| 1. |
|
|
| 2. |
- Giritli Nygren, Katarina, 1971-
(författare)
-
"e" i retorik och praktik. : Elektronisk förvaltning i översättning.
- 2009
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall purpose of this study is to contribute to the discussion of eGovernment implementation by making the implicit organisational micro dynamic processes involved in the framing and implementation of eGovernment explicit. I want to highlight the important process trough which eGovernment is framed and translated by organisational members and in what way it effects different divisions of practice. To do so, two different analytical aspects of organisational life, the rhetoric of management and the reality of work practices are used as a theoretical context for analysing some implications of eGovernment implementation. These analytical dimensions of organisational life are used to discuss a case study looking at the implementation of eGovernment in a local Swedish municipality. The main contribution of this thesis is a theorisation of how to understand the organisational micro dynamic processes involved in the implementation of eGovernment in public administration. New insights could be gained, for researchers and practioners, by analysing the transformation of practice as an ongoing process characterised by micro-political translation processes involving actors as well as actions and meanings in both rhetoric and practice.
|
|
| 3. |
|
|
| 4. |
- Johansson, Ann, et al.
(författare)
-
In vivo measurement of parameters of dosimetric importance during interstitial photodynamic therapy of thick skin tumors
- 2006
-
Ingår i: Journal of Biomedical Optics. - : SPIE-Intl Soc Optical Eng. - 1083-3668. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- A system for interstitial photodynamic therapy is used in the treatment of thick skin tumors. The system allows simultaneous measurements of light fluence rate, sensitizer fluorescence, and tissue oxygen saturation by using the same fibers as for therapeutic light delivery. Results from ten tumor treatments using delta-aminolevulinic acid (ALA)-induced protoporphyrin IX show a significant, treatment-induced increase in tissue absorption at the therapeutic wavelength, and rapid sensitizer photobleaching. The changes in oxy- and deoxyhemoglobin content are monitored by means of near-infrared spectroscopy, revealing a varying tissue oxygenation and significant changes in blood volume during treatment. These changes are consistent with the temporal profiles of the light fluence rate at the therapeutic wavelength actually measured. We therefore propose the observed absorption increase to be due to treatment-induced deoxygenation in combination with changes in blood concentration within the treated volume. A higher rate of initial photobleaching is found to correlate with a less pronounced increase in tissue absorption. Based on the measured signals, we propose how real-time treatment supervision and feedback can be implemented. Simultaneous study of the fluence rate, sensitizer fluorescence, and local tissue oxygen saturation level may contribute to the understanding of the threshold dose for photodynamic therapy. (c) 2006 Society of Photo-Optical Instrumentation Engineers.
|
|
| 5. |
- Johansson, Ann, et al.
(författare)
-
Interstitial photodynamic therapy for primary prostate cancer incorporating realtime treatment dosimetry
- 2007
-
Ingår i: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. - : SPIE. - 1042-4687 .- 1605-7422. ; 6427, s. 4270-4270
-
Konferensbidrag (refereegranskat)abstract
- Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and shortterm response to the therapeutic irradiation. Within our group, an instrument for interstitial PDT on prostate tissue that incorporates realtime treatment feedback is being developed. The treatment protocol consists of two parts. The first part incorporates the pre-treatment plan with ultrasound investigations, providing the geometry for the prostate gland and surrounding risk organs, an iterative random-search algorithm to determine near-optimal fiber positions within the reconstructed geometry and a Block-Cimmino optimization algorithm for predicting individual fiber irradiation times. During the second part, the therapeutic light delivery is combined with measurements of the light transmission signals between the optical fibers, thus monitoring the tissue effective attenuation coefficient by means of spatially resolved spectroscopy. These data are then used as input for repeated runs of the Block-Cimmino optimization algorithm. Thus, the irradiation times for individual fibers are updated throughout the treatment in order to compensate for the influence of changes in tissue composition on the light distribution at the therapeutic wavelength.
|
|
| 6. |
- Johansson, Ann, et al.
(författare)
-
System for integrated interstitial photodynamic therapy and dosimetric monitoring
- 2005
-
Ingår i: Proceedings of the SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 5689:1, s. 130-140
-
Konferensbidrag (refereegranskat)abstract
- Photodynamic therapy for the treatment of cancer relies on the presence of light, sensitizer and oxygen. By monitoring these three parameters during the treatment a better understanding and treatment control could possibly be achieved. Here we present data from in vivo treatments of solid skin tumors using an instrument for interstitial photodynamic therapy with integrated dosimetric monitoring. By using intra-tumoral ALA-administration and interstitial light delivery solid tumors are targeted. The same fibers are used for measuring the fluence rate at the treatment wavelength, the sensitizer fluorescence and the local blood oxygen saturation during the treatment. The data presented is based on 10 treatments in 8 patients with thick basal cell carcinomas. The fluence rate measurements at 635 nm indicate a major treatment induced absorption increase, leading to a limited light penetration at the treatment wavelength. This leads to a far from optimal treatment since the absorption increase prevents peripheral tumor regions from being fully treated. An interactive treatment has been implemented assisting the physician in delivering the correct light dose. The absorption increase can be compensated for by either prolonging the treatment time or increasing the output power of each individual treatment fiber. The other parameters of importance, i.e. the sensitizer fluorescence at 705 nm and the local blood oxygen saturation, are monitored in order to get an estimate of the amount of photobleaching and oxygen consumption. Based on the oxygen saturation signal, a fractionized irradiation can be introduced in order to allow for a re-oxygenation of the tissue
|
|
| 7. |
- Johansson, Katarina, et al.
(författare)
-
A Model Study on Fatty Acid Methyl Esters as Reactive Diluents in Thermally Cured Coil Coating Systems
- 2006
-
Ingår i: Progress in organic coatings. - : Elsevier BV. - 0300-9440 .- 1873-331X. ; 55:4, s. 382-387
-
Tidskriftsartikel (refereegranskat)abstract
- A model study on the transesterification reaction between fatty acid methyl ester (FAME), e.g. methyl oleate, methyl linoleate, rape seed methyl ester and different alcohols in thin films have been performed. The purpose was to evaluate the possibility to use fatty acid methyl ester (FAME) as reactive diluent in thermally cured coil-coating paints. A reactive diluent must be compatible, act as a diluent, react into the film without affecting the end properties. The transesterification between the methyl ester and hydroxyl functional model compounds was monitored by 1H-NMR and real time IR. The effects addressed in the present study were compatibility, temperature, catalyst, alcohol structure, and fatty acid methyl ester (FAME) structure. Competing factors with the transesterification reaction were shown to be evaporation and side reactions i.e. oxidation. The structure of the fatty acid methyl ester (FAME) affects the conversion as a higher amount of unsaturations triggers the competing side reaction oxidation. The reaction time and temperature affects both the degree of transesterification conversion, degree of side reactions and the catalyst choice. The present study has shown that a fatty acid methyl ester (FAME) fulfils the reactivity part for a reactive diluent in a thermally cured coating system.
|
|
| 8. |
- Johansson, Katarina, et al.
(författare)
-
Fatty Acid Methyl Ester as Reactive Diluent in Thermally Cured Solvent-Borne Coil-Coatings : The Effect of Fatty Acid Pattern on the Curing Performance and Final Properties
- 2008
-
Ingår i: Progress in organic coatings. - : Elsevier BV. - 0300-9440 .- 1873-331X. ; 63:2, s. 155-159
-
Tidskriftsartikel (refereegranskat)abstract
- Four different fatty acid methyl esters (FAMEs): rape seedmethyl ester (RME), tall oil methyl ester (TOME), and two types of linseed oilmethyl ester (Linutin) have been studied as reactive diluents in thermally cured solvent-borne coil-coatings. The purpose was to evaluate the effect of fatty acid methyl ester structure on the curing performance and final properties of the coating. The permanent incorporation of the reactive diluent via transesterification reaction has been followed with 1H NMR analysis of model systems. Dynamic mechanical analysis (DMA) measurements, of free-standing films, showthat the glass transition temperature (Tg) decreases upon addition of the reactive diluent. Both the amount of incorporated reactive diluent and the final film properties are affected by the number and placement of alkene-bonds in the FAME.
|
|
| 9. |
|
|
| 10. |
- Johansson, Katarina, 1980-
(författare)
-
Fatty acid methyl esters as reactive diluents in solvent-borne thermally cured coil-coatings
- 2006
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This work describes how a fatty acid methyl ester (FAME) derived from a vegetable oil can be introduced as reactive diluent in a solvent-borne thermally cured coil-coating system. The evaluated reactive diluent, rape seed methyl ester (RME), has been evaluated both in a fully formulated clear coat system and via model studies. A reactive diluent is a compound that acts as a solvent in the liquid paint, lowering the viscosity, and chemically reacts into the final film during cure. Introduction of a reactive diluent derived from vegetable oil give a more environmental compliant coating since a renewable material is incorporated in the coating and the amount of traditional solvent can be decreased. These positive environmental factors have increased the industrial interest. The fully formulated clear coat studies describes how addition of reactive diluent affects rheological properties of the wet paint, film formation, incorporation, and final film properties in a hydroxyl-functional polyester/melamine coil-coating system. The coating were cured under industrial coil-coating cure conditions and analyzed with Raman, carbon-14 dating, extraction, dynamic mechanical analysis, and visually observed. Viscosity measurement of the wet paint show that RME works as a diluent. RME increase the mobility in the system enhancing the film formation process and occurrence of defect-free films. The incorporation of RME could not be confirmed by Raman analysis. However, carbon-14 dating did indicate the presence of RME that could not be extracted from the films. The appearance and mechanical properties of the films were also significantly affected by addition of RME. Dynamic mechanical analysis of the free standing films showed that the final film properties were affected by oven temperature, choice of co-solvent, and flash-off period. Model studies were performed to further clarify how RME chemically can react through transesterification with the hydroxyl-groups of the polyester. RME and its two main components methyl oleate and methyl linoleate were reacted with primary alcohols with and without tertiary hydrogen both under low temperature (110, 130, 150, 170°C) and industrial cure conditions. The transesterification reaction was monitored with 1H-NMR and real time IR. Evaporation and side reactions, e.g. oxidation, are competing factors with the transesterification reaction. The fatty acid structure affects the conversion as a higher amount of unsaturations triggers higher degree of oxidation. The study also showed that reaction time and temperature affects the transesterification conversion, degree of side reactions, and catalyst choice.
|
|
