in DDW. The results suggest that combustion-synthesized LSMO nanoparticles coated with PVP can be used as potential heating agents in MFH.
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| 7. |
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| 8. |
- Murray, Ewan J, et al.
(författare)
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Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors.
- 2014
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Ingår i: Journal of medicinal chemistry. - : American Chemical Society (ACS). - 1520-4804 .- 0022-2623. ; 57:6, s. 2813-2819
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Tidskriftsartikel (refereegranskat)abstract
- A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as negative allosteric modulators and are exemplified by 3-tetradecanoyltetronic acid 17, which reduced nasal cell colonization and arthritis in a murine infection model.
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