| 1. |
- Blomdin, Robin, et al.
(författare)
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Timing of the deglaciation in Southern Patagonia : testing the applicability of k feldspar irsl
- 2012
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Ingår i: Quaternary Geochronology. - : Elsevier BV. - 1871-1014 .- 1878-0350. ; 10, s. 264-272
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Tidskriftsartikel (refereegranskat)abstract
- The timing of the ice margin retreat of the Late Glacial Patagonian Ice Sheet (PIS) in southern Patagonia has been the object of discussion for many years. In order to resolve questions about the complex response of the PIS to past climate change, any geological interpretation and data modelling need evaluation against an absolute chronology. The aim of this project is to investigate the applicability of OSL dating to sediments from southern Patagonia; in particular, we examine the dating potential of K-feldspar IRSL signals. Samples were collected from landforms interpreted as being deposited during deglaciation of the PIS, with an expected age range of 17 and 22 ka, and from recently deposited sediment. We measure small aliquots and single grain distributions using an IR50 SAR protocol with IRSL stimulation at 50 degrees C following a preheat at 250 degrees C (held for 60 s). Uncertainties are assigned to our individual dose estimates based on the over-dispersion (OD) observed in laboratory gamma dose recovery experiments (22% for small aliquots and 18% for single grains). Then the possible effects of incomplete bleaching and differential fading are examined. For our natural samples we observe environmental ODs between 30 and 130% and mean residual doses between similar to 30 and 80 Gy. Minimum age models are used to identify the part of the dose population that is most likely to have been well-bleached and results from these models are compared. The models give ages that are consistent with each other; this may imply that they successfully identified the fully-bleached grains in the distributions, although there are some discrepancies between our small aliquot and single grain data. We observe large fading rates (on average 7.9 +/- 0.6%/decade for large aliquots) but nevertheless a comparison of our fading corrected ages with the expected age range shows that 2 out of 3 ages are consistent with geological interpretation and an established radiocarbon and cosmogenic nuclide chronology. We conclude that these investigations suggest that fading corrections can be based on laboratory average small aliquot/single grain fading rates. The third age is supported by an alternative geological interpretation, and the two ages consistent with the existing chronology imply that in the Strait of the Magellan the hills of the Brunswick peninsula (>70 m.a.s.l) were deglaciated at around 22 ka.
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| 2. |
- Coviello, Andrea D, et al.
(författare)
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A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
- 2012
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 8:7
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Tidskriftsartikel (refereegranskat)abstract
- Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations. Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p=1.8×10(-106)), PRMT6 (rs17496332, 1p13.3, p=1.4×10(-11)), GCKR (rs780093, 2p23.3, p=2.2×10(-16)), ZBTB10 (rs440837, 8q21.13, p=3.4×10(-09)), JMJD1C (rs7910927, 10q21.3, p=6.1×10(-35)), SLCO1B1 (rs4149056, 12p12.1, p=1.9×10(-08)), NR2F2 (rs8023580, 15q26.2, p=8.3×10(-12)), ZNF652 (rs2411984, 17q21.32, p=3.5×10(-14)), TDGF3 (rs1573036, Xq22.3, p=4.1×10(-14)), LHCGR (rs10454142, 2p16.3, p=1.3×10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p=2.7×10(-08)), and UGT2B15 (rs293428, 4q13.2, p=5.5×10(-06)). These genes encompass multiple biologic pathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptor function, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer. We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 was significant in men only (men p=2.5×10(-08), women p=0.66, heterogeneity p=0.003). Additionally, three loci showed strong sex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger in women. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion of variance explained at the locus. Using an independent study of 1,129 individuals, all SNPs identified in the overall or sex-differentiated or conditional analyses explained ∼15.6% and ∼8.4% of the genetic variation of SHBG concentrations in men and women, respectively. The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance.
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| 3. |
- Ohlsson, Claes, 1965, et al.
(författare)
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Genetic determinants of serum testosterone concentrations in men.
- 2011
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 7:10
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Tidskriftsartikel (refereegranskat)abstract
- Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n=871) and two de novo replication cohorts (n=4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as <300 ng/dl. Two single-nucleotide polymorphisms at the sex hormone-binding globulin (SHBG) locus (17p13-p12) were identified as independently associated with serum testosterone concentration (rs12150660, p=1.2×10(-41) and rs6258, p=2.3×10(-22)). Subjects with ≥ 3 risk alleles of these variants had 6.5-fold higher risk of having low serum testosterone than subjects with no risk allele. The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p=5.6×10(-16)). The rs6258 polymorphism in exon 4 of SHBG affected SHBG's affinity for binding testosterone and the measured free testosterone fraction (p<0.01). Genetic variants in the SHBG locus and on the X chromosome are associated with a substantial variation in testosterone concentrations and increased risk of low testosterone. rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation.
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| 4. |
- Olsson, Robin, et al.
(författare)
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Strength of NCF composite bundles under biaxial stress
- 2011
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Ingår i: Composite materials for structural performance: towards higher limits. - Roskilde : Risø National Laboratory for Sustainable Energy, Danmarks Tekniske Universitet. - 9788755039254
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Konferensbidrag (refereegranskat)
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| 5. |
- Olsson, Robin, et al.
(författare)
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Strength of NCF composite bundles under biaxial stress
- 2011
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Ingår i: Proc. 32nd Risø International Symposium on Materials Science. - Roskilde, Denmark : Risø National Laboratory for Sustainable Energy, DTU, Denmark. - 9788755039254 ; , s. 415-421
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Konferensbidrag (refereegranskat)abstract
- This paper presents experiments to support development of mesomechanics models for prediction of the strength of Non-Crimp Fabric (NCF) materials under tri-axial loading. Here we describe initial tests to characterise the failure envelope of the material in fibre bundles of a carbon fibre/epoxy NCF. Uniaxial loading of unidirectional off-axis specimens is used to obtain in-plane stress states ranging from highly shear dominated to fully transverse or axial tension, while future tests will include compressive stresses. The bundle material is represented by filament winding of unidirectional laminates and subsequent vacuum infusion of the resin. The resulting fibre volume fraction of 69% is representative of typical bundles in NCF materials. A modified Puck failure criterion provides reasonable predictions of the failure envelope.
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| 6. |
- Olsson, Robin, et al.
(författare)
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Testing of carbon/epoxy NCF strength under mixed in-plane loading
- 2012
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Ingår i: Proceedings of the 15th European Conference on Composite Materials. - Venice : European Conference on Composite Materials, ECCM. - 9788888785332
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Konferensbidrag (refereegranskat)abstract
- The measured stiffness and strength of a carbon/epoxy unidirectional NCF system in shear, tension and compression are compared with test results for the pure resin and for impregnated bundle material under various combinations of in-plane compressive and tensile loading. The study is a part of a project to develop mesomechanics models to predict failure of NCF materials under triaxial loading by use of data for the pure resin and for bundles impregnated by resin. A simplified analytical rule-of-mixtures model is suggested for stiffness and strength of the NCF material. Good agreement is shown for shear and tension along and transverse to the bundles. Compressive strengths are significantly underestimated, apparently due to deficiencies in the compressive test method used for the bundle material.
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