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Long-term SARS-CoV-...
Long-term SARS-CoV-2 surveillance in the wastewater of Stockholm : What lessons can be learned from the Swedish perspective?
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- Perez-Zabaleta, Mariel, 1987- (författare)
- KTH,Resursåtervinning,Industriell bioteknologi,Albanova VinnExcellence Center for Protein Technology, ProNova
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- Archer, Amena (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
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- Khatami, Kasra (författare)
- KTH,Kemiteknik,Albanova VinnExcellence Center for Protein Technology, ProNova,Industriell bioteknologi
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- Jafferali, Mohammed Hakim (författare)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
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- Nandy, Prachi (författare)
- KTH,Kemiteknik
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- Atasoy, Merve, PhD, 1990- (författare)
- KTH,Resursåtervinning
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- Birgersson, Madeleine (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Williams, Cecilia, Professor, 1969- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
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- Cetecioglu, Zeynep, PhD, 1981- (författare)
- KTH,Industriell bioteknologi,Resursåtervinning,Albanova VinnExcellence Center for Protein Technology, ProNova
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 858
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Wastewater-based epidemiology (WBE) can be used to track the spread of SARS-CoV-2 in a population. This study pre-sents the learning outcomes from over two-year long monitoring of SARS-CoV-2 in Stockholm, Sweden. The three main wastewater treatment plants in Stockholm, with a total of six inlets, were monitored from April 2020 until June 2022 (in total 600 samples). This spans five major SARS-CoV-2 waves, where WBE data provided early warning signals for each wave. Further, the measured SARS-CoV-2 content in the wastewater correlated significantly with the level of positive COVID-19 tests (r = 0.86; p << 0.0001) measured by widespread testing of the population. Moreover, as a proof-of-concept, six SARS-CoV-2 variants of concern were monitored using hpPCR assay, demonstrating that var-iants can be traced through wastewater monitoring.During this long-term surveillance, two sampling protocols, two RNA concentration/extraction methods, two calcula-tion approaches, and normalization to the RNA virus Pepper mild mottle virus (PMMoV) were evaluated. In addition, a study of storage conditions was performed, demonstrating that the decay of viral RNA was significantly reduced upon the addition of glycerol to the wastewater before storage at -80 degrees C. Our results provide valuable information that can facilitate the incorporation of WBE as a prediction tool for possible future outbreaks of SARS-CoV-2 and preparations for future pandemics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Severe acute respiratory syndrome coronavirus 2
- (SARS-CoV-2)
- COVID-19
- Wastewater-based epidemiology (WBE)
- Storage conditions
- Sewage surveillance
- hpPCR
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Perez-Zabaleta, ...
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Archer, Amena
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Khatami, Kasra
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Jafferali, Moham ...
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Nandy, Prachi
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Atasoy, Merve, P ...
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Birgersson, Made ...
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Williams, Cecili ...
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Cetecioglu, Zeyn ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Infektionsmedici ...
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Science of the T ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet