| 1. |
- Gurav, Ranjit, et al.
(författare)
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Production, characterization, and application of biochar for remediation of dyes from textile industry wastewater
- 2023
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Ingår i: Current Developments in Bioengineering and Biotechnology. - : Elsevier BV. ; , s. 231-251
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Dyes are coloring agents widely used in the textile and leather industries. Synthetic dyes are the major contributor to global wastewater exhibiting toxic effects on humans, aquatic organisms, and the environment. The conventional decolorization treatments are less effective due to high dye concentration in wastewater, complex chemical structure, and poor biodegradability. Several strategies like physical, chemical, and biological were reported earlier for dye decolorization. However, the adsorption technique has been extensively considered from economic and ecological standpoints. Biochar, a carbonaceous material generated by pyrolyzing waste biomass has been discussed here to tackle the dye-containing wastewater. As an adsorbent, biochar has gained considerable attention owing to its underlying advantages like larger surface area, high porosity, low production cost, varied surface functional groups, easy surface modifications, exceptional hydrophobicity, and aromaticity. In this chapter, we have discussed approaches for the production, and characterization of the biochar. Furthermore, we have also considered the effect of different physicochemical properties, sorption kinetics, isotherm models, and other key factors affecting the sorption mechanism. In this perspective, an effort has been made in this chapter to explore the probability and practicability of biochar as a sorbent for removal of the textile dyes.
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| 2. |
- Leonard, Hampton L., et al.
(författare)
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The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data
- 2023
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Ingår i: npj Parkinson's Disease. - : Springer Science and Business Media LLC. - 2373-8057. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD.
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| 3. |
- Tannergren, C., et al.
(författare)
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Physiologically based biopharmaceutics modeling of regional and colon absorption in humans
- 2023
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Ingår i: European Journal of Pharmaceutics and Biopharmaceutics. - : Elsevier. - 0939-6411 .- 1873-3441. ; 186, s. 144-159
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Tidskriftsartikel (refereegranskat)abstract
- Colon absorption is a key determinant for successful development of extended release and colon targeted drug products. This is the first systematic evaluation of the ability to predict in vivo regional differences in absorption and the extent of colon absorption in humans using mechanistic physiologically based biopharmaceutics modeling (PBBM). A new dataset, consisting of 19 drugs with a wide range of biopharmaceutics properties and extent of colon absorption in humans, was established. Mechanistic predictions of the extent of absorption and plasma exposure after oral, or jejunal and direct colon administration were performed in GastroPlus and GI-Sim using an a priori approach. Two new colon models developed in GI-Sim, were also evaluated to assess if the prediction performance could be improved. Both GastroPlus and GI-Sim met the pre-defined criteria for accurate predictions of regional and colon absorption for high permeability drugs irrespective of formulation type, while the prediction performance was poor for low permeability drugs. For solutions, the two new GI-Sim colon models improved the colon absorption prediction performance for the low permeability drugs while maintaining the accurate prediction performance for the high permeability drugs. In contrast, the prediction performance decreased for non-solutions using the two new colon models. In conclusion, PBBM can be used with sufficient accuracy to predict regional and colon absorption in humans for high permeability drugs in candidate selection as well as early design and development of extended release or colon targeted drug products. The prediction performance of the current models needs to be improved to allow high accuracy predictions for commercial drug product applications including highly accurate predictions of the entire plasma concentration-time profiles as well as for low permeability drugs.
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