| 1. |
- García, Maria C, et al.
(författare)
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Mature-onset obesity in interleukin-1 receptor I knockout mice.
- 2006
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:5, s. 1205-13
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Tidskriftsartikel (refereegranskat)abstract
- Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its biological activities through the IL-1 type I receptor (IL-1RI). The body weights of IL-1RI(-/-) mice of both sexes started to deviate from those of wild-type mice at 5-6 months of age and were 20% higher at 9 months of age. Visceral and subcutaneous fat mass, measured by dual-energy X-ray absorptiometry and magnetic resonance imaging, was markedly (1.5- to 2.5-fold) increased. Lean body mass and crown-rump length were also slightly (11 and 5%, respectively) increased, as was serum IGF-I. Obese IL-1RI(-/-) mice were insulin resistant, as evidenced by hyperinsulinemia, decreased glucose tolerance, and insulin sensitivity. To elucidate the mechanisms for the development of obesity, young pre-obese IL-1RI(-/-) mice were investigated. They showed decreased suppression of body weight and food intake in response to systemic leptin treatment. The decreased leptin responsiveness was even more pronounced in older obese animals. Moreover, spontaneous locomotor activity and fat utilization, as measured by respiratory quotient, were decreased in pre-obese IL-1RI(-/-) mice. In conclusion, lack of IL-1RI-mediated biological activity causes mature-onset obesity. This obese phenotype is preceded by decreased leptin sensitivity, fat utilization, and locomotor activity.
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| 2. |
- Hagman, C, et al.
(författare)
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Reproducibility of tryptic digestion investigated by quantitative fourier transform ion cyclotron resonance mass spectrometry
- 2005
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 4:2, s. 394-399
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Tidskriftsartikel (refereegranskat)abstract
- In this study, the reproducibility of tryptic digestion of complex solutions was investigated using liquid chromatography Fourier transform ion cyclotron resonance (LC FT-ICR) mass spectrometry. Tryptic peptides, from human cerebrospinal fluid, (CSF) were labeled with Quantification-Using-Enhanced-Signal-Tags (QUEST)-markers, or 1-([H-4]nicotinoyloxy)- and 1-([D-4]nicotinoyloxy)-succinimide ester markers. The analysis was performed on abundant proteins with respect-to-intensity ratios and sequence coverage and obtained by comparing differently labeled components from one or different pools. To interpret the dynamics in the proteome, one must be able to estimate the error introduced in each experimental steps. The intra sample variation due to derivatization was approximately 10%. The inter sample variation depending on derivatization and tryptic digestion was not more than approximately 30%. These experimental observations provide a range for the up- and clown-regulations that are possible to study with electrospray ionization LC FT-ICR mass spectrometry.
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| 6. |
- Jansson, Maria, 1968-, et al.
(författare)
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"Heja Uffe!" : Så legitimeras mäns överordning
- 2006
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Ingår i: Kvinnovetenskaplig tidskrift. - Göteborg : Föreningen Kvinnovetenskaplig tidskrift. - 0348-8365. ; :4, s. 7-27
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Tidskriftsartikel (refereegranskat)abstract
- In this article we analyze the messages inherent in, and the public receptions of, four campaigns in Stockholm during the 1990:s and 2000:s concerning male violence against women. The campaigns are produced by "Operation Kvinnofrid" ("Operation Women's inviolability") - a cooperation of authorities in Stockholm headed by the Maier. Our purpose is to discuss in what ways it is possible to formulateand describe men's violence against women in the public arena. How is the problem of men's violence against women represented in the campaigns? What are the reactions to the campaigns and how are they to be understood? We argue that the sometimes very aggressive reactions are provoked when the campaigns put into question relations that are important to men as well as to the support and maintenance of the gender power order. Here we focus men's relations to other men, men's relations to politics and the political system, men's relations to children and, finally, men's relations to the "Nation". How are these relations challenged and/or legitimized, and how do they intertwine with gender power? Our findings suggest that when the position of men, as benevolent and protective actors that form a positive male genealogy, is challenged by the campaign, aggressive reactions are stirred up and the legitimacy of the authorities are questioned. These reactions are paired with an upsurge of "male cheering" - supportive stories about men and, especially, Swedish men and fathers. A tentative interpretation of this is that male cheering is an important way of maintaining the gender power order, especially when this order occasionally is questioned.
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| 7. |
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| 8. |
- Jansson, Maria, 1968-, et al.
(författare)
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Kön och nation i vardag och vetenskap
- 2007
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Ingår i: Statsvetenskaplig Tidskrift. - Lund : Fahlbeckska stiftelsen. - 0039-0747. ; 109:3, s. 241-258
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Tidskriftsartikel (refereegranskat)abstract
- Understanding gender and nation in everyday practises and social science. The nation is often portrayed as a natural political unit, a bearer of common values facilitating democracy and equality. However, the construction and reproduction of nations is also intimately tied to hierarchies and mechanisms of power, not least gender power. This article shows how nation and gender are construed simultaneously in ideas and symbols, as well as in every-day practises. The article argues that memory work is a possible way to gain insight into the every-day construction of gender and nation, and to develop new theoretical understandings. An overview of central themes of the discussion on gender and nation is presented. Memory work makes explicit the ambivalent processes by which women as acting subjects are denied agency and turned into objects of the nation.
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| 9. |
- Jansson, Maria, et al.
(författare)
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Memory Work Reconsidered
- 2008
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Ingår i: NORA: Nordic Journal of Feminist and Gender Research. ; 16:14, s. 228-240
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Jansson, Maria, 1968-, et al.
(författare)
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Memory Work Reconsidered
- 2008
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Ingår i: NORA. - : Routledge. - 0803-8740 .- 1502-394X. ; 16:14, s. 228-240
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Tidskriftsartikel (refereegranskat)abstract
- In this article we discuss the epistemological status of the knowledge and understandings that a specific way of working with women's experiences—memory work—generates. This discussion is held in the light of the last decades' feminist debate on the risks and problems inherent in research taking women's experience as a point of departure. We put forward memory work as a fruitful method of working scientifically with experiences, especially when it comes to understanding deeply naturalized power structures such as gender, nation, and sexuality. We show how different interpretative modes and practices in memory work may help us locate ruptures and ambivalences in the already known, and open up for understandings and interpretations that take us beyond the discursively given. However, several epistemological as well as methodological issues need to be addressed in order for memory work to render possible new forms of understanding that reach beyond established discourses and concepts. To avoid the much‐debated risk of essentialism and reproduction of different power structures, we argue that a great deal of reflection is required when elaborating research techniques. It is thereby necessary to carefully design the different steps in the process of memory work. This article shows how different ways of handling methodological problems in memory work—concerning foremost the choice of theme for the memory project, the textual practices used when writing memory stories, and the modes of interpretation employed—are crucial for what kind of analysis is made possible. We also highlight the importance of displacing the research problem at a certain distance from the theme of the project. The concepts of transferring and dislocating the research problem are introduced as a means to elucidate how different types of displacement generate different research results.
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