| 1. |
- Bell, Brian, et al.
(författare)
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Sustainable Bridges – Past and Future. Reflections on a European Project 2003 – 2007
- 2023
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Ingår i: IABSE Congress 2023 New Delhi, Engineering for Sustainable Development. - : International Association for Bridge and Structural Engineering. ; , s. 690-698
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Konferensbidrag (refereegranskat)abstract
- Twenty years ago, in 2003, a European project was started to increase the sustainability of existing railway bridges. This paper summarises what was achieved and looks ahead. Nine Working Packages were organized: (1) Background material; (2) Guidance by stakeholders; (3) Condition Assessment and Inspection Guidelines; (4) Loads, Capacity and Resistance Guidelines; (5) Monitoring Guidelines; (6) Repair and Strengthening Guidelines; (7) Demonstration with Field testing of Bridges; (8) Demonstration on Monitoring on Bridges; and (9) Training and Dissemination.Some of the main results (from 4 Guidelines and 47 Background documents) are highlighted and some experiences, conclusions and thoughts about the future are given. Hidden strengths and weaknesses are discussed, analyses and codes for assessment can be improved, new monitoring and strengthening methods are available and life length can be prolonged.
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| 2. |
- Bell, Brian, et al.
(författare)
-
Sustainable Bridges - Past and Future Reflections on a European Project 2003-2007
- 2023
-
Ingår i: IABSE Congress, New Delhi 2023: Engineering for Sustainable Development, Report. ; , s. 690-698
-
Konferensbidrag (refereegranskat)abstract
- Twenty years ago, in 2003, a European project was started to increase the sustainability of existing railway bridges. This paper summarises what was achieved and looks ahead. Nine Working Packages were organized: (1) Background material; (2) Guidance by stakeholders; (3) Condition Assessment and Inspection Guidelines; (4) Loads, Capacity and Resistance Guidelines; (5) Monitoring Guidelines; (6) Repair and Strengthening Guidelines; (7) Demonstration with Field testing of Bridges; (8) Demonstration on Monitoring on Bridges; and (9) Training and Dissemination Some of the main results (from 4 Guidelines and 47 Background documents) are highlighted and some experiences, conclusions and thoughts about the future are given. Hidden strengths and weaknesses are discussed, analyses and codes for assessment can be improved, new monitoring and strengthening methods are available and life length can be prolonged.
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| 3. |
- Chen, Zhishan, et al.
(författare)
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Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
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| 4. |
- Fernandez-Rozadilla, Ceres, et al.
(författare)
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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
- 2023
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 55, s. 89-99
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Tidskriftsartikel (refereegranskat)abstract
- Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
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