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Träfflista för sökning "WFRF:(Jansen T.) srt2:(2005-2009)"

Sökning: WFRF:(Jansen T.) > (2005-2009)

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  • Jansen-Olesen, I, et al. (författare)
  • Expression of inducible nitric oxide synthase in trigeminal ganglion cells during culture
  • 2005
  • Ingår i: Basic & Clinical Pharmacology & Toxicology. - 1742-7843. ; 97:6, s. 355-363
  • Tidskriftsartikel (refereegranskat)abstract
    • Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immuno reactivity within the trigeminovascular system. Sensitisation of the trigeminal system including the trigeminal ganglia neurones is believed to be involved in the pathway leading to migraine pain. In the present study, the NOS expression in rat primary trigeminal ganglia neurones was examined at different time points using immuno-cytochemistry, reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting. In trigeminal ganglia cells not subjected to culture, endothelial (e) and neuronal (n) but not inducible (i) NOS mRNA and protein were detected. Culture of rat neurotics resulted in a rapid axonal Outgrowth of NOS positive fibres. At 12, 24 and 48 hr of culture, NOS immunoreactivity was detected in medium-sized trigeminal ganglia cells. Western blotting and RT-PCR revealed an up-regulation of inducible iNOS expression during Culture. However, after Culture only low levels of eNOS protein was found while no eNOS and nNOS mRNA and protein could be detected. The data Suggest that iNOS expression may be a molecular mechanism mediating the adaptive response of trigeminal ganglia cells to the serum free stressful stimulus the Culture environment provides. It may act as a cellular signalling molecule that is expressed after cell activation.
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  • van Doremalen, Ric, et al. (författare)
  • Wireless activity monitor using 3D integration
  • 2009
  • Ingår i: Proceedings of Symposium on Design, Test, Integration and Package of MEMS/MOEMS (DTIP 2009), Rome, Italy.
  • Konferensbidrag (refereegranskat)
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  • Villa, Luisa L., et al. (författare)
  • Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
  • 2006
  • Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 24:27-28, s. 5571-5583
  • Tidskriftsartikel (refereegranskat)abstract
    • Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naive and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were similar to 12- to 26-fold higher than those observed in baseline-naive women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported. (c) 2006 Elsevier Ltd. All rights reserved.
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  • Resultat 1-7 av 7

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