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- Boström, R., Eriksson, A.I., Åhlén, L., Blomberg, L., Gustafsson, G., Holback, B., Holmgren, G., Holtet, J., Jansson, S.E., Lindqvist, P.A., Lybekk, B., Mälkki, A., Riihelä, P. and Wahlund, J.E.
(författare)
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The Rosetta Dual Langmuir Probe Instrument for Measurements of Plasma Density, Temperature and Flow Velocity.
- 2001
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Ingår i: ESA SP-1165.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Hallgren, C G, et al.
(författare)
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Markers of high fish intake are associated with decreased risk of a first myocardial infarction
- 2001
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Ingår i: British Journal of Nutrition. - 1475-2662. ; 86:3, s. 397-404
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Tidskriftsartikel (refereegranskat)abstract
- High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors.
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| 7. |
- Plymoth, A., et al.
(författare)
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Human bronchoalveolar lavage: biofluid analysis with special emphasis on sample preparation
- 2003
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Ingår i: Proteomics. ; 3:6
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Tidskriftsartikel (refereegranskat)abstract
- Respiratory diseases are an important health problem throughout the world. Whether caused by industrial pollutants, infections, smoking, cancer or metabolic diseases, damage to the lungs and airways often lead to morbidity or death. Bronchoalveolar lavage (BAL) obtained by fiber-optic bronchoscopy is a biofluid mirroring the expression of normally secreted pulmonary proteins and the products of activated cells and destructive processes. The characterization of the proteome within this compartment provides an opportunity to establish temporal and prognostic indicators of airway disease. The objective of this study was to develop methods of analysis of BAL samples, which achieved the highest level of annotation of the expression map of this proteome. We have optimized the process of sample preparation after investigating a variety of techniques including dialysis, ultramembrane filtration, precipitation and gel filtration. We have further studied methods to remove albumin from BAL in order to unmask proteins hidden on two-dimensional gels. In a pilot application of the method, BAL protein profiles obtained from healthy nonsmokers and smokers at risk for developing chronic obstructive pulmonary disease showed distinct differences.
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| 9. |
- Thøgersen, AM, et al.
(författare)
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Homozygosity for the C677-->T mutation of 5,10-methylenetetrahydrofolate reductase and total plasma homocyst(e) ine are not associated with greater than normal risk of a first myocardial infarction in northern Sweden
- 2001
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Ingår i: Coronary Artery Disease. - 0954-6928 .- 1473-5830. ; 12:2, s. 85-90
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Results of several case-control studies have shown elevated total plasma homocyst(e)ine (TPH) and homozygosity for the point mutation C677-->T in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) to be associated with a greater than normal risk of atherosclerotic vascular disease. However, there have been few epidemiologic studies and the interpretation of the results is not clear-cut. OBJECTIVE: To elucidate whether homozygosity for the point mutation C677-->T in the gene for MTHFR, and TPH are risk factors for a first myocardial infarction. DESIGN: A prospective nested case-control study in Northern Sweden. METHODS: Among more than 36000 persons screened, 78 cases satisfied the inclusion criterion of having developed, after sampling, a first myocardial infarction. For each case, two controls matched for sex and age were randomly selected. RESULTS: We found no statistically significant difference among the prevalences of the three possible MTHFR genotypes -/- (no mutation), +/+ (both alleles have the mutation), and +/- among cases and controls in univariate conditional logistic regression analysis. Mean levels of TPH in patients and controls were 12.2+/-4.9 and 12.2+/-3.5 micromol/l (means +/- SD), respectively (NS). CONCLUSIONS: In this study neither homozygosity for the point mutation C677-->T in the gene for MTHFR nor TPH was related to a greater than normal risk of a first myocardial infarction for members of the population of northern Sweden. Further research is needed in order to show whether TPH is an independent risk factor for a first myocardial infarction.
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| 10. |
- Agrell, J., et al.
(författare)
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Production of hydrogen by partial oxidation of methanol over Cu/ZnO catalysts prepared by microemulsion technique
- 2001
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Ingår i: Applied Catalysis A. - 0926-860X .- 1873-3875. ; 211:2, s. 239-250
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Tidskriftsartikel (refereegranskat)abstract
- Production of hydrogen by partial oxidation of methanol, using air as oxidant. has been studied over a series of Cu/ZnO catalysts prepared by microemulsion technique. The catalytic activity was compared to that of a reference catalyst prepared by conventional co-precipitation. The BET surface areas of the microemulsion catalysts (30-70 wt.% Cu) ranged from 22 to 36 m(2)/g and were considerably lower than that of the reference (60 m(2)/g). Nevertheless, the microemulsion catalysts were more active in the partial oxidation reaction and exhibited high hydrogen and carbon dioxide selectivities. At a molar O-2/CH3OH ratio of 0.1, hydrogen production was initiated at about 185 degreesC over the microemulsion catalysts. Over the reference, hydrogen production began at 215 degreesC under the same conditions. The catalytic activity was Found to be strongly dependent on the partial pressure of oxygen, which also plays an important role in determining the product distribution. By increasing the O-2/CH3OH ratio, the methanol conversion and carbon dioxide selectivity increase. while production of water occurs at the expense of hydrogen. By TEM and TPR, it was observed that Cu is less well-dispersed in the microemulsion catalysts than in the reference. The higher catalytic activity is not expected considering the lower number of exposed Cu sites, i.e, the turnover frequencies are substantially higher over the microemulsion catalysts. It is possible that, a strong interaction between a small part of CuO and the ZnO lattice is responsible for the higher turnover frequencies of the microemulsion catalysts, or that particular crystallographic Cu planes or surface imperfections are the active sites of the reaction.
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