| 1. |
- Berndt, Sonja I., et al.
(author)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Journal article (peer-reviewed)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 2. |
- Eeg-Olofsson, Måns, 1967, et al.
(author)
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BCI-bone conduction implant.
- 2013
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In: The Fourth International Symposium on Bone Conduction Hearing – Craniofacial Osseointegration. Newcastle, UK.
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Conference paper (other academic/artistic)
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| 3. |
- Eeg-Olofsson, Måns, 1967, et al.
(author)
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Evaluation of bone tissue formation in a flat surface attachment of a Bone Conduction Implant - A pilot study in a sheep model
- 2014
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In: Audiology & Neurotology Extra. - : S. Karger AG. - 1664-5537. ; 4:3, s. 62-76
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Journal article (peer-reviewed)abstract
- The Bone Conduction Implant (BCI) is a new bone conduction hearing device implanted under intact skin. The transducer has a flat direct contact to the mastoid part of the temporal bone and no screws are used. The sound signal is transmitted from the external audio processor to the implant by means of magnetic induction. In this study, osseointegration of a flat passive BCI transducer dummy in sheep skulls was assessed using quantitative and qualitative histology as well as Cone Beam Computed Tomography (CBCT) and Computed Tomography (CT). The histology results were also related to the mechanical properties of the bone to implant interface. Eight months after the surgical implantation, histology sections of the bone close to the implant showed bone remodelling, compact bone and some degree of osseointegration. The histological findings corresponded well to the mechanical measurements indicating stiffer bone close to the implant, and unaffected skull vibration transmission. Neither CBCT nor CT had enough resolution to visualize the bone to implant interface in detail. In this study, using an animal model, it is shown that a flat implant in contact with bone, can be a feasible method for efficient vibration transmission to the skull bone.
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| 4. |
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| 5. |
- Fredén Jansson, Karl-Johan, 1988, et al.
(author)
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MRI Induced Torque and Demagnetization in Retention Magnets for a Bone Conduction Implant
- 2014
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In: IEEE Transactions on Biomedical Engineering. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9294 .- 1558-2531. ; 61:6, s. 1887-1893
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Journal article (peer-reviewed)abstract
- Performing magnetic resonance imaging (MRI) examinations in patients who use implantable medical devices involve safety risks both for the patient and the implant. Hearing implants often use two permanent magnets, one implanted and one external, for the retention of the external transmitter coil to the implanted receiver coil to achieve an optimal signal transmission. The implanted magnet is subjected to both demagnetization and torque, magnetically induced by the MRI scanner. In this paper, demagnetization and a comparison between measured and simulated induced torque is studied for the retention magnet used in a bone conduction implant (BCI) system. The torque was measured and simulated in a uniform static magnetic field of 1.5 T. The magnetic field was generated by a dipole electromagnet and permanent magnets with two different types of coercive fields were tested. Demagnetization and maximum torque for the high coercive field magnets was 7.7% +/- 2.5% and 0.20 +/- 0.01 Nm, respectively and 71.4% +/- 19.1% and 0.18 +/- 0.01 Nm for the low coercive field magnets, respectively. The simulated maximum torque was 0.34 Nm, deviating from the measured torque in terms of amplitude, mainly related to an insufficient magnet model. The BCI implant with high coercive field magnets is believed to be magnetic resonance (MR) conditional up to 1.5 T if a compression band is used around the skull to fix the implant. This is not approved and requires further investigations, and if removal of the implant is needed, the surgical operation is expected to be simple.
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| 6. |
- Speliotes, Elizabeth K., et al.
(author)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Journal article (peer-reviewed)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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