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Association between...
Association between accelerometer-measured amplitude of rest-activity rhythm and future health risk : a prospective cohort study of the UK Biobank
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Feng, Hongliang (author)
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Yang, Lulu (author)
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Ai, Sizhi (author)
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Liu, Yue (author)
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Zhang, Weijie (author)
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Lei, Binbin (author)
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Chen, Jie (author)
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Liu, Yaping (author)
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Chan, Joey W Y (author)
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Chan, Ngan Yin (author)
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- Tan, Xiao (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap,Lung- allergi- och sömnforskning
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Wang, Ningjian (author)
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- Benedict, Christian, Docent, 1976- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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Jia, Fujun (author)
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Wing, Yun Kwok (author)
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Zhang, Jihui (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: The Lancet Healthy Longevity. - 2666-7568. ; 4:5, s. e200-e210
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: The health effects of rest-activity rhythm are of major interest to public health, but its associations with health outcomes remain elusive. We aimed to examine the associations between accelerometer-measured rest-activity rhythm amplitude and health risks among the general UK population.METHODS: We did a prospective cohort analysis of UK Biobank participants aged 43-79 years with valid wrist-worn accelerometer data. Low rest-activity rhythm amplitude was defined as the first quintile of relative amplitude; all other quintiles were classified as high rest-activity rhythm amplitude. Outcomes of interest were defined using International Classification of Diseases 10th Revision codes and consisted of incident cancer and cardiovascular, infectious, respiratory, and digestive diseases, and all-cause and disease-specific (cardiovascular, cancer, and respiratory) mortality. Participants with a current diagnosis of any outcome of interest were excluded. We assessed the associations between decreased rest-activity rhythm amplitude and outcomes using Cox proportional hazards models.FINDINGS: Between June 1, 2013, and Dec 23, 2015, 103 682 participants with available raw accelerometer data were enrolled. 92 614 participants (52 219 [56·4%] women and 40 395 [42·6%] men) with a median age of 64 years (IQR 56-69) were recruited. Median follow-up was 6·4 years (IQR 5·8-6·9). Decreased rest-activity rhythm amplitude was significantly associated with increased incidence of cardiovascular diseases (adjusted hazard ratio 1·11 [95% CI 1·05-1·16]), cancer (1·08 [1·01-1·16]), infectious diseases (1·31 [1·22-1·41]), respiratory diseases (1·26 [1·19-1·34]), and digestive diseases (1·08 [1·03-1·14]), as well as all-cause mortality (1·54 [1·40-1·70]) and disease-specific mortality (1·73 [1·34-2·22] for cardiovascular diseases, 1·32 [1·13-1·55] for cancer, and 1·62 [1·25-2·09] for respiratory diseases). Most of these associations were not modified by age older than 65 years or sex. Among 16 accelerometer-measured rest-activity parameters, low rest-activity rhythm amplitude had the strongest or second- strongest associations with nine health outcomes.INTERPRETATION: Our results suggest that low rest-activity rhythm amplitude might contribute to major health outcomes and provide further evidence to promote risk-modifying strategies associated with rest-activity rhythm to improve health and longevity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Feng, Hongliang
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Yang, Lulu
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Ai, Sizhi
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Liu, Yue
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Zhang, Weijie
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Lei, Binbin
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show more...
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Chen, Jie
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Liu, Yaping
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Chan, Joey W Y
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Chan, Ngan Yin
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Tan, Xiao
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Wang, Ningjian
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Benedict, Christ ...
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Jia, Fujun
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Wing, Yun Kwok
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Zhang, Jihui
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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The Lancet Healt ...
- By the university
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Uppsala University