| 1. |
- Arking, D. E., et al.
(författare)
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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
- 2014
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 46:8, s. 826-836
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼ 8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. © 2014 Nature America, Inc.
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| 4. |
- Thiele, I., et al.
(författare)
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A community-driven global reconstruction of human metabolism
- 2013
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Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 31:5, s. 419-
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Tidskriftsartikel (refereegranskat)abstract
- Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including similar to 2x more reactions and similar to 1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.
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| 5. |
- Majdi, Saman, et al.
(författare)
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High Performance Temperature Sensors using SC-CVD Diamond Schottky Diodes
- 2012
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Ingår i: Applied Physics Letters. - 0003-6951 .- 1077-3118.
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of new materials for thermal IR detection has been an intensive research area during the recent years. Among the new materials, diamond has the ability to function under high temperature, high power, and high radiation conditions, which enables large performance enhancements to a wide variety of systems and applications, e.g. electric vehicles, space exploration and nuclear energy reactors. In this study, diamond Schottky diodes (with boron concentrations in the range 1×1015 - 3×1016 cm-3) are presented as candidates for IR sensors with an excellent temperature coefficient of resistance (-16 %/K) and noise levels around 1.8×10-14 (V2/Hz).
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| 6. |
- Jamshidi, Asghar, et al.
(författare)
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Growth of GeSnSiC layers for photonic applications
- 2013
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Ingår i: Surface & Coatings Technology. - : Elsevier. - 0257-8972 .- 1879-3347. ; 230, s. 106-110
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Tidskriftsartikel (refereegranskat)abstract
- This work presents epitaxial growth of intrinsic and doped GeSnSiC layers using Ge2H6, SnCl4, CH3SiH3, B2H6, PH3 and Si2H6 deposited at 290-380 degrees C on strain relaxed Ge buffer layer or Si substrate by using reduced pressure chemical vapor deposition (RPCVD) technique. The GeSnSi layers were compressively strained on Ge buffer layer and strain relaxed on Si substrate. It was demonstrated that the quality of epitaxial layers is dependent on the growth parameters and that the Sn content in epi-layers could be tailored by growth temperature. The Sn segregation caused surface roughness which was decreased by introducing Si and Si-C into Ge layer. less thanbrgreater than less thanbrgreater thanThe Sn content in GeSn was carefully determined from the mismatch, both parallel and perpendicular, to the growth direction when the Poisson ratio was calculated for a certain Ge-Sn composition. The X-ray results were excellently consistent with Rutherford Backscattered Spectroscopy (RBS). Strain relaxed GeSn layers were also used as virtual substrate to grow tensile-strained Ge layers. The Ge cap layer had low defect density and smooth surface which makes it a viable candidate material for future photonic applications.
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| 7. |
- Mistry, Nitesh, et al.
(författare)
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Coxsackievirus A24 variant uses aialic acid-containing O-Linked glycoconjugates as cellular receptors on human ocular cells
- 2011
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Ingår i: Journal of Virology. - Baltimore : American Society for Microbiology. - 0022-538X .- 1098-5514. ; 85:21, s. 11283-11290
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Tidskriftsartikel (refereegranskat)abstract
- Coxsackievirus A24 variant (CVA24v) is a main causative agent of acute hemorrhagic conjunctivitis (AHC), which is a highly contagious eye infection. Previously it has been suggested that CVA24v uses sialic acid-containing glycoconjugates as attachment receptors on corneal cells, but the nature of these receptors is poorly described. Here, we set out to characterize and identify the cellular components serving as receptors for CVA24v. Binding and infection experiments using corneal cells treated with deglycosylating enzymes or metabolic inhibitors of de novo glycosylation suggested that the receptor(s) used by CVA24v are constituted by sialylated O-linked glycans that are linked to one or more cell surface proteins but not to lipids. CVA24v bound better to mouse L929 cells overexpressing human P-selectin glycoprotein ligand-1 (PSGL-1) than to mock-transfected cells, suggesting that PSGL-1 is a candidate receptor for CVA24v. Finally, binding competition experiments using a library of mono- and oligosaccharides mimicking known PSGL-1 glycans suggested that CVA24v binds to Neu5Ac alpha 2,3Gal disaccharides (Neu5Ac is N-acetylneuraminic acid). These results provide further insights into the early steps of the CVA24v life cycle.
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| 9. |
- Rafiee, Ali, et al.
(författare)
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Fire and smoke detection using wavelet analysis and disorder characteristics
- 2011
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Ingår i: ICCRD2011 - 2011 3rd International Conference on Computer Research and Development, vol 3, 2011. - 9781612848396 ; , s. 262-265
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Konferensbidrag (refereegranskat)abstract
- Fire and smoke monitoring systems are useful in different industry such as military, social security and economical. The recent methods for fire and smoke detection are used only motion and color characteristics thus many wrong alarms are happening and this is decrease the performance of the systems. This research presents a new method for fire and smoke detection through image processing. In this algorithm all objects in an image is considered and then check them to figure out which objects are smoke and fire. The color, motion and disorder are useful characteristics in fire and smoke detection algorithm. Smoke of fire will blur the whole or part of the images. Thus by processing of the video frames, different objects will detect. Due to evaluate the features of objects, the goal objects (fire and smoke) can be defined easily. Two-dimensional wavelet analysis is used in the presented method. The results of this research present the proposed features that can reduce the wrong alarms and increase the system performances.
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