| 1. |
- Sundström, Johan, Professor, 1971-, et al.
(författare)
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A registry-based randomised trial comparing an SGLT2 inhibitor and metformin as standard treatment of early stage type 2 diabetes (SMARTEST): Rationale, design and protocol
- 2021
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Ingår i: Journal of Diabetes and Its Complications. - : Elsevier BV. - 1056-8727 .- 1873-460X. ; 35:10
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Tidskriftsartikel (refereegranskat)abstract
- Aim: SGLT2 inhibitors have been shown to reduce cardiovascular and renal complications in type 2 diabetes (T2D) patients at high cardiovascular risk. Metformin is currently widely used as initial monotherapy in T2D but lacks convincing data to show that it reduces risk of complications. We aim to compare the SGLT2 inhibitor dapagliflozin and metformin as first-line T2D medication with regard to development of complications in a registry-based randomised controlled trial. Methods: The SGLT2 inhibitor or metformin as standard treatment of early stage type 2 diabetes (SMARTEST) trial will enrol 4300 subjects at 30-40 study sites in Sweden who will be randomised 1:1 to either metformin or dapagliflozin. Participants must have T2D duration <4 years, no prior cardiovascular disease, and be either drug-naive or on monotherapy for T2D. Results: The primary endpoint is a composite of all-cause death, major adverse cardiovascular events and occurrence or progression of microvascular complications (retinopathy, nephropathy, diabetic foot lesions). Secondary endpoints include individual components of the primary endpoint, start of insulin therapy, risk factor biomarkers, patient-reported outcome measures, and cost-effectiveness analysis. Outcomes will primarily be assessed using nationwide healthcare registries. Conclusions: The SMARTEST trial will investigate whether dapagliflozin is superior to metformin in preventing complications in early stage T2D. (Clinicaltrials.gov identifier NCT03982381, EudraCT 2019-001046-17).
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| 2. |
- Ekelund, Robin, et al.
(författare)
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An empirical history
- 2022
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Ingår i: Historisk Tidskrift. - : SVENSKA HISTORISKA FORENINGEN. - 0345-469X .- 2002-4827. ; 142:3, s. 307-319
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Ekelund, Robin, et al.
(författare)
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En empirisk historia [An empirical history]
- 2022
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Ingår i: Historisk Tidskrift. - : Svenska Historiska Föreningen. - 0345-469X .- 2002-4827. ; 142:3, s. 307-319
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Erzurumluoglu, A. Mesut, et al.
(författare)
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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
- 2020
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Ingår i: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:10, s. 2392-2409
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Tidskriftsartikel (refereegranskat)abstract
- Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10-8 in either analysis were taken forward for replication in up to 275,596 independent participants from UK Biobank. Lastly, a meta-analysis of the discovery and replication studies was performed. Sixteen SNVs were associated with at least one of the smoking behaviour traits (P < 5 × 10-8) in the discovery samples. Ten novel SNVs, including rs12616219 near TMEM182, were followed-up and five of them (rs462779 in REV3L, rs12780116 in CNNM2, rs1190736 in GPR101, rs11539157 in PJA1, and rs12616219 near TMEM182) replicated at a Bonferroni significance threshold (P < 4.5 × 10-3) with consistent direction of effect. A further 35 SNVs were associated with smoking behaviour traits in the discovery plus replication meta-analysis (up to 622,409 participants) including a rare SNV, rs150493199, in CCDC141 and two low-frequency SNVs in CEP350 and HDGFRP2. Functional follow-up implied that decreased expression of REV3L may lower the probability of smoking initiation. The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.
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| 5. |
- Forsman, Åsa, 1972-, et al.
(författare)
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Riding in a safe system – workshop on safety for powered-two-wheelers : final report from a workshop held on 9–13 June 2021
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- An international workshop on safety for powered-two-wheelers (PTWs), Riding in a safe system, was held as a series of virtual meetings 9–23 June 2021. The workshop was co-organised by the International Transport Forum (ITF), the Swedish Transport Administration, the International Motorcycling Federation (FIM), the motorcycle manufacturers associations (IMMA and ACEM), and the Swedish National Road and Transport Research Institute (VTI). The workshop was a follow-up of the Third Global Ministerial Conference on Road Safety, held in Stockholm in February 2020, but it also built on a previous workshop in 2008 in Lillehammer and the 2015 ITF research report “Improving Safety for Motorcycle, Scooter and Moped Riders”. The workshop, which included six expert sessions, focused on seven different areas: (i) Sustainable practices, work-related issues and procurement, (ii) Modal shift and urban needs, (iii) Training, education, and licensing, (iv) Vehicle safety, protective safety, and Intelligent Transport Systems, (v) Road infrastructure and road environment, (vi) Speed management, adapting speeds and behaviour to different environments, (vii) Youth and child safety. Eight priority actions were recognized by the workshop to achieve the integration of PTWs in the safe system by 2030. These actions build on the Stockholm declaration and its 9 recommendations. The actions are generalized results from the outcome of the expert sessions. The 8 priority actions from the workshop are: (i) Move to sustainable practice, (ii) Support modal shift, (iii) Adopt safe vehicles and equipment, (iv) Educate safe riders, (v) Redesign infrastructure, (vi) Ensure safe speed, (vii) Protect children, and (viii) increase knowledge.
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| 6. |
- Hassan Jansson, Karin, 1966-, et al.
(författare)
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En empirisk historia
- 2022
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Ingår i: Historisk Tidskrift. - : Svenska Historiska Föreningen. - 0345-469X .- 2002-4827. ; 142:3, s. 307-319
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
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| 9. |
- Urbanič, Gorazd, et al.
(författare)
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Riparian Zones—From Policy Neglected to Policy Integrated
- 2022
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Ingår i: Frontiers in Environmental Science. - : Frontiers Media SA. - 2296-665X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- 1. Riparian zones are vital areas of interaction between land and rivers and are often degraded by several pressures such as urbanisation, intensive agriculture and river engineering works. 2. This policy brief provides five key policy messages and recommendations to be considered by policy-makers, scientists, managers, and stakeholders to enhance riparian zone management. 3. Adopting an integrated socio-economic and environmentally dynamic view will ensure the sustainable management of riparian zones. 4. In light of climate change, it is critically important to conserve and/or restore the ecological integrity of riparian zones. 5. European Union Directives and national-scale legislation and regulations need updating to ensure coordinated implementation of riparian zone-related policies. 6. Stakeholder knowledge exchange, policy co-creation and adaptive management are key to enhancing riparian zone functions.
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| 10. |
- Åkesson, Sofia, et al.
(författare)
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Characterizing natural degradation of tetrachloroethene (PCE) using a multidisciplinary approach
- 2020
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Ingår i: Ambio: a Journal of the Human Environment. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 50, s. 1074-1088
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Tidskriftsartikel (refereegranskat)abstract
- A site in mid-western Sweden contaminated with chlorinated solvents originating from a previous dry cleaning facility, was investigated using conventional groundwater analysis combined with compound-specific isotope data of carbon, microbial DNA analysis, and geoelectrical tomography techniques. We show the value of this multidisciplinary approach, as the different results supported each interpretation, and show where natural degradation occurs at the site. The zone where natural degradation occurred was identified in the transition between two geological units, where the change in hydraulic conductivity may have facilitated biofilm formation and microbial activity. This observation was confirmed by all methods and the examination of the impact of geological conditions on the biotransformation process was facilitated by the unique combination of the applied methods. There is thus significant benefit from deploying an extended array of methods for these investigations, with the potential to reduce costs involved in remediation of contaminated sediment and groundwater.
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