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- Ahlin, Sofie, 1985, et al.
(författare)
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Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity.
- 2013
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Ingår i: Obesity (Silver Spring, Md.). - : Wiley. - 1930-739X .- 1930-7381. ; 21:12
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration. However, whether macrophage infiltration directly influences human metabolism is unclear. The aim of this study was to investigate if there are obesity-independent links between adipose tissue macrophages and metabolic disturbances. Design and Methods: Expression of macrophage markers in adipose tissue was analyzed by DNA microarrays in the SOS Sib Pair study and in patients with type 2 diabetes and a BMI-matched healthy control group. Results: The expression of macrophage markers in adipose tissue was increased in obesity and associated with several metabolic and anthropometric measurements. After adjustment for BMI, the expression remained associated with insulin sensitivity, serum levels of insulin, C-peptide, high density lipoprotein cholesterol (HDL-cholesterol) and triglycerides. In addition, the expression of most macrophage markers was significantly increased in patients with type 2 diabetes compared to the control group. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. This indicates that adipose tissue macrophages may contribute to the development of insulin resistance and dyslipidemia.
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| 5. |
- Aramrattana, Maytheewat, et al.
(författare)
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A simulation framework for cooperative intelligent transport systems testing and evaluation
- 2017
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Ingår i: Transportation Research Part F. - Kidlington : Pergamon Press. - 1369-8478 .- 1873-5517.
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Tidskriftsartikel (refereegranskat)abstract
- Connected and automated driving in the context of cooperative intelligent transport systems (C-ITS) is an emerging area in transport systems research. Interaction and cooperation between actors in transport systems are now enabled by the connectivity by means of vehicle-to-vehicle and vehicle-to-infrastructure (V2X) communication. To ensure the goals of C-ITS, which are safer and more efficient transport systems, testing and evaluation are required before deployment of C-ITS applications. Therefore, this paper presents a simulation framework—consisting of driving-, traffic-, and network-simulators—for testing and evaluation of C-ITS applications. Examples of cooperative adaptive cruise control (CACC) applications are presented, and are used as test cases for the simulation framework as well as to elaborate on potential use cases of it. Challenges from combining the simulators into one framework, and limitations are reported and discussed. Finally, the paper concludes with future development directions, and applications of the simulation framework in testing and evaluation of C-ITS. © 2017 Elsevier Ltd. All rights reserved.
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| 6. |
- Aramrattana, Maytheewat, et al.
(författare)
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Cooperative Driving Simulation
- 2016
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Ingår i: Proceedings of the Driving Simulation Conference 2016. ; , s. 123-132
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Konferensbidrag (refereegranskat)abstract
- For a few decades, driving simulators have been supporting research and development of advanced driver assistance systems (ADAS). In the near future, connected vehicles are expected to be deployed. Driving simulators will need to support evaluation of cooperative driving applications within cooperative intelligent transportation systems (C-ITS) scenarios. C-ITS utilize vehicle-to-vehicle and vehicle-to-infrastructure (V2X) communication. Simulation of the inter vehicle communication is often not supported in driving simulators. On the other hand, previous efforts have been made to connect network simulators and traffic simulators, to perform C-ITS simulations. Nevertheless, interactions between actors in the system is an essential aspect of C-ITS. Driving simulators can provide the opportunity to study interactions and reactions of human drivers to the system. This paper present simulation of a C-ITS scenario using a combination of driving, network, and traffic simulators. The architecture of the solution and important challenges of the integration are presented. A scenario from Grand Cooperative Driving Challenge (GCDC) 2016 is implemented in the simulator as an example use case. Lastly, potential usages and future developments are discussed.
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| 7. |
- Aramrattana, Maytheewat, et al.
(författare)
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Extended Driving Simulator for Evaluation of Cooperative Intelligent Transport Systems
- 2016
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Ingår i: Proceedings of the 2016 annual ACM Conference on SIGSIM Principles of Advanced Discrete Simulation (SIGSIM-PADS '16). - New York, NY, USA : ACM Digital Library. - 9781450337427 ; , s. 255-258
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Konferensbidrag (refereegranskat)abstract
- Vehicles in cooperative intelligent transport systems (C-ITS) often need to interact with each other in order to achieve their goals, safe and efficient transport services. Since human drivers are still expected to be involved in C-ITS, driving simulators are appropriate tools for evaluation of the C-ITS functions. However, driving simulators often simplify the interactions or influences from the ego vehicle on the traffic. Moreover, they normally do not support vehicle-to-vehicle and vehicle-to-infrastructure (V2X) communication, which is the main enabler for C-ITS. Therefore, to increase the C-ITS evaluation capability, a solution on how to extend a driving simulator with traffic and network simulators to handle cooperative systems is presented as a result of this paper. Evaluation of the result using two use cases is presented. And, the observed limitations and challenges of the solution are reported and discussed.
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| 8. |
- Aramrattana, Maytheewat, et al.
(författare)
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Safety Analysis of Cooperative Adaptive Cruise Control in Vehicle Cut-in Situations
- 2017
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Ingår i: Proceedings of 2017 4th International Symposium on Future Active Safety Technology towards Zero-Traffic-Accidents (FAST-zero). - : Society of Automotive Engineers of Japan.
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Konferensbidrag (refereegranskat)abstract
- Cooperative adaptive cruise control (CACC) is a cooperative intelligent transport systems (C-ITS) function, which especially when used in platooning applications, possess many expected benefits including efficient road space utilization and reduced fuel consumption. Cut-in manoeuvres in platoons can potentially reduce those benefits, and are not desired from a safety point of view. Unfortunately, in realistic traffic scenarios, cut-in manoeuvres can be expected, especially from non-connected vehicles. In this paper two different controllers for platooning are explored, aiming at maintaining the safety of the platoon while a vehicle is cutting in from the adjacent lane. A realistic scenario, where a human driver performs the cut-in manoeuvre is used to demonstrate the effectiveness of the controllers. Safety analysis of CACC controllers using time to collision (TTC) under such situation is presented. The analysis using TTC indicate that, although potential risks are always high in CACC applications such as platooning due to the small inter-vehicular distances, dangerous TTC (TTC < 6 seconds) is not frequent. Future research directions are also discussed along with the results.
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| 9. |
- Aramrattana, Maytheewat, 1988-, et al.
(författare)
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Simulation of cut-in by manually driven vehicles in platooning scenarios
- 2017
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Ingår i: IEEE Conference on Intelligent Transportation Systems, Proceedings, ITSC. - Piscataway, NJ : IEEE. - 9781538615256 - 9781538615263 - 9781538615270
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Konferensbidrag (refereegranskat)abstract
- In the near future, Cooperative Intelligent Transport System (C-ITS) applications are expected to be deployed. To support this, simulation is often used to design and evaluate the applications during the early development phases. Simulations of C-ITS scenarios often assume a fleet of homogeneous vehicles within the transportation system. In contrast, once C-ITS is deployed, the traffic scenarios will consist of a mixture of connected and non-connected vehicles, which, in addition, can be driven manually or automatically. Such mixed cases are rarely analysed, especially those where manually driven vehicles are involved. Therefore, this paper presents a C-ITS simulation framework, which incorporates a manually driven car through a driving simulator interacting with a traffic simulator, and a communication simulator, which together enable modelling and analysis of C-ITS applications and scenarios. Furthermore, example usages in the scenarios, where a manually driven vehicle cut-in to a platoon of Cooperative Adaptive Cruise Control (CACC) equipped vehicles are presented.
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| 10. |
- Axelsson, Malin, et al.
(författare)
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Respiratory symptoms increase health care consumption and affect the everyday life : a cross-sectional population-based study from Finland, Estonia and Sweden
- 2016
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Ingår i: European Clinical Respiratory Journal. - : Co-Action. - 2001-8525. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Even though respiratory symptoms are common in the adult population, there is limited research describing their impact on everyday life and association with health care consumption. Aim: The main objective of this population-based study was to estimate and compare the prevalence of respiratory symptoms among adults in Finland, Estonia, and Sweden in relation to health care consumption and to identify factors influencing health care consumption. A secondary aim was to assess to which extent the presence of respiratory symptoms affect everyday life. Method: In the population-based FinEsS studies consisting of random samples of subjects aged 20 to 69 years from Finland (n 1,337), Estonia (n 1,346), and Sweden (n 1,953), data on demographics, respiratory health, and health care consumption were collected by structured interviews. Prevalence was compared and multiple logistic regression analyses were performed. Results: Respiratory symptoms were significantly more common in Finland (66.0%) and Estonia (65.2%) than in Sweden (54.1%). Among subjects with respiratory symptoms, the proportion reporting outpatient care during the past year was fairly similar in the three countries, while specialist consultations were more common in Finland (19.1%), and hospitalisations more common in Estonia (15.0%). Finnish and Estonian residency, female sex, and BMI 25 increased the risk for outpatient care consumption. Wheeze and attacks of shortness of breath in the past 12 months, recurrent sputum production, and cough were associated with an increased risk for health care consumption. Increasing number of respiratory symptoms increased the risk for consuming health care. A larger proportion of subjects in Estonia and Sweden experienced their everyday life being affected by respiratory symptoms compared with subjects in Finland. Conclusion: Respiratory symptoms are common in Finland, Estonia, and Sweden and contribute to a negative impact on everyday life as well as increased health care consumption. The observed differences in health care consumption between countries are probably related to national differences in health care structure.
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