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- Jimenez, Gretchen S., et al.
(författare)
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A transactivation-deficient mouse model provides insights into trp53 regulation and function
- 2000
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 26:1, s. 37-43
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Tidskriftsartikel (refereegranskat)abstract
- The gene Trp53 is among the most frequently mutated and studied genes in human cancer, but the mechanisms by which it suppresses tumour formation remain unclear. We generated mice with an allele encoding changes at Leu25 and Trp26, known to be essential for transcriptional transactivation and Mdm2 binding, to enable analyses of Trp53 structure and function in vivo. The mutant Trp53 was abundant, its level was not affected by DNA damage and it bound DNA constitutively; however, it showed defects in cell-cycle regulation and apoptosis. Both mutant and Trp53-null mouse embryonic fibroblasts (MEFs) were readily transformed by oncogenes, and the corresponding mice were prone to tumours. We conclude that the determining pathway for Trp53 tumour-suppressor function in mice requires the transactivation domain.
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- Sanchez-Agudo, M, et al.
(författare)
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3p -> 3d resonant photoemission spectroscopy of a TiO2 sub-monolayer grown on Al2O3
- 2004
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Ingår i: Proceedings of the 22nd European Conference on Surface Science (Surface Science). - : Elsevier BV. - 0039-6028. ; 566-68:Part 1, s. 515-519
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Konferensbidrag (refereegranskat)abstract
- The valence band resonant photoemission spectra of a TiO2 sub-monolayer grown on an Al2O3 substrate have been measured throughout the Ti 3p absorption edge, i.e. at photon energies between 40 and 60 eV. The resonance process has been analysed in terms of constant initial state (CIS) curves, showing a peak at 49.5 eV photon energy, corresponding to a Fano-like resonant process. The Ti 3d contribution to the valence band shows a significant energy shift with respect to bulk TiO2. These results are compared to cluster model calculations for a TiO6 cluster. (C) 2004 Elsevier B.V. All rights reserved.
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