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| 2. |
- Brydegaard, Mikkel, et al.
(författare)
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Short-Wave infrared atmospheric scheimpflug lidar
- 2018
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Ingår i: EPJ Web of Conferences. - : EDP Sciences. ; 176
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Konferensbidrag (refereegranskat)abstract
- Atmospheric dual-band Scheimpflug lidar is demonstrated at 980 and 1550 nm. Signals are compared during three weather conditions, and the spatio-temporal resolution of the atmospheric structure is considered. The potential for aerosol classification is evaluated, and future directions are discussed.
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| 3. |
- Brydegaard, Mikkel, et al.
(författare)
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The Scheimpflug lidar method
- 2017
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Ingår i: Lidar Remote Sensing for Environmental Monitoring 2017. - : SPIE. - 9781510612693 ; 10406
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Konferensbidrag (refereegranskat)abstract
- The recent several years we developed the Scheimpflug lidar method. We combined an invention from the 19th century with modern optoelectronics such as diode lasers and CMOS array from the 21st century. The approach exceeds expectations of background suppression, sensitivity and resolution beyond known from time-of-flight lidars. We accomplished multiband elastic atmospheric lidars for resolving single particles and aerosol plumes from 405 nm to 1550 nm. We pursued hyperspectral differential absorption lidar for molecular species. We demonstrated a simple method of inelastic hyperspectral lidar for profiling aquatic environments and vegetation structure. Not least, we have developed polarimetric Scheimpflug lidar with multi-kHz sampling rates for remote modulation spectroscopy and classification of aerofauna. All these advances are thanks to the Scheimpflug principle. Here we give a review of how far we have come and shed light on the limitations and opportunities for future directions. In particular, we show how the biosphere can be resolved with unsurpassed resolution in space and time, and share our expectation on how this can revolutionize ecological analysis and management in relation to agricultural pests, disease vectors and pollinator problematics.
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| 4. |
- Evertsson, Maria, et al.
(författare)
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Revolving permanent magnet causes rotating particle motion that makes new detection schemes possible in magnetomotive ultrasound
- 2019
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Ingår i: 2019 IEEE International Ultrasonics Symposium, IUS 2019. - 1948-5727 .- 1948-5719. - 9781728145976 - 9781728145969 ; 2019-October, s. 2373-2375
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Konferensbidrag (refereegranskat)abstract
- Magnetomotive ultrasound, MMUS, can reveal the presence of a magnetic contrast agent by applying an external magnetic field. If the interaction between the agent and the field is strong enough, a movement that can be detected by ultrasound is induced in the surrounding tissue, thereby inferring the contrast agent distribution. Electromagnets have been used to generate the necessary magnetic field, but due to their size, weight, and propensity to heat up, they are impractical to work with. Furthermore, the resulting magnetic force is directed mainly along the symmetry axis of such magnets, and thus the resulting movement is primarily a one-dimensional oscillation. We suggest the use of a rotating permanent magnet that generates a two-dimensional particle motion, and that this makes new detection schemes for MMUS possible. A prototype probe, containing a rotating neodymium magnet, was used to move a metallic sphere embedded in tissue-mimicking material. Cine loops recorded any in-plane movement with the magnetic probe placed in two different positions. A two-dimensional movement was demonstrated, using both our previously developed MMUS algorithm as well as a phase-based motion tracking algorithm. The conventional 1D MMUS processing detected the axial component in both magnetic probe positions, whereas the two-dimensional motion tracking algorithm estimated a rotational motion from the same measurements. The added dimension of motion could engender possibilities to more precise signal processing and thus improve robustness of magnetomotive motion detection. Moreover, the incorporation of a permanent magnet makes for a more practical device, as compared to using electromagnets.
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| 5. |
- Malmqvist, Elin, et al.
(författare)
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Effective parameterization of laser radar observations of atmospheric fauna
- 2016
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Ingår i: IEEE Journal of Selected Topics in Quantum Electronics. - 1077-260X. ; 22:3
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Tidskriftsartikel (refereegranskat)abstract
- The pace at which the world's ecosystems and biodiversity of, e.g., pollinators decline is currently at a rate where it is challenging to document. In recent years, our group has made an effort to bridge the disciplines of laser remote sensing and biophotonics, and we have developed lidar methods for inventorying the biosphere. Here, we present an effective method for extracting fauna observations from atmospheric lidar data and reducing the observations to a set of descriptive parameters. Kilohertz-lidar data are used, the essential steps are walked through and a glimpse of the obtainable data product is presented.
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| 6. |
- Nicolas, Aude, et al.
(författare)
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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- 2018
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Ingår i: Neuron. - : Cell Press. - 0896-6273 .- 1097-4199. ; 97:6, s. 1268-1283.e6
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Tidskriftsartikel (refereegranskat)abstract
- To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.
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| 7. |
- Sjostrand, Sandra, et al.
(författare)
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Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging : Assessment of sensitivity and resolution to detect alterations in tissue stiffness
- 2019
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Ingår i: 2019 IEEE International Ultrasonics Symposium, IUS 2019. - 1948-5719 .- 1948-5727. - 9781728145976 - 9781728145969 ; 2019-October, s. 1077-1080
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Konferensbidrag (refereegranskat)abstract
- A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.
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| 8. |
- Sjostrand, Sandra, et al.
(författare)
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Revolving Permanent Magnet for Magnetomotive Ultrasound
- 2018
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Ingår i: 2018 IEEE International Ultrasonics Symposium, IUS 2018. - 9781538634257 ; 2018-October
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Konferensbidrag (refereegranskat)abstract
- In magnetomotive ultrasound (MMUS), solenoids have been extensively used to generate varying magnetic fields, that act to move nanoparticles and their surrounding tissue. Here we show, compare and contrast two magnetic devices, one based on a solenoid, another containing a rotating permanent magnet. Suitable field characteristics for this application include high flux density and gradient, and uniform field laterally in the image plane, and the corresponding design features are highlighted. Field measurements show that both magnets generate suitable fields. The magnetic force potentially exerted by the permanent magnet even exceeds that of the solenoid up to a depth of 4 mm. Considering the substantial heat generation in high inductance electromagnets, a permanent magnet would be preferable as it eliminates the need for cooling. Thus, we suggest the use of permanent magnets in MMUS devices to reduce the size, while maintaining a high field and gradient required to move nanoparticles.
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| 9. |
- Weidemann, Eva, et al.
(författare)
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14th congress of combustion by-products and their health effects-origin, fate, and health effects of combustion-related air pollutants in the coming era of bio-based energy sources
- 2016
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Ingår i: Environmental Science and Pollution Research. - : Springer Science and Business Media LLC. - 0944-1344 .- 1614-7499. ; 23:8, s. 8141-8159
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Tidskriftsartikel (refereegranskat)abstract
- The 14th International Congress on Combustion By-Products and Their Health Effects was held in UmeAyen, Sweden from June 14th to 17th, 2015. The Congress, mainly sponsored by the National Institute of Environmental Health Sciences Superfund Research Program and the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, focused on the Origin, fate and health effects of combustion-related air pollutants in the coming era of bio-based energy sources. The international delegates included academic and government researchers, engineers, scientists, policymakers and representatives of industrial partners. The Congress provided a unique forum for the discussion of scientific advances in this research area since it addressed in combination the health-related issues and the environmental implications of combustion by-products. The scientific outcomes of the Congress included the consensus opinions that: (a) there is a correlation between human exposure to particulate matter and increased cardiac and respiratory morbidity and mortality; (b) because currently available data does not support the assessment of differences in health outcomes between biomass smoke and other particulates in outdoor air, the potential human health and environmental impacts of emerging air-pollution sources must be addressed. Assessment will require the development of new approaches to characterize combustion emissions through advanced sampling and analytical methods. The Congress also concluded the need for better and more sustainable e-waste management and improved policies, usage and disposal methods for materials containing flame retardants.
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