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| 2. |
- O'Brien, William, et al.
(författare)
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An international review of occupant-related aspects of building energy codes and standards
- 2020
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323. ; 179
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Tidskriftsartikel (refereegranskat)abstract
- In light of recent research, it is evident that occupants are playing an increasingly important role in building energy performance. Despite the important role of building energy codes and standards in design, the occupant-related aspects are typically simple and have not kept up with the leading research. This paper reviews 23 regions’ building energy codes and standards by first comparing their quantitative aspects and then analyzing their mandated rules and approaches. While the present paper focuses on offices, general recommendations are applicable to other building types as well. The review revealed a wide range of occupant-related values, approaches, and attitudes. For example, code-specified occupant density varies by nearly a factor of three between different codes. This underlines the need for development of advancement in occupant behavior modeling approaches for future occupant-centric building performance codes and standards. Moreover, occupants are often referred to only implicitly; underlying expectations about energy-saving occupant behavior from building occupants varies greatly; and, only a few codes address occupant feedback and system usability. Based on the findings of the review, a set of initial recommendations for future building energy codes is proposed.
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| 3. |
- Abuimara, Tareq, et al.
(författare)
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Detailed Case Studies
- 2023
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Ingår i: Occupant-Centric Simulation-Aided Building Design. - 9781000865752 ; , s. 257-367
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Wireless body area networks (WBANs) are one of the key technologies that support the development of pervasive health monitoring (remote patient monitoring systems), which has attracted more attention in recent years. These WBAN applications requires stringent security requirements as they are concerned with human lives. In the recent scenario of the corona pandemic, where most of the healthcare providers are giving online services for treatment, DDoS attacks become the major threats over the internet. This chapter particularly focusses on detection of DDoS attack using machine learning algorithms over the healthcare environment. In the process of attack detection, the dataset is preprocessed. After preprocessing the dataset, the cleaned dataset is given to the popular classification algorithms in the area of machine learning namely, AdaBoost, J48, k-NN, JRip, Random Committee and Random Forest classifiers. Those algorithms are evaluated independently and the results are recorded. Results concluded that J48 outperform with accuracy of 99.98% with CICIDS dataset and random forest outperform with accuracy of 99.917, but it takes the longest model building time. Depending on the evaluation performance the appropriate classifier is selected for further DDoS detection at real-time.
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| 4. |
- Andrews, Clinton J., et al.
(författare)
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Methods to Obtain the Occupant Perspective
- 2023
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Ingår i: Occupant-Centric Simulation Aided Building Design: Theory, Application, and Case Studies. - 9781000865752 ; , s. 60-82
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter summarizes the most important methods for actively engaging occupants in the processes of designing buildings. Each stage in the building life cycle places different demands on the professional-to-occupant relationship. Both objective and subjective data are important in this relationship and raises key epistemological questions about factors that cannot be directly observed—e.g., how do we know what we know about occupant behavior? The chapter guides the reader through this intellectually dangerous terrain by suggesting that the best way to find out what people think is to ask them. Some methods discussed here are familiar to practitioners, including interviews, surveys, focus groups, and direct observation. Others are just entering widespread practice, including virtual reality simulations, ubiquitous sensors and monitoring systems, and momentary ecological assessments. Each method has strengths, weaknesses, and appropriateness for use during certain stages of the building life cycle. The key takeaways from this chapter are that (1) building designers and operators can learn much value from occupants and (2) the new skills needed to engage successfully can be quickly learned. Occupant-centric design approaches that employ these methods improve the likelihood of successful building, interface design, and occupant outcomes.
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| 5. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 6. |
- Chinazzo, Giorgia, et al.
(författare)
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Quality criteria for multi-domain studies in the indoor environment: Critical review towards research guidelines and recommendations
- 2022
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323. ; 226
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Forskningsöversikt (refereegranskat)abstract
- The perception, physiology, behavior, and performance of building occupants are influenced by multi-domain exposures: the simultaneous presence of multiple environmental stimuli, i.e., visual, thermal, acoustic, and air quality. Despite being extensive, the literature on multi-domain exposures presents heterogeneous methodological approaches and inconsistent study reporting, which hinder direct comparison between studies and meta-analyses. Therefore, in addition to carrying out more multi-domain studies, such investigations need to be designed, conducted, and documented in a systematic and transparent way. With the goal to facilitate and support future multi-domain studies and their meta-analyses, this work provides (1) a range of criteria for multi-domain study design and reporting (i.e., defined as quality criteria), and (2) a critical review of the multi-domain literature based on the described criteria, which can serve as guidelines and recommendations for future studies on the topic. The identified quality criteria encompass study set-up, study deployment and analysis, and study outcome, stressing the importance of adopting a consistent terminology and result reporting style. The developed critical review highlights several shortcomings in the design, deployment, and documentation of multi-domain studies, emphasizing the need for quality improvements of future multi-domain research. The ultimate goal of this work is to consolidate our knowledge on multi-domain exposures for its integration into regulatory resources and guidelines, which are currently dominated by single-domain knowledge.
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| 7. |
- Dispenzieri, Angela, et al.
(författare)
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Clinical and genetic profile of patients enrolled in the Transthyretin Amyloidosis Outcomes Survey (THAOS) : 14-year update
- 2022
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Ingår i: Orphanet Journal of Rare Diseases. - : BioMed Central (BMC). - 1750-1172. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Transthyretin amyloidosis (ATTR amyloidosis) is a rare, life-threatening disease caused by the accumulation of variant or wild-type (ATTRwt amyloidosis) transthyretin amyloid fibrils in the heart, peripheral nerves, and other tissues and organs.Methods: Established in 2007, the Transthyretin Amyloidosis Outcomes Survey (THAOS) is the largest ongoing, global, longitudinal observational study of patients with ATTR amyloidosis, including both inherited and wild-type disease, and asymptomatic carriers of pathogenic TTR mutations. This descriptive analysis examines baseline characteristics of symptomatic patients and asymptomatic gene carriers enrolled in THAOS since its inception in 2007 (data cutoff: August 1, 2021).Results: This analysis included 3779 symptomatic patients and 1830 asymptomatic gene carriers. Symptomatic patients were predominantly male (71.4%) and had a mean (standard deviation [SD]) age of symptom onset of 56.3 (17.8) years. Val30Met was the most common genotype in symptomatic patients in South America (80.9%), Europe (55.4%), and Asia (50.5%), and more patients had early- versus late-onset disease in these regions. The majority of symptomatic patients in North America (58.8%) had ATTRwt amyloidosis. The overall distribution of phenotypes in symptomatic patients was predominantly cardiac (40.7%), predominantly neurologic (40.1%), mixed (16.6%), and no phenotype (2.5%). In asymptomatic gene carriers, mean (SD) age at enrollment was 42.4 (15.7) years, 42.4% were male, and 73.2% carried the Val30Met mutation.Conclusions: This 14-year global overview of THAOS in over 5000 patients represents the largest analysis of ATTR amyloidosis to date and highlights the genotypic and phenotypic heterogeneity of the disease.ClinicalTrials.gov Identifier: NCT00628745.
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| 8. |
- Dong, Yi-Min, et al.
(författare)
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Development and Validation of a Nomogram for Assessing Survival in Patients With COVID-19 Pneumonia
- 2021
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press. - 1058-4838 .- 1537-6591. ; 72:4, s. 652-660
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Tidskriftsartikel (refereegranskat)abstract
- Background. The outbreak of coronavirus disease 2019 (COVID-19) has spread worldwide and continues to threaten peoples' health as well as put pressure on the accessibility of medical systems. Early prediction of survival of hospitalized patients will help in the clinical management of COVID-19, but a prediction model that is reliable and valid is still lacking. Methods. We retrospectively enrolled 628 confirmed cases of COVID-19 using positive RT-PCR tests for SARS-CoV-2 in Tongji Hospital, Wuhan, China. These patients were randomly grouped into a training (60%) and a validation (40%) cohort. In the training cohort, LASSO regression analysis and multivariate Cox regression analysis were utilized to identify prognostic factors for in-hospital survival of patients with COVID-19. A nomogram based on the 3 variables was built for clinical use. AUCs, concordance indexes (C-index), and calibration curves were used to evaluate the efficiency of the nomogram in both training and validation cohorts. Results. Hypertension, higher neutrophil-to-lymphocyte ratio, and increased NT-proBNP values were found to be significantly associated with poorer prognosis in hospitalized patients with COVID-19. The 3 predictors were further used to build a prediction nomogram. The C-indexes of the nomogram in the training and validation cohorts were 0.901 and 0.892, respectively. The AUC in the training cohort was 0.922 for 14-day and 0.919 for 21-day probability of in-hospital survival, while in the validation cohort this was 0.922 and 0.881, respectively. Moreover, the calibration curve for 14- and 21-day survival also showed high coherence between the predicted and actual probability of survival. Conclusions. We built a predictive model and constructed a nomogram for predicting in-hospital survival of patients with COVID-19. This model has good performance and might be utilized clinically in management of COVID-19.
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| 9. |
- Dong, Yi-Min, et al.
(författare)
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Reply to Collins et al
- 2021
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press. - 1058-4838 .- 1537-6591. ; 73:3, s. 558-559
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Jin, Quan, 1983, et al.
(författare)
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Improving indoor environmental quality (IEQ) for occupant health and well-being: A case study of Swedish office building
- 2020
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Ingår i: IOP Conference Series: Earth and Environmental Science. - : IOP Publishing. - 1755-1307 .- 1755-1315. ; 588:3
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Konferensbidrag (refereegranskat)abstract
- Indoor environmental quality (IEQ) is a major domain of building conditions relating to occupant comfort, health and well-being. Especially in the office environment, IEQ can influence work productivity positively. Within the 17 UN Sustainable Development Goals (SDGs), goal 3 good health and well-being, and goal 8 decent work and economic growth are the two areas where IEQ can significantly contribute. To better design sustainable office buildings in line with the agenda 2030, the study aims to examine occupant satisfaction, health and work in a newly renovated office building which is labelled by the BREEAM certification scheme Silver. Occupant preferences of IEQ comparing to the current conditions were also explored to provide advice for future design. The results show that occupant satisfaction with IEQ has not well achieved and in the office environment occupants prefer warmer temperature, more fresh air, less noise, and more daylight. We also find that perceived IEQ is extensively related to occupant health and work productivity. It concludes that in such a newly renovated office building as a high-performance building, there are still many problems from the indoor environments. Therefore, improvements are needed to gain occupant satisfaction and positively influence occupant health, well-being and work productivity.
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